Hierarchically Injectable Hydrogel Sequentially Delivers AntagomiR-467a-3p-Loaded and AntagomiR-874-5p-Loaded Satellite-Cell-Targeting Bioengineered Extracellular Vesicles Attenuating Sarcopenia.
extracellular vesicles
microRNA
myogenesis
sarcopenia
stemness
Journal
Advanced healthcare materials
ISSN: 2192-2659
Titre abrégé: Adv Healthc Mater
Pays: Germany
ID NLM: 101581613
Informations de publication
Date de publication:
07 2023
07 2023
Historique:
revised:
06
02
2023
received:
24
11
2022
medline:
7
7
2023
pubmed:
15
2
2023
entrez:
14
2
2023
Statut:
ppublish
Résumé
Sarcopenia is a geriatric disease characterized by reduced muscle function and mass. The capacity to self-renew and myogenesis of satellite cells (SCs) declines with age, resulting in age-related sarcopenia. MicroRNAs (miRNAs) can regulate the proliferation and myogenesis of SCs. In this study, it is identified that miR-467a-3p and miR-874-5p could respectively mediate the stemness and myogenesis of SCs by performing bioinformatics analysis. AntagomiR-467a-3p (ant-467a) and antagomiR-874-5p (ant-874) improve the stemness and myogenesis of SCs, respectively. SC-targeting extracellular vesicles (EVs) are constructed by overexpressing TSG101 on the surface of EVs isolated from bone marrow mesenchymal stem cells. Ant-467a loaded EVs (EVs-467a) and ant-874 loaded EVs (EVs-874) are prepared by transferring ant-467a and ant-874 into SC-targeting EVs. EVs-467a and EVs-874 are more effective than ant-467a and ant-874 in promoting the stemness and myogenesis of SCs. Sequentially intermuscular injection of EVs-467a and EVs-874 significantly improve sarcopenia in ovariectomy mice. The effects of multiple injections of EVs-467a and EVs-874 in the treatment of sarcopenia could be achieved by using a hierarchically injectable hydrogel to sustainedly release EVs-467a and EVs-874 in vivo. The findings provide an EV-based SC-targeting antagomiRNAs controlled release strategy as a novel therapy against sarcopenia.
Identifiants
pubmed: 36782053
doi: 10.1002/adhm.202203056
doi:
Substances chimiques
Antagomirs
0
Hydrogels
0
MicroRNAs
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2203056Informations de copyright
© 2023 The Authors. Advanced Healthcare Materials published by Wiley-VCH GmbH.
Références
I. Janssen, S. B. Heymsfield, Z. M. Wang, R. Ross, J. Appl. Physiol. 2000, 89, 81.
A. J. Cruz-Jentoft, J. P. Baeyens, J. M. Bauer, Y. Boirie, T. Cederholm, F. Landi, F. C. Martin, J.-P. Michel, Y. Rolland, S. M. Schneider, E. Topinková, M. Vandewoude, M. Zamboni, Age Ageing 2010, 39, 412.
P. Kwan, Mech. Ageing Dev. 2013, 134, 349.
A. J. Cruz-Jentoft, A. A. Sayer, Lancet 2019, 393, 2636.
A. MAURO, J. Biophys. Biochem. Cytol. 1961, 9, 493.
H. Dai, W. Zheng, J. Luo, G. Yu, C. Song, Y. Wu, J. Xu, J. Orthop. Transl. 2022, 35, 23.
K. Day, G. Shefer, A. Shearer, Z. Yablonka-Reuveni, Dev. Biol. 2010, 340, 330.
P. Lorenzon, E. Bandi, F. de Guarrini, T. Pietrangelo, R. Schäfer, M. Zweyer, A. Wernig, F. Ruzzier, Exp. Gerontol. 2004, 39, 1545.
