Fulminant myocarditis with complete atrioventricular block after mRNA COVID-19 vaccination: A case report.
BNT162b2
Complete atrioventricular block
Coronavirus disease 2019
Eosinophilic myocarditis
Hypersensitivity myocarditis
mRNA
Journal
Journal of cardiology cases
ISSN: 1878-5409
Titre abrégé: J Cardiol Cases
Pays: Japan
ID NLM: 101549579
Informations de publication
Date de publication:
May 2023
May 2023
Historique:
received:
09
08
2022
revised:
20
12
2022
accepted:
04
01
2023
medline:
14
2
2023
pubmed:
14
2
2023
entrez:
13
2
2023
Statut:
ppublish
Résumé
A 71-year-old man was transferred urgently to our hospital after collapsing near his home post the first shot of the BNT162b2 coronavirus disease 2019 vaccine (Pfizer-BioNTech, Comirnaty®). Immediately after arrival at our hospital, cardiac arrest due to complete atrioventricular block with no ventricular escaped beats was observed on electrocardiogram. Echocardiography showed preserved left ventricular ejection fraction, however, diffuse severe hypokinesia was revealed after 3 weeks, and he died 3 months after admission because of worsening heart failure. An autopsy examination revealed eosinophilic myocarditis or hypersensitivity myocarditis with extensive fibrosis and widespread myocardial dropout throughout the heart. 1. Severe myocarditis occurs extremely rarely after mRNA coronavirus disease 2019 (COVID-19) vaccination. 2. Myocarditis after mRNA COVID-19 vaccination might cause complete atrioventricular block, followed by a course of decreased left ventricular ejection fraction. 3. Histologically, severe myocarditis after mRNA COVID-19 vaccination seems to present as fulminant necrotizing eosinophilic myocarditis or hypersensitivity myocarditis.
Identifiants
pubmed: 36779079
doi: 10.1016/j.jccase.2023.01.004
pii: S1878-5409(23)00005-1
pmc: PMC9906563
doi:
Types de publication
Case Reports
Langues
eng
Pagination
229-232Informations de copyright
© 2023 Japanese College of Cardiology. Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
None.
Références
Drugs. 2021 Mar;81(4):495-501
pubmed: 33683637
JAMA. 2022 Jan 25;327(4):331-340
pubmed: 35076665
Kardiol Pol. 2022;80(1):109-110
pubmed: 34856634
Ann Med Surg (Lond). 2021 Nov;71:102956
pubmed: 34667594
Expert Rev Vaccines. 2022 Jan;21(1):83-89
pubmed: 34738500
J Am Coll Cardiol. 2017 Nov 7;70(19):2363-2375
pubmed: 29096807
Arch Pathol Lab Med. 2022 Aug 1;146(8):925-929
pubmed: 35157759
Circ Res. 2017 Sep 15;121(7):803-818
pubmed: 28912184
J Clin Immunol. 2022 Apr;42(3):441-447
pubmed: 34978002
J Cardiol Cases. 2021 Jan;23(1):27-30
pubmed: 32904735