Homodecameric Rad52 promotes single-position Rad51 nucleation in homologous recombination.


Journal

bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187

Informations de publication

Date de publication:
06 Jun 2023
Historique:
pubmed: 14 2 2023
medline: 14 2 2023
entrez: 13 2 2023
Statut: epublish

Résumé

Homologous recombination (HR) is a pathway for the accurate repair of double-stranded DNA breaks. These breaks are resected to yield single-stranded DNA (ssDNA) that are coated by Replication Protein A (RPA).

Identifiants

pubmed: 36778491
doi: 10.1101/2023.02.05.527205
pmc: PMC9915710
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM130746
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM133967
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM149320
Pays : United States
Organisme : NIH HHS
ID : S10 OD030343
Pays : United States

Déclaration de conflit d'intérêts

Competing interests The authors declare no competing interests.

Auteurs

Jaigeeth Deveryshetty (J)

Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, MO.

Rahul Chadda (R)

Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, MO.

Jenna Mattice (J)

Department of Chemistry and Biochemistry, Montana State University, Bozeman, MT.

Simrithaa Karunakaran (S)

Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, MO.

Michael J Rau (MJ)

Center for Cellular Imaging, Washington University in St. Louis School of Medicine, St. Louis, MO.

Katherine Basore (K)

Center for Cellular Imaging, Washington University in St. Louis School of Medicine, St. Louis, MO.

Nilisha Pokhrel (N)

Department of Biological Sciences, Marquette University, Milwaukee, WI (Present address: Aera Therapeutics, Boston, MA, USA).

Noah Englander (N)

Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, MO.

James A J Fitzpatrick (JAJ)

Center for Cellular Imaging, Washington University in St. Louis School of Medicine, St. Louis, MO.

Brian Bothner (B)

Department of Chemistry and Biochemistry, Montana State University, Bozeman, MT.

Edwin Antony (E)

Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, MO.

Classifications MeSH