SLC-0111, an inhibitor of carbonic anhydrase IX, attenuates hepatoblastoma cell viability and migration.
carbonic anhydrase IX
hepatoblastoma
pediatric oncology
targeted therapy
tumor hypoxia
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2023
2023
Historique:
received:
07
12
2022
accepted:
13
01
2023
entrez:
13
2
2023
pubmed:
14
2
2023
medline:
14
2
2023
Statut:
epublish
Résumé
In response to hypoxia, tumor cells undergo transcriptional reprogramming including upregulation of carbonic anhydrase (CA) IX, a metalloenzyme that maintains acid-base balance. CAIX overexpression has been shown to correlate with poor prognosis in various cancers, but the role of this CA isoform in hepatoblastoma (HB) has not been examined. We surveyed the expression of CAIX in HB specimens and assessed the impact of SLC-0111, a CAIX inhibitor, on cultured HB cells in normoxic and hypoxic conditions. CAIX immunoreactivity was detected in 15 out of 21 archival pathology HB specimens. The CAIX-positive cells clustered in the middle of viable tumor tissue or next to necrotic areas. Tissue expression of Hypoxia induces CAIX expression in HB cells, and the CAIX inhibitor SLC-0111 has
Sections du résumé
Background
UNASSIGNED
In response to hypoxia, tumor cells undergo transcriptional reprogramming including upregulation of carbonic anhydrase (CA) IX, a metalloenzyme that maintains acid-base balance. CAIX overexpression has been shown to correlate with poor prognosis in various cancers, but the role of this CA isoform in hepatoblastoma (HB) has not been examined.
Methods
UNASSIGNED
We surveyed the expression of CAIX in HB specimens and assessed the impact of SLC-0111, a CAIX inhibitor, on cultured HB cells in normoxic and hypoxic conditions.
Results
UNASSIGNED
CAIX immunoreactivity was detected in 15 out of 21 archival pathology HB specimens. The CAIX-positive cells clustered in the middle of viable tumor tissue or next to necrotic areas. Tissue expression of
Conclusion
UNASSIGNED
Hypoxia induces CAIX expression in HB cells, and the CAIX inhibitor SLC-0111 has
Identifiants
pubmed: 36776327
doi: 10.3389/fonc.2023.1118268
pmc: PMC9909558
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1118268Informations de copyright
Copyright © 2023 Eloranta, Pihlajoki, Liljeström, Nousiainen, Soini, Lohi, Cairo, Wilson, Parkkila and Heikinheimo.
Déclaration de conflit d'intérêts
Author Stefano Cairo has formerly been employed by the company XenTech and is currently employed by the company Champions Oncology. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be constructed as a potential conflict of interest.
Références
Cancer Immunol Res. 2019 Jul;7(7):1064-1078
pubmed: 31088846
Neuro Oncol. 2012 Nov;14(11):1357-66
pubmed: 23074198
Pediatr Neonatol. 2021 Jul;62(4):400-405
pubmed: 33967009
Exp Cell Res. 2003 Nov 1;290(2):332-45
pubmed: 14567991
J Biol Chem. 2012 Jan 27;287(5):3392-402
pubmed: 22170054
NPJ Precis Oncol. 2020 Jul 7;4:20
pubmed: 32656360
Biochim Biophys Acta. 2009 Apr;1795(2):162-72
pubmed: 19344680
Oncoimmunology. 2018 Mar 26;7(7):e1445452
pubmed: 29900055
Br J Cancer. 2020 Jan;122(2):157-167
pubmed: 31819195
Mod Pathol. 2016 Sep;29(9):1038-49
pubmed: 27312064
Bioinformatics. 2015 Jan 15;31(2):166-9
pubmed: 25260700
Annu Rev Physiol. 2020 Feb 10;82:103-126
pubmed: 31730395
PLoS One. 2015 Mar 04;10(3):e0119181
pubmed: 25738958
Pediatr Transplant. 2013 Dec;17(8):744-50
pubmed: 23992390
J Enzyme Inhib Med Chem. 2020 Dec;35(1):1555-1561
pubmed: 32746643
Int J Mol Sci. 2020 Apr 23;21(8):
