Clinical Correlation of Adenoviral Load in the Respiratory Tract Measured by Digital PCR in Immunocompromised Children.
adenovirus
children
digital PCR
immunocompromised
viral load
Journal
Open forum infectious diseases
ISSN: 2328-8957
Titre abrégé: Open Forum Infect Dis
Pays: United States
ID NLM: 101637045
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
received:
19
12
2022
accepted:
19
01
2023
entrez:
13
2
2023
pubmed:
14
2
2023
medline:
14
2
2023
Statut:
epublish
Résumé
Immunocompromised patients can have life-threatening adenoviral infection. Viral load in blood and stool is commonly used to guide antiviral therapy. We developed and evaluated a digital polymerase chain reaction assay to quantify human adenovirus in the respiratory tract and showed that higher peak load correlates with disseminated infection, mechanical ventilation, and death.
Identifiants
pubmed: 36776777
doi: 10.1093/ofid/ofad030
pii: ofad030
pmc: PMC9907548
doi:
Types de publication
Journal Article
Langues
eng
Pagination
ofad030Informations de copyright
© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
Déclaration de conflit d'intérêts
Potential conflicts of interest. R.H. has served as a consultant for Abbott Laboratories, Roche Diagnostics, T2 Diagnostics, and MiraVista Labs. G.M. receives research funding from SymBio Pharmaceuticals Inc. D.R.H., J.A.F., J.H., J.N.B., Z.G., S.S., H.L.G., K.J.A., M.P., R.H.D. have no conflicts of interest relevant to this article to disclose. All other authors report no potential conflicts.
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