Hypermetabolism in mice carrying a near complete human chromosome 21.
Journal
bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187
Informations de publication
Date de publication:
31 Jan 2023
31 Jan 2023
Historique:
entrez:
13
2
2023
pubmed:
14
2
2023
medline:
14
2
2023
Statut:
epublish
Résumé
The consequences of aneuploidy have traditionally been studied in cell and animal models in which the extrachromosomal DNA is from the same species. Here, we explore a fundamental question concerning the impact of aneuploidy on systemic metabolism using a non-mosaic transchromosomic mouse model (TcMAC21) carrying a near complete human chromosome 21. Independent of diets and housing temperatures, TcMAC21 mice consume more calories, are hyperactive and hypermetabolic, remain consistently lean and profoundly insulin sensitive, and have a higher body temperature. The hypermetabolism and elevated thermogenesis are due to sarcolipin overexpression in the skeletal muscle, resulting in futile sarco(endo)plasmic reticulum Ca
Identifiants
pubmed: 36778465
doi: 10.1101/2023.01.30.526183
pmc: PMC9915508
pii:
doi:
Types de publication
Preprint
Langues
eng
Commentaires et corrections
Type : UpdateIn
Références
Am J Hum Genet. 2022 Feb 3;109(2):328-344
pubmed: 35077668
Nat Biotechnol. 2019 Aug;37(8):907-915
pubmed: 31375807
J Biol Chem. 2015 May 29;290(22):14057-67
pubmed: 25882845
Free Radic Biol Med. 2018 Jan;114:122-130
pubmed: 28958596
Cell Calcium. 2012 Jul;52(1):28-35
pubmed: 22502861
Diabetologia. 2004 Jan;47(1):47-54
pubmed: 14673524
Nat Med. 2012 Oct;18(10):1575-9
pubmed: 22961106
Obesity (Silver Spring). 2016 Jul;24(7):1499-505
pubmed: 27345961
Am J Physiol Cell Physiol. 2022 Mar 1;322(3):C382-C394
pubmed: 35044855
Nat Med. 2000 Oct;6(10):1115-20
pubmed: 11017142
Nat Rev Genet. 2017 Mar;18(3):147-163
pubmed: 28029161
Philos Trans R Soc Lond B Biol Sci. 2020 Mar 2;375(1793):20190135
pubmed: 31928193
Bioinformatics. 2014 Apr 1;30(7):923-30
pubmed: 24227677
BMC Endocr Disord. 2005 Jun 17;5:6
pubmed: 15963228
Autophagy. 2019 Jan;15(1):131-150
pubmed: 30209975
FASEB J. 2013 Sep;27(9):3871-8
pubmed: 23752204
Am J Physiol Endocrinol Metab. 2016 Oct 1;311(4):E678-E697
pubmed: 27555298
Cell Metab. 2019 Jan 8;29(1):27-37
pubmed: 30503034
Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):8649-8654
pubmed: 28739898
EMBO J. 1998 Sep 1;17(17):4987-5000
pubmed: 9724635
Obesity (Silver Spring). 2015 Jul;23(7):1440-9
pubmed: 25970801
Nature. 2000 Jul 27;406(6794):415-8
pubmed: 10935638
Nat Med. 2017 Dec;23(12):1454-1465
pubmed: 29131158
OMICS. 2012 May;16(5):284-7
pubmed: 22455463
Arch Dis Child. 1997 Aug;77(2):186
pubmed: 9301372
J Mol Cell Cardiol. 2007 Aug;43(2):215-22
pubmed: 17561107
Front Neurosci. 2020 Jul 08;14:670
pubmed: 32733190
Proc Natl Acad Sci U S A. 2020 Sep 8;117(36):22544-22551
