Cation-Chloride Cotransporters KCC2 and NKCC1 as Therapeutic Targets in Neurological and Neuropsychiatric Disorders.
Alzheimer’s disease
Down syndrome
GABA
Huntington’s disease
KCC2
NKCC1
Parkinson’s disease
epilepsy
neurodevelopment
neuropsychiatric
schizophrenia
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
31 Jan 2023
31 Jan 2023
Historique:
received:
25
11
2022
revised:
21
01
2023
accepted:
25
01
2023
entrez:
11
2
2023
pubmed:
12
2
2023
medline:
15
2
2023
Statut:
epublish
Résumé
Neurological diseases including Alzheimer's, Huntington's disease, Parkinson's disease, Down syndrome and epilepsy, and neuropsychiatric disorders such as schizophrenia, are conditions that affect not only individuals but societies on a global scale. Current therapies offer a means for small symptomatic relief, but recently there has been increasing demand for therapeutic alternatives. The γ-aminobutyric acid (GABA)ergic signaling system has been investigated for developing new therapies as it has been noted that any dysfunction or changes to this system can contribute to disease progression. Expression of the K-Cl-2 (KCC2) and N-K-C1-1 (NKCC1) cation-chloride cotransporters (CCCs) has recently been linked to the disruption of GABAergic activity by affecting the polarity of GABA
Identifiants
pubmed: 36771011
pii: molecules28031344
doi: 10.3390/molecules28031344
pmc: PMC9920462
pii:
doi:
Substances chimiques
Cations
0
Chlorides
0
Solute Carrier Family 12, Member 2
0
Symporters
0
SLC12A5 protein, human
0
SLC12A2 protein, human
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
J Neurochem. 1991 Feb;56(2):720-3
pubmed: 1988566
Trends Neurosci. 2003 Apr;26(4):199-206
pubmed: 12689771
Proc Natl Acad Sci U S A. 2006 May 30;103(22):8465-8
pubmed: 16709666
Neurosci Biobehav Rev. 2018 Jul;90:260-271
pubmed: 29729285
Pharmacol Rev. 1998 Jun;50(2):291-313
pubmed: 9647870
Trends Pharmacol Sci. 2021 Jul;42(7):605-616
pubmed: 33992468
Neuron. 2009 Mar 26;61(6):820-38
pubmed: 19323993
Neuropsychopharmacology. 2015 Jan;40(1):190-206
pubmed: 24759129
Arch Gen Psychiatry. 2011 Jan;68(1):21-31
pubmed: 20819979
Arch Dis Child Fetal Neonatal Ed. 2007 Mar;92(2):F148-50
pubmed: 17337664
Clin Psychopharmacol Neurosci. 2020 May 31;18(2):174-187
pubmed: 32329299
Physiology (Bethesda). 2009 Aug;24:257-65
pubmed: 19675357
Ann Neurol. 1985 Mar;17(3):278-82
pubmed: 3158266
Trends Neurosci. 2007 Jul;30(7):317-24
pubmed: 17499860
Ann N Y Acad Sci. 2015 Mar;1338:38-57
pubmed: 25315318
Proc Natl Acad Sci U S A. 2010 Jan 19;107(3):1211-6
pubmed: 20080551
Clin Neuropharmacol. 2016 Jan-Feb;39(1):57-9
pubmed: 26757306
Front Neurosci. 2019 Apr 24;13:310
pubmed: 31068771
Acta Neuropathol. 1991;82(4):239-59
pubmed: 1759558
Front Mol Neurosci. 2019 Oct 25;12:258
pubmed: 31708741
Arch Neurol. 2009 Apr;66(4):435-40
pubmed: 19204149
Transl Psychiatry. 2012 Dec 11;2:e202
pubmed: 23233021
J Biol Chem. 2003 Apr 4;278(14):11811-7
pubmed: 12556450
J Neurosci. 2009 Mar 18;29(11):3419-30
pubmed: 19295148
Nat Commun. 2020 Jan 7;11(1):78
pubmed: 31911626
J Neurosci. 2010 Oct 13;30(41):13707-17
pubmed: 20943911
