Approved Small-Molecule ATP-Competitive Kinases Drugs Containing Indole/Azaindole/Oxindole Scaffolds: R&D and Binding Patterns Profiling.
approved ATP-competitive kinases drugs
cancer
drug design
drug discovery
indole/azaindole/oxindole derivatives
kinases binding patterns
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
17 Jan 2023
17 Jan 2023
Historique:
received:
01
12
2022
revised:
02
01
2023
accepted:
05
01
2023
entrez:
11
2
2023
pubmed:
12
2
2023
medline:
15
2
2023
Statut:
epublish
Résumé
Kinases are among the most important families of biomolecules and play an essential role in the regulation of cell proliferation, apoptosis, metabolism, and other critical physiological processes. The dysregulation and gene mutation of kinases are linked to the occurrence and development of various human diseases, especially cancer. As a result, a growing number of small-molecule drugs based on kinase targets are being successfully developed and approved for the treatment of many diseases. The indole/azaindole/oxindole moieties are important key pharmacophores of many bioactive compounds and are generally used as excellent scaffolds for drug discovery in medicinal chemistry. To date, 30 ATP-competitive kinase inhibitors bearing the indole/azaindole/oxindole scaffold have been approved for the treatment of diseases. Herein, we summarize their research and development (R&D) process and describe their binding models to the ATP-binding sites of the target kinases. Moreover, we discuss the significant role of the indole/azaindole/oxindole skeletons in the interaction of their parent drug and target kinases, providing new medicinal chemistry inspiration and ideas for the subsequent development and optimization of kinase inhibitors.
Identifiants
pubmed: 36770611
pii: molecules28030943
doi: 10.3390/molecules28030943
pmc: PMC9920796
pii:
doi:
Substances chimiques
Oxindoles
0
Protein Kinase Inhibitors
0
Adenosine Triphosphate
8L70Q75FXE
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Natural Science Foundation of Fujian Province of China
ID : 2022Y0001
Organisme : Special fund for marine development of Fujian province
ID : FJHJF-L-2021-5
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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