The innate immune brakes of the lung.
airway allergy
homeostasis
immunoregulation
innate immunity
lung
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2023
2023
Historique:
received:
29
11
2022
accepted:
02
01
2023
entrez:
13
2
2023
pubmed:
14
2
2023
medline:
15
2
2023
Statut:
epublish
Résumé
Respiratory mucosal surfaces are continuously exposed to not only innocuous non-self antigens but also pathogen-associated molecular patterns (PAMPs) originating from environmental or symbiotic microbes. According to either "self/non-self" or "danger" models, this should systematically result in homeostasis breakdown and the development of immune responses directed to inhaled harmless antigens, such as T helper type (Th)2-mediated asthmatic reactions, which is fortunately not the case in most people. This discrepancy implies the existence, in the lung, of regulatory mechanisms that tightly control immune homeostasis. Although such mechanisms have been poorly investigated in comparison to the ones that trigger immune responses, a better understanding of them could be useful in the development of new therapeutic strategies against lung diseases (e.g., asthma). Here, we review current knowledge on innate immune cells that prevent the development of aberrant immune responses in the lung, thereby contributing to mucosal homeostasis.
Identifiants
pubmed: 36776895
doi: 10.3389/fimmu.2023.1111298
pmc: PMC9915150
doi:
Substances chimiques
Antigens
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1111298Informations de copyright
Copyright © 2023 Sabatel and Bureau.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Eur Respir J. 2005 Dec;26(6):1040-6
pubmed: 16319333
J Allergy Clin Immunol. 2019 Oct;144(4S):S4-S18
pubmed: 30468774
J Immunol Res. 2018 Apr 30;2018:5160794
pubmed: 29854841
J Gene Med. 2010 Mar;12(3):231-43
pubmed: 20140891
Int Immunopharmacol. 2021 Feb;91:107288
pubmed: 33360827
Front Immunol. 2020 Jun 04;11:1070
pubmed: 32582174
J Exp Med. 2004 Jul 5;200(1):89-98
pubmed: 15238608
Proc Natl Acad Sci U S A. 1978 Oct;75(10):5142-4
pubmed: 283421
Nat Commun. 2015 Feb 05;6:6219
pubmed: 25653051
Am J Pathol. 2007 Sep;171(3):928-37
pubmed: 17690184
Blood. 2013 May 16;121(20):4195-204
pubmed: 23509155
Am J Physiol Lung Cell Mol Physiol. 2006 May;290(5):L871-9
pubmed: 16603596
Results Probl Cell Differ. 2017;62:161-179
pubmed: 28455709
Cell. 2017 Sep 21;171(1):201-216.e18
pubmed: 28844693
J Clin Invest. 2016 Sep 1;126(9):3279-95
pubmed: 27548519
Annu Rev Immunol. 2003;21:685-711
pubmed: 12615891
Am J Pathol. 2004 Jan;164(1):263-71
pubmed: 14695339
Int Immunol. 2016 Oct;28(10):489-501
pubmed: 26976823
J Exp Med. 1993 Jun 1;177(6):1773-7
pubmed: 8496690
Reg Immunol. 1993 May-Aug;5(3-4):151-7
pubmed: 8240933
J Immunol. 2008 Jun 1;180(11):7318-26
pubmed: 18490731
Exp Mol Med. 2011 May 31;43(5):275-80
pubmed: 21415590
Int J Clin Pract. 2016 Jul;70(7):596-605
pubmed: 27352803
Nat Immunol. 2007 Oct;8(10):1095-104
pubmed: 17767162
Blood. 2006 Mar 1;107(5):2192-9
pubmed: 16249380
Annu Rev Immunol. 1994;12:991-1045
pubmed: 8011301
Front Immunol. 2017 Jul 13;8:819
pubmed: 28751894
Blood. 2010 Jul 1;115(26):5366-75
pubmed: 20357241
Am J Physiol Lung Cell Mol Physiol. 2017 Jun 1;312(6):L969-L982
pubmed: 28258108
J Immunol. 2016 Feb 15;196(4):1666-77
pubmed: 26746189
J Immunol. 1998 Jun 1;160(11):5300-8
pubmed: 9605128