Cell Stem Cell. 2009 Dec 4;5(6):634-45
pubmed: 19951691
Neurochem Int. 2023 Jan;162:105441
pubmed: 36375633
Chem. 2020 Aug 06;6(8):2073-2096
pubmed: 32818158
Nat Med. 2005 Nov;11(11):1205-13
pubmed: 16227993
Transl Psychiatry. 2020 Jan 27;10(1):9
pubmed: 32066666
Neuron. 2015 Aug 19;87(4):699-715
pubmed: 26291156
Acta Paediatr. 2010 Dec;99(12):1885-8
pubmed: 20608900
Trends Neurosci. 2017 Sep;40(9):536-554
pubmed: 28818303
Front Hum Neurosci. 2017 Jul 11;11:354
pubmed: 28744208
Physiol Rev. 2005 Apr;85(2):423-93
pubmed: 15788703
Science. 2008 Sep 19;321(5896):1686-9
pubmed: 18802001
Nat Neurosci. 2016 Sep;19(9):1197-200
pubmed: 27500406
J Neurophysiol. 1989 Nov;62(5):1018-27
pubmed: 2573696
J Neurochem. 2018 Sep;146(6):649-669
pubmed: 29645219
Trends Pharmacol Sci. 2021 Dec;42(12):1009-1034
pubmed: 34620512
Mol Ther. 2021 Oct 6;29(10):3072-3092
pubmed: 34058387
Schizophr Res. 2017 Jun;184:145-146
pubmed: 27956008
Neurol Clin Pract. 2011 Dec;1(1):14-23
pubmed: 23634355
Aust N Z J Psychiatry. 2007 Apr;41(4):308-20
pubmed: 17464717
Cell. 2018 Sep 6;174(6):1599
pubmed: 30193115
J Biomed Sci. 2015 Jun 11;22:41
pubmed: 26062604
J Neurosci. 2000 Feb 15;20(4):1414-23
pubmed: 10662832
J Neurosci. 2012 Apr 11;32(15):5216-22
pubmed: 22496567
Science. 2014 Feb 7;343(6171):675-9
pubmed: 24503856
Front Mol Neurosci. 2022 Oct 17;15:954167
pubmed: 36324524
Neuroscience. 2017 May 20;351:108-118
pubmed: 28385633
Arch Biochem Biophys. 2002 May 15;401(2):187-97
pubmed: 12054469
Am J Physiol. 1997 Nov;273(5):C1516-25
pubmed: 9374636
J Neurosci. 2012 Dec 12;32(50):18047-53
pubmed: 23238720
Neurochem Int. 1999 May;34(5):387-90
pubmed: 10397366
Int J Mol Sci. 2017 Aug 21;18(8):
pubmed: 28825683
Neural Regen Res. 2018 Aug;13(8):1362-1363
pubmed: 30106045
Neuroscience. 2001;104(4):933-46
pubmed: 11457581
Neuron. 1991 Jul;7(1):91-100
pubmed: 2069816
Neurosci Biobehav Rev. 2016 Sep;68:547-562
pubmed: 27328788
Nat Rev Neurosci. 2014 Oct;15(10):637-54
pubmed: 25234263
Eur J Neurosci. 2002 Jan;15(2):233-45
pubmed: 11849291
Nat Med. 2013 Nov;19(11):1524-8
pubmed: 24097188
Cell. 2007 Sep 21;130(6):1146-58
pubmed: 17825401
Ann Neurol. 1986 Nov;20(5):616-21
pubmed: 2878639
Nat Rev Neurosci. 2002 Sep;3(9):728-39
pubmed: 12209121
Front Neurol. 2020 Jan 17;10:1407
pubmed: 32010056
Front Cell Neurosci. 2022 Jan 14;15:817013
pubmed: 35095429
Nat Neurosci. 2010 Jul;13(7):812-8
pubmed: 20581818
J Psychiatr Res. 2016 Jun;77:22-6
pubmed: 26955005
Dev Dyn. 2018 Jan;247(1):94-110
pubmed: 28850760
Trends Neurosci. 2013 Dec;36(12):726-737
pubmed: 24139641
Nature. 1971 Feb 26;229(5287):628-30
pubmed: 4925465
Front Physiol. 2022 Dec 15;13:1045520
pubmed: 36589461
J Neurosci. 2009 Jun 17;29(24):7776-87
pubmed: 19535589
Neuron. 2003 Mar 27;37(6):925-37
pubmed: 12670422
J Clin Invest. 2013 Jul;123(7):2961-4
pubmed: 23921125
Nat Rev Dis Primers. 2015 Nov 12;1:15067
pubmed: 27189524
J Physiol. 1988 Dec;406:443-68
pubmed: 2855437
Transl Psychiatry. 2017 May 9;7(5):e1124
pubmed: 28485727
Neuropharmacology. 2007 Sep;53(4):524-33
pubmed: 17681355
Clin Neuropharmacol. 2016 Mar-Apr;39(2):115-7
pubmed: 26966887
J Neurosci. 2011 Jul 27;31(30):11088-95
