Pacing interventions in non-responders to cardiac resynchronization therapy.
CRT
CRT non-response
conduction system pacing
endocardial pacing
leadless cardiac resynchronization therapy
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2023
2023
Historique:
received:
26
09
2022
accepted:
17
01
2023
entrez:
13
2
2023
pubmed:
14
2
2023
medline:
14
2
2023
Statut:
epublish
Résumé
Non-responders to Cardiac Resynchronization Therapy (CRT) represent a high-risk, and difficult to treat population of heart failure patients. Studies have shown that these patients have a lower quality of life and reduced life expectancy compared to those who respond to CRT. Whilst the first-line treatment for dyssynchronous heart failure is "conventional" biventricular epicardial CRT, a range of novel pacing interventions have emerged as potential alternatives. This has raised the question whether these new treatments may be useful as a second-line pacing intervention for treating non-responders, or indeed, whether some patients may benefit from these as a first-line option. In this review, we will examine the current evidence for four pacing interventions in the context of treatment of conventional CRT non-responders: CRT optimization; multisite left ventricular pacing; left ventricular endocardial pacing and conduction system pacing.
Identifiants
pubmed: 36776979
doi: 10.3389/fphys.2023.1054095
pii: 1054095
pmc: PMC9909021
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1054095Informations de copyright
Copyright © 2023 Wijesuriya, Elliott, Mehta, De Vere, Strocchi, Behar, Niederer and Rinaldi.
Déclaration de conflit d'intérêts
NW, ME, VM, FD, JB, and CR were employed by the Guy’s and St Thomas’ NHS Foundation Trust. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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