pubmed: 32340282
Metabolites. 2020 Oct 14;10(10):
pubmed: 33066524
Front Cell Dev Biol. 2020 Nov 09;8:602668
pubmed: 33240897
Pediatr Blood Cancer. 2020 Aug;67(8):e28350
pubmed: 32383794
BMC Bioinformatics. 2013 Apr 15;14:128
pubmed: 23586463
Radiother Oncol. 2005 Aug;76(2):187-93
pubmed: 16098620
Oncotarget. 2017 Aug 12;8(47):83088-83099
pubmed: 29137326
Cancer Med. 2017 Jan;6(1):288-297
pubmed: 28028936
Int J Mol Sci. 2019 Jun 04;20(11):
pubmed: 31167468
Tumour Biol. 2015 Dec;36(12):9517-24
pubmed: 26130414
Biostatistics. 2003 Apr;4(2):249-64
pubmed: 12925520
Oncogene. 1994 Oct;9(10):2877-88
pubmed: 8084592
Int J Oncol. 2016 Jan;48(1):271-80
pubmed: 26648580
Oncologist. 2004;9 Suppl 5:4-9
pubmed: 15591417
J Enzyme Inhib Med Chem. 2018 Dec;33(1):1024-1033
pubmed: 29865880
Nucleic Acids Res. 2014 Jul;42(Web Server issue):W26-31
pubmed: 24878925
Cancer Metastasis Rev. 2021 Dec;40(4):1035-1053
pubmed: 35080763
J Biol Chem. 2022 May;298(5):101885
pubmed: 35367211
Cancer Commun (Lond). 2019 Oct 24;39(1):62
pubmed: 31651371
Mol Carcinog. 2013 Aug;52(8):647-59
pubmed: 22488567
Oncol Rep. 2019 Apr;41(4):2585-2594
pubmed: 30720123
Hepatology. 2013 Jan;57(1):162-70
pubmed: 22898998
Cancers (Basel). 2020 Aug 15;12(8):
pubmed: 32824198
J Enzyme Inhib Med Chem. 2022 Dec;37(1):2635-2643
pubmed: 36146927
Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5
pubmed: 23193258
BMC Dev Biol. 2006 May 23;6:22
pubmed: 16719910
J Enzyme Inhib Med Chem. 2013 Apr;28(2):267-77
pubmed: 23137351
Bioinformatics. 2010 Jan 1;26(1):139-40
pubmed: 19910308
Virchows Arch. 2010 Jul;457(1):53-61
pubmed: 20526721
Oncol Lett. 2019 Jun;17(6):5030-5038
pubmed: 31186714
Pediatr Res. 2010 Apr;67(4):387-93
pubmed: 20032811
BMC Dev Biol. 2009 Mar 16;9:22
pubmed: 19291313
Gastroenterology. 1997 Feb;112(2):398-408
pubmed: 9024293
Nucleic Acids Res. 2019 Jul 2;47(W1):W357-W364
pubmed: 31106366
BMC Genomics. 2011 Oct 14;12:507
pubmed: 21999641
Cancers (Basel). 2022 Jul 06;14(14):
pubmed: 35884358
Virology. 1992 Apr;187(2):620-6
pubmed: 1312272
Cell Stem Cell. 2015 Mar 5;16(3):225-38
pubmed: 25748930
Cancer Res. 2011 May 1;71(9):3364-76
pubmed: 21415165
Methods. 2001 Dec;25(4):402-8
pubmed: 11846609
Nat Commun. 2021 Sep 20;12(1):5423
pubmed: 34538872
Oncogene. 2017 Nov 9;36(45):6244-6261
pubmed: 28692057
Pediatr Blood Cancer. 2012 Nov;59(5):776-9
pubmed: 22692949
Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):31-6
pubmed: 11134512
Nucleic Acids Res. 2016 Jul 8;44(W1):W90-7
pubmed: 27141961
Nat Methods. 2015 Apr;12(4):357-60
pubmed: 25751142
Eur J Cell Biol. 2010 Aug;89(8):598-606
pubmed: 20434230
Front Oncol. 2021 Nov 22;11:738607
pubmed: 34881176
Bioorg Med Chem Lett. 2015 Sep 15;25(18):3850-3
pubmed: 26233435
Oncotarget. 2017 Feb 21;8(8):13730-13746
pubmed: 28099149
Stat Appl Genet Mol Biol. 2004;3:Article3
pubmed: 16646809
Physiol Rev. 2022 Jul 1;102(3):1327-1383
pubmed: 35166161
J Cell Sci. 2011 Apr 1;124(Pt 7):1077-87
pubmed: 21363891
Int J Biochem Cell Biol. 2011 Feb;43(2):265-70
pubmed: 19646548
Oncogene. 2013 Oct 31;32(44):5210-9
pubmed: 23208505
Hypoxia (Auckl). 2015 Sep 18;3:35-43
pubmed: 27774480
J Indian Assoc Pediatr Surg. 2014 Oct;19(4):201-7
pubmed: 25336801
J Biotechnol. 2010 Jul 1;148(1):3-15
pubmed: 20097238
Oncotarget. 2017 Jan 3;8(1):1392-1404
pubmed: 27901496
J Natl Cancer Inst. 2001 Feb 21;93(4):266-76
pubmed: 11181773
J Enzyme Inhib Med Chem. 2020 Dec;35(1):391-397
pubmed: 31865754
Am J Clin Oncol. 2020 Jul;43(7):484-490
pubmed: 32251122
Hepatology. 2020 May;71(5):1626-1642
pubmed: 31479523