Physical Properties and Antimicrobial Release Ability of Gentamicin-Loaded Apatite Cement/α-TCP Composites: An In Vitro Study.
alpha-tricalcium phosphate
apatite cement
gentamicin
hydroxyapatite
Journal
Materials (Basel, Switzerland)
ISSN: 1996-1944
Titre abrégé: Materials (Basel)
Pays: Switzerland
ID NLM: 101555929
Informations de publication
Date de publication:
21 Jan 2023
21 Jan 2023
Historique:
received:
06
01
2023
revised:
18
01
2023
accepted:
18
01
2023
entrez:
11
2
2023
pubmed:
12
2
2023
medline:
12
2
2023
Statut:
epublish
Résumé
Apatite cement (AC), which has excellent osteoconductive ability, and alpha-tricalcium phosphate (α-TCP), which can be used for bone replacement, are useful bone substitute materials. The objective of this study was to clarify the physical properties and antimicrobial release ability of antibiotic-loaded AC/α-TCP composites in vitro. Gentamicin-loaded, rapid setting AC/α-TCP composites were prepared in 2 mixing ratios (10:3 and 10:6). The cement paste of AC/α-TCP composites was prepared in a plastic mold and dried in a thermostatic chamber at 37 °C and 100% relative humidity for 24 h. A diametral tensile strength test, powder X-ray diffraction analysis, and gentamicin release test were performed. The diametral tensile strengths of the AC/α-TCP composites were significantly less than that of AC alone. Powder X-ray diffraction patterns exhibited the characteristic peaks of hydroxyapatite in the AC/α-TCP composites and gentamicin-loaded AC/α-TCP composites. The concentration of the released gentamicin was maintained above the minimum inhibitory concentration of
Identifiants
pubmed: 36770002
pii: ma16030995
doi: 10.3390/ma16030995
pmc: PMC9918266
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Hiroshima University grant funding
ID : Hiroshima University, no. 0G2130
Références
Bioinorg Chem Appl. 2021 Nov 30;2021:2058149
pubmed: 34887909
Dent Mater J. 2022 Nov 30;41(6):882-888
pubmed: 36002294
Acta Biomater. 2022 Oct 1;151:70-87
pubmed: 36028195
Int J Nanomedicine. 2017 Feb 14;12:1227-1249
pubmed: 28243086
Materials (Basel). 2018 Oct 16;11(10):
pubmed: 30332751
J Formos Med Assoc. 2014 Feb;113(2):72-82
pubmed: 24216440
Materials (Basel). 2020 Mar 01;13(5):
pubmed: 32121595
Dent Mater J. 2007 May;26(3):342-7
pubmed: 17694742
Materials (Basel). 2016 Apr 13;9(4):
pubmed: 28773408
Arch Otolaryngol Head Neck Surg. 1991 Apr;117(4):379-84
pubmed: 1848766
Biomaterials. 1995 Jul;16(11):855-60
pubmed: 8527601
Polymers (Basel). 2021 Jul 08;13(14):
pubmed: 34300997
Arch Otolaryngol Head Neck Surg. 1991 Apr;117(4):385-9
pubmed: 1848767
Front Biosci. 2007 Jan 01;12:1450-62
pubmed: 17127393
Dent Mater J. 1992 Jun;11(1):11-6
pubmed: 1327659
J Antimicrob Chemother. 2022 Apr 27;77(5):1218-1227
pubmed: 35211738
Cureus. 2022 Oct 26;14(10):e30713
pubmed: 36439590
Arch Otolaryngol Head Neck Surg. 1993 Feb;119(2):185-90
pubmed: 8427682
Plast Reconstr Surg. 1992 Aug;90(2):174-85; discussion 186-91
pubmed: 1321453
J Bone Joint Surg Br. 1992 Jul;74(4):600-4
pubmed: 1320622
Biomaterials. 2004 Mar-Apr;25(7-8):1159-66
pubmed: 14643589
Dent Mater J. 1995 Jun;14(1):45-57
pubmed: 8940545
Biomed Res Int. 2015;2015:579541
pubmed: 26504813
J Bone Jt Infect. 2022 Jul 25;7(4):163-167
pubmed: 36032800
Antibiotics (Basel). 2022 Feb 28;11(3):
pubmed: 35326785