Developmental language disorders in preschool children after high exposure to perfluoroalkyl substances from contaminated drinking water in Ronneby, Sweden.
Developmental language disorder
Early-life exposure
Perfluorohexane sulfonic acid (PFHxS)
Perfluorooctane sulfonic acid (PFOS)
Register-based cohort study
Journal
Environmental epidemiology (Philadelphia, Pa.)
ISSN: 2474-7882
Titre abrégé: Environ Epidemiol
Pays: United States
ID NLM: 101719527
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
received:
16
09
2022
accepted:
01
11
2022
entrez:
13
2
2023
pubmed:
14
2
2023
medline:
14
2
2023
Statut:
epublish
Résumé
There are indications that early-life exposure to perfluoroalkyl substances (PFAS) can impact neurodevelopment, but results are inconclusive. The objective was to investigate if high early-life exposure to primarily perfluorohexanesulfonic acid (PFHxS) and perfluorooctanesulfonic acid (PFOS) increases the risk of developmental language disorder in children up to seven years of age. A register-based cohort of all children born 1998-2013 in Blekinge county, Sweden, was studied. Maternal residential history, that is, with or without highly PFAS-contaminated drinking water, during the 5-year period before childbirth was used as a proxy for early-life exposure. Exposure was categorized as high (n = 646), intermediate (n = 1,650), or background (n = 9,599). We used Cox proportional hazards regression to estimate hazard ratios (HR) for (1) referral to a speech- and language pathologist after routine screening at Child Health Services, and (2) subsequent language disorder diagnosis after clinical assessment. Models were adjusted for parity, maternal age, education level, and smoking, and explored effect modification by sex. In children from the high-exposed area, the adjusted HR for referral was 1.23 (95% CI = 1.03, 1.47) and 1.13 (95% CI = 0.97, 1.56) for subsequent diagnosis. There was no increased risk in the intermediate exposure category. Children, particularly girls, with high exposure had an increased risk of both referral and confirmed developmental language disorder. Further research is needed on PFAS in the context of general neurodevelopment, for which language development is a proxy.
Identifiants
pubmed: 36777530
doi: 10.1097/EE9.0000000000000233
pmc: PMC9916036
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e233Informations de copyright
Copyright © 2022 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The Environmental Epidemiology. All rights reserved.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest with regard to the content of this report.
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