Design and Synthesis of New Modified Flexible Purine Bases as Potential Inhibitors of Human PNP.

Humans Purine-Nucleoside Phosphorylase / chemistry Escherichia coli / metabolism Purines / pharmacology Nucleosides / chemistry Enzyme Inhibitors / pharmacology
aza/deazapurines fleximer inhibitor human purine nucleoside phosphorylase

Journal

Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009

Informations de publication

Date de publication:
17 Jan 2023
Historique:
received: 25 12 2022
revised: 09 01 2023
accepted: 11 01 2023
entrez: 11 2 2023
pubmed: 12 2 2023
medline: 15 2 2023
Statut: epublish

Résumé

The great interest in studying the structure of human purine nucleoside phosphorylase (

Identifiants

DOI: 10.3390/molecules28030928 PMID: 36770593 PMC: PMC9921493
pubmed: 36770593
pii: molecules28030928
doi: 10.3390/molecules28030928
pmc: PMC9921493
pii:
doi:

Substances chimiques

Purine-Nucleoside Phosphorylase EC 2.4.2.1
Purines 0
Nucleosides 0
Enzyme Inhibitors 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Russian Science Foundation
ID : 19-74-10048 (design and chemical synthesis) and 21-13-00429 (enzymatic studies)

Références

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Auteurs

Anastasia Khandazhinskaya (A)

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
ORCID: 0000-0003-1452-0253

Ilja Fateev (I)

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
ORCID: 0000-0002-8571-4197

Barbara Eletskaya (B)

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
ORCID: 0000-0002-9552-7141

Anna Maslova (A)

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.

Irina Konstantinova (I)

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.

Katherine Seley-Radtke (K)

Department of Chemistry & Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250, USA.
ORCID: 0000-0002-0154-3459

Sergey Kochetkov (S)

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
ORCID: 0000-0002-7443-6961

Elena Matyugina (E)

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
ORCID: 0000-0002-4981-7316

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Design and Synthesis of New Modified Flexible...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Glycosyltransferase › Pentosyltransferases › Purine nucleoside phosphorylase › Design and Synthesis of New Modified Flexible...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › Design and Synthesis of New Modified Flexible...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Purines › Design and Synthesis of New Modified Flexible...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Design and Synthesis of New Modified Flexible...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Design and Synthesis of New Modified Flexible...