[Production of innervated bronchial epithelium from a blood sample].
Fabrication d’un épithélium bronchique innervé à partir d’une prise de sang.
Asthma
Asthme
Bronchial epithelium
Cellules souches pluripotentes induites
Induced pluripotent stem cells
Inflammation neurogène
Innervation sensitive
Neurogenic inflammation
Sensory innervation
Épithélium bronchique
Journal
Revue des maladies respiratoires
ISSN: 1776-2588
Titre abrégé: Rev Mal Respir
Pays: France
ID NLM: 8408032
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
received:
05
01
2023
accepted:
06
01
2023
pubmed:
14
2
2023
medline:
28
3
2023
entrez:
13
2
2023
Statut:
ppublish
Résumé
Asthma is a frequent respiratory disease, with severe asthma occurring in 3 to 5% of cases. Chronic inflammation of the bronchial epithelium is essential to its pathophysiology. When activated by the bronchial environment, the peripheral sensory nervous system contributes to inflammation of the airways. However, due to a lack of reliable models, the mechanisms of action remain largely unknown. Using induced pluripotent stem cells reprogrammed from blood cells, we have set up a model of bronchial epithelium innervated by sensory neurons. This model will ensure better understanding of the mechanisms of action underlying neurogenic inflammation.
Identifiants
pubmed: 36781344
pii: S0761-8425(23)00044-X
doi: 10.1016/j.rmr.2023.01.021
pii:
doi:
Types de publication
English Abstract
Journal Article
Langues
fre
Sous-ensembles de citation
IM
Pagination
247-249Informations de copyright
Copyright © 2023 SPLF. Published by Elsevier Masson SAS. All rights reserved.