TXNIP overexpression in mice enhances streptozotocin-induced diabetes severity.
Apoptosis
Blood glucose
Diabetes mellitus
Diet-induced obesity
Mouse model
TXNIP
Journal
Molecular and cellular endocrinology
ISSN: 1872-8057
Titre abrégé: Mol Cell Endocrinol
Pays: Ireland
ID NLM: 7500844
Informations de publication
Date de publication:
05 04 2023
05 04 2023
Historique:
received:
28
11
2022
revised:
18
01
2023
accepted:
09
02
2023
pubmed:
12
2
2023
medline:
8
3
2023
entrez:
11
2
2023
Statut:
ppublish
Résumé
Thioredoxin-interacting protein (TXNIP) is a key player in the endocrine pancreas; it induces beta cell apoptosis, such that TXNIP deficiency promotes beta cell survival. To study its function in more detail, we generated transgenic mice with ubiquitous overexpression of TXNIP. CBA
Identifiants
pubmed: 36773839
pii: S0303-7207(23)00036-9
doi: 10.1016/j.mce.2023.111885
pii:
doi:
Substances chimiques
Blood Glucose
0
Streptozocin
5W494URQ81
Glucose
IY9XDZ35W2
Thioredoxins
52500-60-4
Txnip protein, mouse
0
Carrier Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
111885Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no conflict of interest.