pubmed: 32826330
Biochem J. 2005 Jul 1;389(Pt 1):151-9
pubmed: 15801907
Dis Model Mech. 2022 Dec 1;15(12):
pubmed: 36374158
Mamm Genome. 2016 Dec;27(11-12):538-555
pubmed: 27538963
Nat Protoc. 2008;3(6):1101-8
pubmed: 18546601
Nat Rev Dis Primers. 2020 Feb 6;6(1):9
pubmed: 32029743
Proc Natl Acad Sci U S A. 1994 May 24;91(11):4997-5001
pubmed: 8197171
Biochem J. 2020 Feb 14;477(3):709-725
pubmed: 32059055
PLoS One. 2013 Dec 16;8(12):e84304
pubmed: 24358354
J Biol Chem. 2006 Dec 1;281(48):36597-602
pubmed: 17018526
Sci Adv. 2021 Nov 26;7(48):eabi7154
pubmed: 34826239
J Biol Chem. 2015 Apr 24;290(17):10840-9
pubmed: 25713078
Eur J Appl Physiol. 2010 Nov;110(4):665-94
pubmed: 20602111
Front Physiol. 2018 Jun 14;9:714
pubmed: 29962960
Cell Rep. 2018 Sep 11;24(11):2919-2931
pubmed: 30208317
J Biol Chem. 2013 Mar 8;288(10):6881-9
pubmed: 23341466
Res Dev Disabil. 2016 Oct;57:181-92
pubmed: 27448331
Genome Biol. 2014 Feb 03;15(2):R29
pubmed: 24485249
Biol Rev Camb Philos Soc. 2015 Nov;90(4):1279-97
pubmed: 25424279
Mamm Genome. 2011 Dec;22(11-12):685-91
pubmed: 21953412
Elife. 2020 Jun 29;9:
pubmed: 32597754
Front Behav Neurosci. 2016 Jun 14;10:120
pubmed: 27378871
Dev Cell. 2018 Feb 26;44(4):420-431
pubmed: 29486194
Arch Environ Health. 1968 Sep;17(3):372-6
pubmed: 4233868
Annu Rev Biochem. 2004;73:269-92
pubmed: 15189143
J Clin Invest. 1990 Nov;86(5):1423-7
pubmed: 2243122
Cell. 2015 Oct 22;163(3):643-55
pubmed: 26496606
Physiol Rev. 1997 Jul;77(3):731-58
pubmed: 9234964
PLoS One. 2013 Apr 15;8(4):e60482
pubmed: 23596509
Cell Rep. 2019 Jun 11;27(11):3385-3400.e3
pubmed: 31189119
Physiol Rep. 2015 Sep;3(9):
pubmed: 26400985
Hum Mol Genet. 2007 Jun 1;16(11):1359-66
pubmed: 17412756
J Biol Chem. 2016 Aug 12;291(33):17247-57
pubmed: 27298322
Dis Model Mech. 2017 Oct 1;10(10):1165-1186
pubmed: 28993310
J Biol Chem. 2015 May 8;290(19):12282-9
pubmed: 25825499
Nat Metab. 2021 Mar;3(3):378-393
pubmed: 33686286
Biochemistry. 2013 Apr 23;52(16):2793-809
pubmed: 23547908
Biochem J. 2002 Jan 15;361(Pt 2):277-86
pubmed: 11772399
PLoS One. 2013 Jul 01;8(7):e68924
pubmed: 23840903
Mol Metab. 2018 Jan;7:45-56
pubmed: 29175051
Physiol Rev. 2014 Apr;94(2):355-82
pubmed: 24692351
Diabetologia. 1985 Jul;28(7):412-9
pubmed: 3899825
Am J Physiol Endocrinol Metab. 2020 Dec 1;319(6):E1084-E1100
pubmed: 33017221
Science. 2005 Sep 23;309(5743):2033-7
pubmed: 16179473
Nat Methods. 2012 Jul;9(7):671-5
pubmed: 22930834
J Exp Biol. 2015 Aug;218(Pt 15):2321-5
pubmed: 26026037
Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13807-12
pubmed: 10570154
EMBO J. 2020 Jul 1;39(13):e104073
pubmed: 32432379
Mamm Genome. 2011 Dec;22(11-12):674-84
pubmed: 21953411
Mol Metab. 2023 Feb;68:101666
pubmed: 36587842
J Appl Physiol (1985). 2015 Apr 15;118(8):1050-8
pubmed: 25701006