Microspheres as a Carrier System for Therapeutic Embolization Procedures: Achievements and Advances.
TACE
TAE
TARE
embolization
hepatocellular carcinoma
microspheres
therapy
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
24 Jan 2023
24 Jan 2023
Historique:
received:
30
12
2022
revised:
17
01
2023
accepted:
20
01
2023
entrez:
11
2
2023
pubmed:
12
2
2023
medline:
12
2
2023
Statut:
epublish
Résumé
The targeted delivery of anti-cancer drugs and isotopes is one of the most pursued goals in anti-cancer therapy. One of the prime examples of such an application is the intra-arterial injection of microspheres containing cytostatic drugs or radioisotopes during hepatic embolization procedures. Therapy based on the application of microspheres revolves around vascular occlusion, complemented with local therapy in the form of trans-arterial chemoembolization (TACE) or radioembolization (TARE). The broadest implementation of these embolization strategies currently lies within the treatment of untreatable hepatocellular cancer (HCC) and metastatic colorectal cancer. This review aims to describe the state-of-the-art TACE and TARE technologies investigated in the clinical setting for HCC and addresses current trials and new developments. In addition, chemical properties and advancements in microsphere carrier systems are evaluated, and possible improvements in embolization therapy based on the modification of and functionalization with therapeutical loads are explored.
Identifiants
pubmed: 36769566
pii: jcm12030918
doi: 10.3390/jcm12030918
pmc: PMC9917963
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Netherlands Organisation for Applied Scientific Research
ID : TTW 16141
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