Nat Med. 2009 Apr;15(4):410-6
pubmed: 19330007
Front Immunol. 2021 Sep 24;12:753940
pubmed: 34630433
Curr Opin Immunol. 2012 Jun;24(3):284-9
pubmed: 22521139
Toxicol Appl Pharmacol. 2006 Feb 15;211(1):20-9
pubmed: 15992840
Cells. 2020 Jan 26;9(2):
pubmed: 31991941
Nat Rev Immunol. 2013 Jan;13(1):9-22
pubmed: 23154224
J Exp Med. 2013 Apr 8;210(4):775-88
pubmed: 23547101
Arch Toxicol. 2006 Sep;80(9):561-71
pubmed: 16485118
Mucosal Immunol. 2010 Nov;3(6):578-93
pubmed: 20664577
Nat Immunol. 2001 Aug;2(8):725-31
pubmed: 11477409
Semin Immunol. 2005 Aug;17(4):295-303
pubmed: 15967679
Nature. 2006 Aug 31;442(7106):997-1002
pubmed: 16921386
Immunity. 2003 Jul;19(1):71-82
pubmed: 12871640
J Exp Med. 2014 May 5;211(5):943-59
pubmed: 24752301
J Immunol. 2004 Oct 1;173(7):4433-42
pubmed: 15383574
J Exp Med. 2007 Aug 6;204(8):1775-85
pubmed: 17620362
Nat Rev Immunol. 2021 Aug;21(8):485-498
pubmed: 33526920
Front Immunol. 2018 Jul 16;9:1655
pubmed: 30061902
Allergy. 2015 Jan;70(1):80-9
pubmed: 25331546
J Immunol. 2014 Mar 15;192(6):2821-9
pubmed: 24534529
J Clin Invest. 2009 Dec;119(12):3723-38
pubmed: 19907079
Am J Respir Cell Mol Biol. 2003 Nov;29(5):634-41
pubmed: 12777248
Cells. 2021 Oct 12;10(10):
pubmed: 34685700
J Immunol. 1994 Jan 1;152(1):351-60
pubmed: 8254203
J Immunol. 2003 Oct 15;171(8):3936-40
pubmed: 14530310
Nat Med. 1999 Oct;5(10):1150-6
pubmed: 10502818
Am J Respir Cell Mol Biol. 2002 Aug;27(2):257-64
pubmed: 12151319
Am J Physiol Lung Cell Mol Physiol. 2005 Oct;289(4):L627-35
pubmed: 15923207
Science. 2002 Apr 12;296(5566):301-5
pubmed: 11951032
Mucosal Immunol. 2013 May;6(3):485-97
pubmed: 22968421
Immunity. 2017 Mar 21;46(3):457-473
pubmed: 28329706
J Immunol. 2013 Jul 1;191(1):25-9
pubmed: 23733880
J Immunol. 2004 Sep 15;173(6):3748-54
pubmed: 15356121
Mucosal Immunol. 2013 May;6(3):464-73
pubmed: 23549447
Crit Rev Immunol. 2018;38(4):303-331
pubmed: 30806245
J Exp Med. 2000 Nov 6;192(9):1213-22
pubmed: 11067871
Immunity. 2013 Sep 19;39(3):599-610
pubmed: 24012416
Immunity. 2021 May 11;54(5):875-884
pubmed: 33979585
BMJ. 1989 Nov 18;299(6710):1259-60
pubmed: 2513902
Immunity. 2016 Sep 20;45(3):626-640
pubmed: 27637148
Am J Respir Cell Mol Biol. 2005 Mar;32(3):177-84
pubmed: 15576669
J Allergy Clin Immunol. 2007 May;119(5):1241-50
pubmed: 17353041
Immunity. 2015 Jun 16;42(6):1130-42
pubmed: 26070484
Nat Rev Immunol. 2008 Mar;8(3):193-204
pubmed: 18301423
J Allergy Clin Immunol. 2017 Jul;140(1):280-283.e3
pubmed: 28007476
Immunity. 2015 Nov 17;43(5):945-58
pubmed: 26588780
J Immunol. 2001 Feb 1;166(3):1471-81
pubmed: 11160186
Eur J Immunol. 2004 Jul;34(7):1817-27
pubmed: 15214030
J Exp Med. 1998 Jun 15;187(12):2045-53
pubmed: 9625764
Cancer Immunol Res. 2017 Jan;5(1):3-8
pubmed: 28052991
Immunol Res. 2011 Aug;50(2-3):153-8
pubmed: 21717065
JCI Insight. 2017 May 18;2(10):
pubmed: 28515363
J Clin Invest. 2012 Mar;122(3):1082-96
pubmed: 22307326
Nat Rev Immunol. 2014 Feb;14(2):81-93
pubmed: 24445666
J Immunol. 2013 Oct 1;191(7):3818-26
pubmed: 23997221
J Exp Med. 1989 Aug 1;170(2):499-509
pubmed: 2526847
Immunity. 2022 Sep 13;55(9):1564-1580
pubmed: 36103853
Blood. 2010 Mar 11;115(10):1958-68
pubmed: 20068222
Science. 2015 Sep 4;349(6252):1106-10
pubmed: 26339029
J Allergy Clin Immunol. 2019 Jun;143(6):2190-2201.e9
pubmed: 30682454
Immunol Rev. 2022 Nov 20;:
pubmed: 36404627
J Exp Med. 2022 Feb 7;219(2):
pubmed: 35019940
