Future Antimicrobials: Natural and Functionalized Phenolics.
alkylation
esterification
flavonoids
lignans
minimal inhibitory concentration
tannins
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
22 Jan 2023
22 Jan 2023
Historique:
received:
07
12
2022
revised:
13
01
2023
accepted:
20
01
2023
entrez:
11
2
2023
pubmed:
12
2
2023
medline:
15
2
2023
Statut:
epublish
Résumé
With incidence of antimicrobial resistance rising globally, there is a continuous need for development of new antimicrobial molecules. Phenolic compounds having a versatile scaffold that allows for a broad range of chemical additions; they also exhibit potent antimicrobial activities which can be enhanced significantly through functionalization. Synthetic routes such as esterification, phosphorylation, hydroxylation or enzymatic conjugation may increase the antimicrobial activity of compounds and reduce minimal concentrations needed. With potent action mechanisms interfering with bacterial cell wall synthesis, DNA replication or enzyme production, phenolics can target multiple sites in bacteria, leading to a much higher sensitivity of cells towards these natural compounds. The current review summarizes some of the most important knowledge on functionalization of natural phenolic compounds and the effects on their antimicrobial activity.
Identifiants
pubmed: 36770780
pii: molecules28031114
doi: 10.3390/molecules28031114
pmc: PMC9920704
pii:
doi:
Substances chimiques
Anti-Infective Agents
0
Phenols
0
Plant Extracts
0
Antioxidants
0
Anti-Bacterial Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Research, Innovation and Digitization, CCCDI-UEFISCDI
ID : PN-III-P2-2.1-PED-2021-4380
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