Current challenges and future directions for engineering extracellular vesicles for heart, lung, blood and sleep diseases.

United States Extracellular Vesicles / metabolism Cell Communication Nucleic Acids / metabolism Lung / metabolism Sleep
Heart, lung, blood and sleep (HLBS) diseases extracellular vesicles (EVs) therapeutics and diagnostics

Journal

Journal of extracellular vesicles
ISSN: 2001-3078
Titre abrégé: J Extracell Vesicles
Pays: United States
ID NLM: 101610479

Informations de publication

Date de publication:
02 2023
Historique:
revised: 19 12 2022
received: 12 09 2022
accepted: 09 01 2022
entrez: 13 2 2023
pubmed: 14 2 2023
medline: 15 2 2023
Statut: ppublish

Résumé

Extracellular vesicles (EVs) carry diverse bioactive components including nucleic acids, proteins, lipids and metabolites that play versatile roles in intercellular and interorgan communication. The capability to modulate their stability, tissue-specific targeting and cargo render EVs as promising nanotherapeutics for treating heart, lung, blood and sleep (HLBS) diseases. However, current limitations in large-scale manufacturing of therapeutic-grade EVs, and knowledge gaps in EV biogenesis and heterogeneity pose significant challenges in their clinical application as diagnostics or therapeutics for HLBS diseases. To address these challenges, a strategic workshop with multidisciplinary experts in EV biology and U.S. Food and Drug Administration (USFDA) officials was convened by the National Heart, Lung and Blood Institute. The presentations and discussions were focused on summarizing the current state of science and technology for engineering therapeutic EVs for HLBS diseases, identifying critical knowledge gaps and regulatory challenges and suggesting potential solutions to promulgate translation of therapeutic EVs to the clinic. Benchmarks to meet the critical quality attributes set by the USFDA for other cell-based therapeutics were discussed. Development of novel strategies and approaches for scaling-up EV production and the quality control/quality analysis (QC/QA) of EV-based therapeutics were recognized as the necessary milestones for future investigations.

Identifiants

DOI: 10.1002/jev2.12305 PMID: 36775986 PMC: PMC9923045
pubmed: 36775986
doi: 10.1002/jev2.12305
pmc: PMC9923045
doi:

Substances chimiques

Nucleic Acids 0

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

e12305

Subventions

Organisme : NCI NIH HHS
ID : UH3 CA241694
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL150807
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB027078
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL128297
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL124074
Pays : United States
Organisme : NCATS NIH HHS
ID : UH3 TR002878
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL124021
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI144997
Pays : United States
Organisme : NIMH NIH HHS
ID : R33 MH118164
Pays : United States
Organisme : BLRD VA
ID : IK2 BX004097
Pays : United States
Organisme : NHLBI NIH HHS
ID : R56 HL141206
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA047807
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL141080
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB027062
Pays : United States

Commentaires et corrections

Type : ErratumIn

Informations de copyright

© 2023 The Authors. Journal of Extracellular Vesicles published by Wiley Periodicals, LLC on behalf of the International Society for Extracellular Vesicles.

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Auteurs

Guoping Li (G)

Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Tianji Chen (T)

Department of Pediatrics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA.

James Dahlman (J)

Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, Georgia, USA.

Lola Eniola-Adefeso (L)

Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA.

Ionita C Ghiran (IC)

Department of Anesthesia and Pain Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts, USA.

Peter Kurre (P)

Children's Hospital of Philadelphia, Comprehensive Bone Marrow Failure Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Wilbur A Lam (WA)

Wallace H. Coulter Department of Biomedical Engineering, Department of Pediatrics, Emory School of Medicine, Aflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta, Emory University and Georgia Institute of Technology, Atlanta, Georgia, USA.

Jennifer K Lang (JK)

Department of Medicine, Division of Cardiology, Jacobs School of Medicine and Biomedical Sciences, Veterans Affairs Western New York Healthcare System, Buffalo, New York, USA.

Eduardo Marbán (E)

Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Pilar Martín (P)

Centro Nacional de Investigaciones Cardiovasculares (CNIC), Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.

Stefan Momma (S)

Institute of Neurology (Edinger Institute), University Hospital, Goethe University, Frankfurt am Main, Germany.

Malcolm Moos (M)

Division of Cellular and Gene Therapies, Office of Tissues and Advanced Therapies, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Silver Spring, Maryland, USA.

Deborah J Nelson (DJ)

Department of Pharmacological and Physiological Sciences, The University of Chicago, Chicago, Illinois, USA.

Robert L Raffai (RL)

Department of Veterans Affairs, Surgical Service (112G), San Francisco VA Medical Center, San Francisco, California, USA.
Department of Surgery, Division of Vascular and Endovascular Surgery, University of California, San Francisco, California, USA.

Xi Ren (X)

Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.

Joost P G Sluijter (JPG)

Department of Experimental Cardiology, Circulatory Health Laboratory, Regenerative Medicine Centre, UMC Utrecht, University Utrecht, Utrecht, The Netherlands.

Shannon L Stott (SL)

Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts, USA.

Gordana Vunjak-Novakovic (G)

Department of Biomedical Engineering, Department of Medicine, Columbia University, New York, New York, USA.

Nykia D Walker (ND)

Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, Maryland, USA.

Zhenjia Wang (Z)

Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington, USA.

Kenneth W Witwer (KW)

Department of Molecular and Comparative Pathobiology, Department of Neurology and Neurosurgery, and The Richman Family Precision Medicine Center of Excellence in Alzheimer's Disease, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Phillip C Yang (PC)

Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.

Martha S Lundberg (MS)

Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.

Margaret J Ochocinska (MJ)

Division of Blood Diseases and Resources, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.

Renee Wong (R)

Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.

Guofei Zhou (G)

Division of Lung Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.

Stephen Y Chan (SY)

Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Division of Cardiology and Department of Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

Saumya Das (S)

Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Prithu Sundd (P)

Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Division of Pulmonary Allergy and Critical Care Medicine and Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

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