Influence of deoxynivalenol-contaminated feed on the immune response of pigs after PRRSV vaccination and infection.
CD4+ T cells
Deoxynivalenol
Infection
PRRSV
Pig
Vaccination
Journal
Archives of toxicology
ISSN: 1432-0738
Titre abrégé: Arch Toxicol
Pays: Germany
ID NLM: 0417615
Informations de publication
Date de publication:
04 2023
04 2023
Historique:
received:
01
10
2022
accepted:
24
01
2023
pubmed:
14
2
2023
medline:
22
3
2023
entrez:
13
2
2023
Statut:
ppublish
Résumé
The impact of the Fusarium mycotoxin deoxynivalenol (DON) on the immune response against porcine reproductive and respiratory syndrome virus (PRRSV) vaccination and infection was investigated. Forty-two weaned piglets were separated into seven groups and received three different diets: Low DON (1.09 ppm), High DON (2.81 ppm) or No DON. These three treatments were split further into either vaccinated (Ingelvac PRRSFLEX EU) and challenged with PRRSV 28 days post-vaccination, or only infected at day 28. A seventh group received no DON, no vaccination, and no infection. Two weeks after challenge infection, when pigs were euthanized, the number of IFN-γ producing lymphocytes in the blood of vaccinated animals was lower in pigs on High DON compared to animals on Low DON or No DON. Intracellular cytokine staining showed that vaccinated animals fed with the Low DON diet had higher frequencies of TNF-α/IFN-γ co-producing CD4
Identifiants
pubmed: 36781434
doi: 10.1007/s00204-023-03449-9
pii: 10.1007/s00204-023-03449-9
pmc: PMC10025202
doi:
Substances chimiques
deoxynivalenol
JT37HYP23V
Tumor Necrosis Factor-alpha
0
Antibodies, Viral
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1079-1089Subventions
Organisme : Österreichische Forschungsförderungsgesellschaft
ID : 855707
Informations de copyright
© 2023. The Author(s).
Références
Semin Immunol. 2009 Apr;21(2):84-91
pubmed: 19298946
Vet J. 2006 Nov;172(3):506-14
pubmed: 16169756
Front Vet Sci. 2022 Apr 07;9:820233
pubmed: 35464363
Pathogens. 2021 Oct 18;10(10):
pubmed: 34684293
J Toxicol Environ Health. 1996 May;48(1):1-34
pubmed: 8637056
Vet Microbiol. 2020 May;244:108655
pubmed: 32402335
Annu Rev Anim Biosci. 2016;4:129-54
pubmed: 26646630
Vet Res. 2016 Jan 11;47:17
pubmed: 26754154
Toxins (Basel). 2019 Nov 05;11(11):
pubmed: 31694331
Toxins (Basel). 2010 Jun;2(6):1300-17
pubmed: 22069639
J Biol Chem. 1999 May 14;274(20):13985-92
pubmed: 10318810
Porcine Health Manag. 2021 Jan 4;7(1):3
pubmed: 33397503
Toxicol Lett. 2008 Apr 1;177(3):215-22
pubmed: 18329193
Porcine Health Manag. 2022 Mar 20;8(1):13
pubmed: 35307023
Clin Vaccine Immunol. 2013 Oct;20(10):1604-16
pubmed: 23966552
Nature. 2014 Sep 25;513(7519):517-22
pubmed: 25209664
Vaccine. 2015 Jul 31;33(32):3881-6
pubmed: 26117152
Nat Rev Immunol. 2008 Apr;8(4):247-58
pubmed: 18323851
Toxins (Basel). 2021 Feb 23;13(2):
pubmed: 33672250
Zentralbl Veterinarmed A. 1997 Dec;44(9-10):539-50
pubmed: 9465774
Anim Nutr. 2016 Jun;2(2):63-68
pubmed: 29767037
Food Chem Toxicol. 2015 Jun;80:7-16
pubmed: 25701311
Arch Toxicol. 2016 Dec;90(12):2931-2957
pubmed: 27663890
Vaccine. 2009 Jun 8;27(28):3788-99
pubmed: 19442420
Arch Toxicol. 2010 Sep;84(9):663-79
pubmed: 20798930
J Agric Food Chem. 2017 Aug 23;65(33):7052-7070
pubmed: 27599910
Vet Microbiol. 2014 Dec 5;174(3-4):419-426
pubmed: 25465662
Toxicol Sci. 2002 Oct;69(2):373-82
pubmed: 12377986
Mycotoxin Res. 2013 Aug;29(3):185-92
pubmed: 23436220
Vet Res. 2020 May 13;51(1):66
pubmed: 32404209
Prev Vet Med. 2017 Jul 1;142:16-29
pubmed: 28606362
Porcine Health Manag. 2016 Nov 1;2:28
pubmed: 28405454
Vaccines (Basel). 2022 Jun 11;10(6):
pubmed: 35746542
Front Immunol. 2020 Aug 13;11:2009
pubmed: 32903433
Res Vet Sci. 2015 Dec;103:96-102
pubmed: 26679802
J Virol. 2022 Feb 9;96(3):e0114021
pubmed: 34851149
EFSA J. 2017 Sep 11;15(9):e04718
pubmed: 32625635
Vet Res. 2015 May 14;46:52
pubmed: 25971313
Toxins (Basel). 2019 Jun 27;11(7):
pubmed: 31252650
J Vet Diagn Invest. 1992 Apr;4(2):127-33
pubmed: 1616976
Toxins (Basel). 2020 Mar 18;12(3):
pubmed: 32197345