Sulforaphane Treatment in Children with Autism: A Prospective Randomized Double-Blind Study.
autism
children
sulforaphane
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
31 Jan 2023
31 Jan 2023
Historique:
received:
07
01
2023
revised:
24
01
2023
accepted:
28
01
2023
entrez:
11
2
2023
pubmed:
12
2
2023
medline:
15
2
2023
Statut:
epublish
Résumé
Autism spectrum disorder (ASD) is a pervasive neurodevelopmental disorder with repetitive behaviour which affects interaction and communication. Sulforaphane (SFN), an isothiocyanate abundant in the seeds and sprouts of cruciferous vegetables, has been shown to be effective in alleviating autistic behaviour. We performed a prospective double-blind placebo-controlled study to examine the possible effect of SFN in a paediatric cohort aged three to seven years based on measurements of the Autism Diagnostic Observation Schedule-2 (ADOS-2), the Social Responsiveness Scale-2 (SRS-2), and the Aberrant Behaviour Checklist (ABC). The study consisted of three visits over the duration of 36 weeks (baseline, 18 weeks, and 36 weeks). Twenty-eight of the 40 randomized children completed the study. The mean total raw scores on ABC and SRS-2 improved in both groups, but none of the changes reached statistical significance (ABC: 0 weeks
Identifiants
pubmed: 36771424
pii: nu15030718
doi: 10.3390/nu15030718
pmc: PMC9920098
pii:
doi:
Substances chimiques
sulforaphane
GA49J4310U
Isothiocyanates
0
Types de publication
Randomized Controlled Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of the Agriculture of the Czech Republic
ID : QK1910264
Organisme : Ministry of the Health of the Czech Republic
ID : RVO-VFN-64165/2012
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