pubmed: 21795557
Bioinformatics. 2016 May 1;32(9):1436-8
pubmed: 26748106
Cereb Cortex. 2011 Mar;21(3):574-87
pubmed: 20624842
Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1618-E1626
pubmed: 29382760
Cell Rep. 2016 Apr 5;15(1):96-103
pubmed: 27052180
Proc Natl Acad Sci U S A. 2012 May 29;109(22):8740-5
pubmed: 22592800
J Psychopharmacol. 2011 Aug;25(8):1030-42
pubmed: 21693554
Am J Physiol. 1995 Mar;268(3 Pt 1):C747-54
pubmed: 7900779
Muscle Nerve. 2001 May;24(5):581-601
pubmed: 11317268
Eur J Pharmacol. 2022 Feb 15;917:174771
pubmed: 35041847
Neuropharmacology. 2004 Aug;47(2):253-62
pubmed: 15223304
Front Pediatr. 2014 Jul 08;2:70
pubmed: 25072038
J Biol Chem. 2006 Jan 13;281(2):1016-26
pubmed: 16291749
J Anat. 1959 Oct;93:420-33
pubmed: 13829103
Nat Aging. 2021 Oct;1(10):932-947
pubmed: 36172600
Nat Clin Pract Neurol. 2008 Sep;4(9):490-503
pubmed: 18769373
Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):6726-30
pubmed: 1323116
Epilepsy Res. 2008 May;79(2-3):201-12
pubmed: 18394864
Nature. 2010 Nov 11;468(7321):263-9
pubmed: 21068835
J Biol Chem. 1999 Sep 17;274(38):26946-55
pubmed: 10480906
Nature. 1999 Jan 21;397(6716):251-5
pubmed: 9930699
Neurosci Biobehav Rev. 2014 Oct;46 Pt 2:218-27
pubmed: 24412222
Molecules. 2022 Apr 10;27(8):
pubmed: 35458638
Epilepsy Res. 2007 May;74(2-3):220-7
pubmed: 17344024
Nat Neurosci. 2011 Jun;14(6):736-43
pubmed: 21532577
Autism. 2015 Feb;19(2):149-57
pubmed: 24343334
Cell. 2012 Mar 2;148(5):1051-64
pubmed: 22385968
Neuropharmacology. 2013 Jun;69:62-74
pubmed: 22705273
Brain Res. 2003 Jan 24;961(1):22-31
pubmed: 12535773
Nat Rev Neurosci. 2005 Apr;6(4):312-24
pubmed: 15803162
Nat Commun. 2018 Apr 12;9(1):1422
pubmed: 29651049
J Biol Chem. 2010 May 7;285(19):14115-21
pubmed: 20223824
Neuroscience. 2000;98(4):669-75
pubmed: 10891610
Neurobiol Aging. 2006 Nov;27(11):1658-72
pubmed: 16271420
Sci Signal. 2014 Jul 15;7(334):re3
pubmed: 25028718
Eur J Neurosci. 2004 Feb;19(3):590-600
pubmed: 14984409
Dev Neurosci. 2011;33(5):349-64
pubmed: 21934270
J Neurochem. 2018 Jun;145(5):374-392
pubmed: 29485232
Sci Signal. 2021 Nov 09;14(708):eabg2648
pubmed: 34752143
Acta Neurobiol Exp (Wars). 2014;74(3):276-87
pubmed: 25231847
Biochem Biophys Res Commun. 2005 Dec 30;338(4):1913-9
pubmed: 16289381
Eur J Neurosci. 2010 Mar;31(6):1100-7
pubmed: 20214679
Trends Pharmacol Sci. 2020 Dec;41(12):897-899
pubmed: 33097285
Eur J Neurosci. 2003 Dec;18(12):3199-206
pubmed: 14686894
J Neurosci. 2007 Sep 12;27(37):9866-73
pubmed: 17855601
Am J Physiol. 1997 Jan;272(1 Pt 1):C173-83
pubmed: 9038823
Brain Res Mol Brain Res. 2002 Jun 30;103(1-2):91-105
pubmed: 12106695
Nat Med. 2015 Apr;21(4):318-26
pubmed: 25774849
Nature. 2009 Jun 4;459(7247):698-702
pubmed: 19396159
Epilepsia. 2018 Jan;59(1):37-66
pubmed: 29247482
J Neurosci. 2010 Jul 21;30(29):9929-38
pubmed: 20660275
Funct Neurol. 1987 Jul-Sep;2(3):355-61
pubmed: 2826308
J Neurosci. 1999 Jun 15;19(12):4695-704
pubmed: 10366603
PLoS One. 2013 Jul 19;8(7):e68851
pubmed: 23894354
Cells. 2020 Jan 17;9(1):
pubmed: 31963584
Nat Rev Genet. 2015 Jul;16(7):421-33
pubmed: 26077373