Future of Lung Transplantation: Xenotransplantation and Bioengineering Lungs.

Animals Humans Swine Transplantation, Heterologous Lung Transplantation Lung / surgery Bioengineering Tissue and Organ Procurement
Bioengineering Ex vivo lung perfusion Lung transplant Tissue engineering Xenotransplantation

Journal

Clinics in chest medicine
ISSN: 1557-8216
Titre abrégé: Clin Chest Med
Pays: United States
ID NLM: 7907612

Informations de publication

Date de publication:
03 2023
Historique:
entrez: 11 2 2023
pubmed: 12 2 2023
medline: 15 2 2023
Statut: ppublish

Résumé

Xenotransplantation promises to alleviate the issue of donor organ shortages and to decrease waiting times for transplantation. Recent advances in genetic engineering have allowed for the creation of pigs with up to 16 genetic modifications. Several combinations of genetic modifications have been associated with extended graft survival and life-supporting function in experimental heart and kidney xenotransplants. Lung xenotransplantation carries specific challenges related to the large surface area of the lung vascular bed, its innate immune system's intrinsic hyperreactivity to perceived 'danger', and its anatomic vulnerability to airway flooding after even localized loss of alveolocapillary barrier function. This article discusses the current status of lung xenotransplantation, and challenges related to immunology, physiology, anatomy, and infection. Tissue engineering as a feasible alternative to develop a viable lung replacement solution is discussed.

Identifiants

DOI: 10.1016/j.ccm.2022.11.003 PMID: 36774165
pubmed: 36774165
pii: S0272-5231(22)00119-8
doi: 10.1016/j.ccm.2022.11.003
pii:
doi:

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

201-214

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Auteurs

Justin C Y Chan (JCY)

NYU Transplant Institute, New York University, 530 1st Avenue, Suite 7R, New York, NY 10016, USA. Electronic address: justin.chan2@nyulangone.org.

Ryan Chaban (R)

Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA; Department of Cardiovascular Surgery, University Hospital of Johannes Gutenberg University, Langenbeckstr. 1, Bau 505, 5. OG55131 Mainz, Germany.

Stephanie H Chang (SH)

NYU Transplant Institute, New York University, 530 1st Avenue, Suite 7R, New York, NY 10016, USA.

Luis F Angel (LF)

NYU Transplant Institute, New York University, 530 1st Avenue, Suite 7R, New York, NY 10016, USA.

Robert A Montgomery (RA)

NYU Transplant Institute, New York University, 530 1st Avenue, Suite 7R, New York, NY 10016, USA.

Richard N Pierson (RN)

Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Future of Lung Transplantation:...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Future of Lung Transplantation:...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Suidae › Future of Lung Transplantation:...
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation hétérologue › Future of Lung Transplantation:...
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation d'organe › Transplantation pulmonaire › Future of Lung Transplantation:...
questionsmedicales.fr › Appareil respiratoire › Poumon › Future of Lung Transplantation:...
questionsmedicales.fr › Technologie, industrie et agriculture › Ingénierie › Bioingénierie › Future of Lung Transplantation:...
questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Services de santé › Acquisition d'organes et de tissus › Future of Lung Transplantation:...