Epidemiology, microbiology, and outcomes of infective endocarditis in a tertiary center in Jordan.
Bacteria
Clinical features
Human
Treatment
Valvular disease
Journal
Wiener medizinische Wochenschrift (1946)
ISSN: 1563-258X
Titre abrégé: Wien Med Wochenschr
Pays: Austria
ID NLM: 8708475
Informations de publication
Date de publication:
13 Feb 2023
13 Feb 2023
Historique:
received:
20
06
2022
accepted:
10
01
2023
entrez:
13
2
2023
pubmed:
14
2
2023
medline:
14
2
2023
Statut:
aheadofprint
Résumé
Infective endocarditis (IE) is a relatively rare but serious and life-threatening disease with substantial mortality and morbidity despite progress in diagnostic and treatment techniques. The aim of this study is to investigate the epidemiology, clinical characteristics, microbiological profile, and outcomes of IE patients in a tertiary care facility in Jordan, the Jordan University Hospital (JUH). This is a retrospective case series study which was conducted at JUH. A total of 23 patients with either definite or possible IE according to the Modified Duke Criteria were included in the study. Medical records were reviewed, and relevant information was collected. Descriptive data analysis was performed. Our study identified a total of 23 patients with infective endocarditis; 65.2% were males, with a mean age of 40.4 years. The majority of patients had an underlying cardiac disease (60.9%), with the most common being congenital heart diseases (17.4%). The most commonly affected valves were the left-side heart valves, with the mitral valve (52.2%) being the most common followed by the aortic valve (34.8%). The most common organism detected in blood culture was Streptococcus viridans (21.7%) followed by methicillin-resistant Staphylococcus aureus. The most common complications among the patients were heart failure and septic shock, and the mortality rate among the patients was 13%. In patients with endocarditis, Streptococcus viridans is the most common culture-positive bacteria at JUH. One third of our patients needed surgical intervention and the mortality rate was 13%.
Sections du résumé
BACKGROUND
BACKGROUND
Infective endocarditis (IE) is a relatively rare but serious and life-threatening disease with substantial mortality and morbidity despite progress in diagnostic and treatment techniques. The aim of this study is to investigate the epidemiology, clinical characteristics, microbiological profile, and outcomes of IE patients in a tertiary care facility in Jordan, the Jordan University Hospital (JUH).
METHODS
METHODS
This is a retrospective case series study which was conducted at JUH. A total of 23 patients with either definite or possible IE according to the Modified Duke Criteria were included in the study. Medical records were reviewed, and relevant information was collected. Descriptive data analysis was performed.
RESULTS
RESULTS
Our study identified a total of 23 patients with infective endocarditis; 65.2% were males, with a mean age of 40.4 years. The majority of patients had an underlying cardiac disease (60.9%), with the most common being congenital heart diseases (17.4%). The most commonly affected valves were the left-side heart valves, with the mitral valve (52.2%) being the most common followed by the aortic valve (34.8%). The most common organism detected in blood culture was Streptococcus viridans (21.7%) followed by methicillin-resistant Staphylococcus aureus. The most common complications among the patients were heart failure and septic shock, and the mortality rate among the patients was 13%.
CONCLUSION
CONCLUSIONS
In patients with endocarditis, Streptococcus viridans is the most common culture-positive bacteria at JUH. One third of our patients needed surgical intervention and the mortality rate was 13%.
Identifiants
pubmed: 36781611
doi: 10.1007/s10354-023-01004-w
pii: 10.1007/s10354-023-01004-w
pmc: PMC9924832
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, ein Teil von Springer Nature.
Références
Int Sch Res Notices. 2014 Nov 04;2014:340601
pubmed: 27355045
J Infect Public Health. 2014 Sep-Oct;7(5):400-6
pubmed: 24932716
Am Heart J. 2015 Oct;170(4):830-6
pubmed: 26386808
Clin Infect Dis. 2005 Aug 15;41(4):507-14
pubmed: 16028160
Nat Rev Dis Primers. 2016 Sep 01;2:16059
pubmed: 27582414
Mediators Inflamm. 2017;2017:7962546
pubmed: 28659664
PLoS One. 2013 Dec 09;8(12):e82665
pubmed: 24349331
JAMA. 2002 Jul 3;288(1):75-81
pubmed: 12090865
Glob Heart. 2014 Mar;9(1):131-43
pubmed: 25432123
N Engl J Med. 2012 Jun 28;366(26):2466-73
pubmed: 22738096
Turk Kardiyol Dern Ars. 2010 Mar;38(2):107-11
pubmed: 20473012
Heart. 2006 Jul;92(7):879-85
pubmed: 16216860
Eur Heart J. 2015 Nov 21;36(44):3075-3128
pubmed: 26320109
Int J Infect Dis. 2007 Sep;11(5):430-3
pubmed: 17331773
J Epidemiol Glob Health. 2021 Dec;11(4):435-443
pubmed: 34735715
Mayo Clin Proc. 2020 May;95(5):982-997
pubmed: 32299668
J Saudi Heart Assoc. 2011 Oct;23(4):207-11
pubmed: 23960650
Ann Saudi Med. 2009 Nov-Dec;29(6):433-6
pubmed: 19847079
Qatar Med J. 2020 Sep 28;2020(2):24
pubmed: 33282709
Mater Med Pol. 1990 Jul-Sep;22(3):173-5
pubmed: 2132422
J Infect Public Health. 2017 Nov - Dec;10(6):734-739
pubmed: 28185820
East Mediterr Health J. 2007 Jan-Feb;13(1):64-71
pubmed: 17546907
Curr Probl Cardiol. 2007 Nov;32(11):609-61
pubmed: 17976510
Clin Infect Dis. 2000 Apr;30(4):633-8
pubmed: 10770721
Arch Intern Med. 2009 Mar 9;169(5):463-73
pubmed: 19273776
Data Brief. 2020 Nov 01;33:106478
pubmed: 33225027
Eur Heart J. 2011 Aug;32(16):2027-33
pubmed: 19329497
J Infect. 2002 Oct;45(3):152-9
pubmed: 12387770
Heart. 2000 Jul;84(1):25-30
pubmed: 10862581
Cytokine. 2015 Jan;71(1):16-21
pubmed: 25213166
J Intensive Care Med. 2016 Mar;31(3):151-63
pubmed: 25320158
JAMA. 2017 Apr 25;317(16):1652-1660
pubmed: 28444279
Chest. 2007 Sep;132(3):1025-35
pubmed: 17873196
Clin Infect Dis. 2010 Jul 15;51(2):131-40
pubmed: 20540619
Circulation. 2017 Jun 20;135(25):e1159-e1195
pubmed: 28298458
SAGE Open Med. 2017 Nov 13;5:2050312117741772
pubmed: 29163950
Nat Clin Pract Cardiovasc Med. 2006 Jun;3(6):310-7
pubmed: 16729009
Eur J Cardiothorac Surg. 2018 Dec 1;54(6):1060-1066
pubmed: 29873701
BMJ Open. 2021 Mar 16;11(3):e045343
pubmed: 33727273
J Am Coll Cardiol. 2015 May 19;65(19):2070-6
pubmed: 25975469