Nat Rev Immunol. 2017 Dec;17(12):746-760
pubmed: 28891557
Immunology. 1995 Jan;84(1):142-7
pubmed: 7534261
Respir Res. 2004 Nov 11;5:21
pubmed: 15538945
Front Immunol. 2018 Jul 31;9:1777
pubmed: 30108592
Science. 1998 May 22;280(5367):1265-7
pubmed: 9596580
Sci Immunol. 2022 Jul 15;7(73):eabn3240
pubmed: 35857578
J Immunol. 2006 Apr 1;176(7):4141-6
pubmed: 16547250
Mucosal Immunol. 2022 Feb;15(2):223-234
pubmed: 35017701
J Immunol. 2008 Nov 15;181(10):7230-42
pubmed: 18981145
Nat Immunol. 2017 Dec;18(12):1310-1320
pubmed: 29035391
Int Immunol. 2002 Jun;14(6):659-67
pubmed: 12039917
J Immunol. 2022 Mar 1;208(5):1272-1279
pubmed: 35110420
J Leukoc Biol. 1993 Apr;53(4):366-71
pubmed: 8482916
Sci Immunol. 2020 Mar 27;5(45):
pubmed: 32220976
J Immunol. 2014 Oct 15;193(8):4245-53
pubmed: 25225663
Nat Rev Immunol. 2008 Jun;8(6):478-86
pubmed: 18483499
J Exp Med. 2007 Jan 22;204(1):105-15
pubmed: 17200410
J Immunol. 2016 Nov 1;197(9):3725-3734
pubmed: 27707998
Immunity. 2021 Feb 9;54(2):259-275.e7
pubmed: 33382972
Ann Allergy Asthma Immunol. 2004 May;92(5):538-44
pubmed: 15191022
Blood. 2002 Jul 15;100(2):383-90
pubmed: 12091326
Respir Res. 2006 Jan 06;7:4
pubmed: 16398938
J Exp Med. 2015 May 4;212(5):729-42
pubmed: 25847945
Mucosal Immunol. 2016 Jan;9(1):275-86
pubmed: 26129648
Immunity. 2020 Jun 16;52(6):1039-1056.e9
pubmed: 32392463
J Immunol. 2009 Jul 15;183(2):1074-82
pubmed: 19553531
Am J Respir Cell Mol Biol. 2017 Jul;57(1):66-76
pubmed: 28257233
N Engl J Med. 2011 Feb 24;364(8):701-9
pubmed: 21345099
J Immunol. 1996 Oct 1;157(7):3097-104
pubmed: 8816420
J Clin Invest. 2014 Mar;124(3):1130-43
pubmed: 24569377
J Immunol. 2014 May 1;192(9):4453-4464
pubmed: 24688024
J Clin Invest. 2012 Jan;122(1):327-36
pubmed: 22156198
Cell Immunol. 2018 Aug;330:91-96
pubmed: 29458975
Am J Respir Cell Mol Biol. 2022 Aug;67(2):241-252
pubmed: 35522264
N Engl J Med. 2002 Sep 19;347(12):869-77
pubmed: 12239255
J Allergy Clin Immunol. 2001 Feb;107(2):258-64
pubmed: 11174191
Science. 2019 Mar 15;363(6432):
pubmed: 30872492
J Immunol. 2005 Jan 15;174(2):854-63
pubmed: 15634907
J Exp Med. 2007 Aug 6;204(8):1757-64
pubmed: 17620361
Am J Respir Cell Mol Biol. 2013 Jun;48(6):773-80
pubmed: 23492186
J Allergy Clin Immunol. 2021 Mar;147(3):1087-1092.e3
pubmed: 33065121
Clin Exp Allergy. 1992 Dec;22(12):1107-14
pubmed: 1486539
Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11810-5
pubmed: 25074917
JCI Insight. 2017 Dec 21;2(24):
pubmed: 29263310
Nature. 2014 Feb 27;506(7489):503-6
pubmed: 24463523
Nat Commun. 2019 Sep 3;10(1):3964
pubmed: 31481690
Respir Res. 2010 Sep 15;11:124
pubmed: 20843333
J Allergy Clin Immunol. 2015 Jul;136(1):38-48
pubmed: 25457152
J Immunol. 2008 Jan 15;180(2):817-24
pubmed: 18178820
Biochem Pharmacol. 2023 Jan;207:115348
pubmed: 36400250
J Leukoc Biol. 2000 Apr;67(4):545-52
pubmed: 10770288
Clin Exp Allergy. 2000 Sep;30(9):1230-4
pubmed: 10971468
J Immunol. 2010 Dec 15;185(12):7165-73
pubmed: 21078911
J Exp Med. 2018 Nov 5;215(11):2725-2736
pubmed: 30355614
J Exp Med. 1993 Feb 1;177(2):397-407
pubmed: 8426110
Nat Med. 2002 Sep;8(9):1024-32
pubmed: 12145647
Inflamm Res. 2005 Dec;54(12):514-21
pubmed: 16389573
J Exp Med. 2017 May 1;214(5):1249-1258
pubmed: 28385925
J Immunol. 2011 Nov 1;187(9):4800-8
pubmed: 21930959
Immunology. 1996 Feb;87(2):250-8
pubmed: 8698387
Blood. 2005 Feb 1;105(3):1162-9
pubmed: 15479730