Tramadol as a Voltage-Gated Sodium Channel Blocker of Peripheral Sodium Channels Na
Local anesthetic
Pain
Sodium channel
Tramadol
Journal
Biomolecules & therapeutics
ISSN: 1976-9148
Titre abrégé: Biomol Ther (Seoul)
Pays: Korea (South)
ID NLM: 101472832
Informations de publication
Date de publication:
01 Mar 2023
01 Mar 2023
Historique:
received:
06
01
2023
revised:
16
01
2023
accepted:
17
01
2023
pubmed:
14
2
2023
medline:
14
2
2023
entrez:
13
2
2023
Statut:
ppublish
Résumé
Tramadol is an opioid analog used to treat chronic and acute pain. Intradermal injections of tramadol at hundreds of millimoles have been shown to produce a local anesthetic effect. We used the whole-cell patch-clamp technique in this study to investigate whether tramadol blocks the sodium current in HEK293 cells, which stably express the pain threshold sodium channel Na
Identifiants
pubmed: 36779240
pii: biomolther.2023.002
doi: 10.4062/biomolther.2023.002
pmc: PMC9970842
doi:
Types de publication
Journal Article
Langues
eng
Pagination
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