Chromosome 10q24.32 Variants Associate with Brain Arterial Diameters in Diverse Populations: A Genome-Wide Association Study.

Chromosome 10q24.32 Cyclin and CBS Domain Divalent Metal Cation Transport Mediator 2 (CNNM2) Genome-wide association studies Larger brain arterial diameters

Journal

medRxiv : the preprint server for health sciences
Titre abrégé: medRxiv
Pays: United States
ID NLM: 101767986

Informations de publication

Date de publication:
15 Feb 2023
Historique:
pubmed: 14 2 2023
medline: 14 2 2023
entrez: 13 2 2023
Statut: epublish

Résumé

Brain arterial diameters are novel imaging biomarkers of cerebrovascular disease, cognitive decline and dementia. Traditional vascular risk factors have been associated with brain arterial diameters but whether there may be genetic determinants of brain arterial diameters is unknown. We studied 4150 participants from six geographically diverse population-based cohorts (40% European, 14% African, 22% Hispanic, 24% Asian ancestries). We measured brain arterial diameters for 13 segments and averaged them to obtain a global measure of brain arterial diameters as well as the posterior and anterior circulations. A genome-wide association study (GWAS) revealed 14 variants at one locus associated with global brain arterial diameter at genome-wide significance (P<5×10 Our study reveals three novel risk loci (CNNM2, NT5C2 and AS3MT) associated with brain arterial diameters. Our finding may elucidate the mechanisms by which brain arterial diameters influence the risk of stroke and dementia.

Sections du résumé

Background UNASSIGNED
Brain arterial diameters are novel imaging biomarkers of cerebrovascular disease, cognitive decline and dementia. Traditional vascular risk factors have been associated with brain arterial diameters but whether there may be genetic determinants of brain arterial diameters is unknown.
Results UNASSIGNED
We studied 4150 participants from six geographically diverse population-based cohorts (40% European, 14% African, 22% Hispanic, 24% Asian ancestries). We measured brain arterial diameters for 13 segments and averaged them to obtain a global measure of brain arterial diameters as well as the posterior and anterior circulations. A genome-wide association study (GWAS) revealed 14 variants at one locus associated with global brain arterial diameter at genome-wide significance (P<5×10
Conclusion UNASSIGNED
Our study reveals three novel risk loci (CNNM2, NT5C2 and AS3MT) associated with brain arterial diameters. Our finding may elucidate the mechanisms by which brain arterial diameters influence the risk of stroke and dementia.

Identifiants

DOI: 10.1101/2023.01.31.23285251 PMID: 36778463 PMC: PMC9915818
pubmed: 36778463
doi: 10.1101/2023.01.31.23285251
pmc: PMC9915818
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NIA NIH HHS
ID : R01 AG054491
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL096812
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL096917
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL086694
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL096902
Pays : United States
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Organisme : NIA NIH HHS
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Organisme : NHLBI NIH HHS
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Pays : United States
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ID : R01 AG047645
Pays : United States
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ID : R01 NS029993
Pays : United States
Organisme : NHLBI NIH HHS
ID : 75N92022D00005
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC25195
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL087641
Pays : United States
Organisme : NHLBI NIH HHS
ID : 75N92022D00001
Pays : United States
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ID : UL1 RR025005
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL131029
Pays : United States
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Pays : United States
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Organisme : NHLBI NIH HHS
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Pays : United States
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Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS036286
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG072474
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG066162
Pays : United States

Commentaires et corrections

Type : UpdateIn

Auteurs

Minghua Liu (M)

Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.

Farid Khasiyev (F)

Department of Neurology, Saint Louis University School of Medicine, St. Louis, MO, USA.

Sanjeev Sariya (S)

Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
The Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.

Antonio Spagnolo-Allende (A)

Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.

Danurys L Sanchez (DL)

Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
The Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.

Howard Andrews (H)

Biostatistics Department, Mailman School of Public Health, Columbia University, New York, NY, USA.

Qiong Yang (Q)

Department of Biostatistics, School of Public Health, Boston University, Boston, MA, USA.

Alexa Beiser (A)

Department of Biostatistics, School of Public Health, Boston University, Boston, MA, USA.

Ye Qiao (Y)

Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Emy A Thomas (EA)

Brown Foundation Institute of Molecular Medicine, Mc Govern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.

Jose Rafael Romero (JR)

Department of Neurology, Boston University School of Medicine, Boston, MA, USA.

Tatjana Rundek (T)

Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA.
Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.
Evelyn F. McKnight Brain Institute, University of Miami Miller School of Medicine, Miami, FL, USA.

Adam M Brickman (AM)

Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
The Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.

Jennifer J Manly (JJ)

Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
The Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.

Mitchell Sv Elkind (MS)

Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.

Sudha Seshadri (S)

Department of Neurology, Boston University School of Medicine, Boston, MA, USA.
The Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA.

Christopher Chen (C)

Memory Aging and Cognition Center, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Ralph L Sacco (RL)

Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA.
Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.
Evelyn F. McKnight Brain Institute, University of Miami Miller School of Medicine, Miami, FL, USA.

Saima Hilal (S)

Memory Aging and Cognition Center, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Bruce A Wasserman (BA)

Johns Hopkins University School of Medicine, Baltimore, MD, USA.
University of Maryland School of Medicine, Baltimore, MD, USA.

Giuseppe Tosto (G)

Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
The Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.

Myriam Fornage (M)

Brown Foundation Institute of Molecular Medicine, Mc Govern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.

Jose Gutierrez (J)

Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.

Classifications MeSH