M. E. Carlson, I. M. Conboy, Aging Cell 2007, 6, 371.
D. W. van Pelt, I. J. Vechetti, M. M. Lawrence, K. L. van Pelt, P. Patel, B. F. Miller, T. A. Butterfield, E. E. Dupont-Versteegden, Am. J. Physiol.: Cell Physiol. 2020, 319, C419.
a) Y. Wei, X. Tao, H. Xu, Y. Chen, L. Zhu, G. Tang, M. Li, A. Jiang, S. Shuai, J. Ma, L. Jin, A. Wen, Q. Wang, G. Zhu, M. Xie, J. Wu, T. He, Y. Jiang, X. Li, Yichuan 2016, 592, 60;
b) A. Soriano-Arroquia, L. House, L. Tregilgas, E. Canty-Laird, K. Goljanek-Whysall, Biogerontology 2016, 17, 641.
S.-Z. Han, K. Gao, S.-Y. Chang, H.-M. Choe, H.-J. Paek, B.-H. Quan, X.-Y. Liu, L.-H. Yang, S.-T. Lv, X.-J. Yin, L.-H. Quan, J.-D. Kang, J. Agric. Food Chem. 2022, 70, 10121.
L. Li, A. L. Sarver, S. Alamgir, S. Subramanian, Lab. Invest. 2012, 92, 571.
C. Hadjimichael, C. Nikolaou, J. Papamatheakis, A. Kretsovali, Stem Cell Rep. 2016, 6, 292.
a) Y. Tay, J. Zhang, A. M. Thomson, B. Lim, I. Rigoutsos, Nature 2008, 455, 1124;
b) N. Xu, T. Papagiannakopoulos, G. Pan, J. A. Thomson, K. S. Kosik, Cell 2009, 137, 647.
X. Wang, C. P. Hodgkinson, K. Lu, A. J. Payne, R. E. Pratt, V. J. Dzau, Sci. Rep. 2016, 6, 23017.
R. L. Judson, J. E. Babiarz, M. Venere, R. Blelloch, Nat. Biotechnol. 2009, 27, 459.
O. M. Elsharkasy, J. Z. Nordin, D. W. Hagey, O. G. de Jong, R. M. Schiffelers, S. E. Andaloussi, P. Vader, Adv. Drug Delivery Rev. 2020, 159, 332.
N. Perets, O. Betzer, R. Shapira, S. Brenstein, A. Angel, T. Sadan, U. Ashery, R. Popovtzer, D. Offen, Nano Lett. 2019, 19, 3422.
a) S. Kamerkar, V. S. LeBleu, H. Sugimoto, S. Yang, C. F. Ruivo, S. A. Melo, J. J. Lee, R. Kalluri, Nature 2017, 546, 498;
b) W. Nie, G. Wu, J. Zhang, L.-L. Huang, J. Ding, A. Jiang, Y. Zhang, Y. Liu, J. Li, K. Pu, H.-Y. Xie, Angew. Chem., Int. Ed. Engl. 2020, 59, 2018.
Y. Hu, X. Li, Q. Zhang, Z. Gu, Y. Luo, J. Guo, X. Wang, Y. Jing, X. Chen, J. Su, Bioact. Mater. 2021, 6, 2905.
Y. Cui, Y. Guo, L. Kong, J. Shi, P. Liu, R. Li, Y. Geng, W. Gao, Z. Zhang, D. Fu, Bioact. Mater. 2022, 10, 207.
T. Imai, Y. Takahashi, M. Nishikawa, K. Kato, M. Morishita, T. Yamashita, A. Matsumoto, C. Charoenviriyakul, Y. Takakura, J. Extracell. Vesicles 2015, 4, 26238.
K. Zhang, X. Zhao, X. Chen, Y. Wei, W. Du, Y. Wang, L. Liu, W. Zhao, Z. Han, D. Kong, Q. Zhao, Z. Guo, Z. Han, N. Liu, F. Ma, Z. Li, ACS Appl. Mater. Interfaces 2018, 10, 30081.
D. Zhu, Z. Li, K. Huang, T. G. Caranasos, J. S. Rossi, K. Cheng, Nat. Commun. 2021, 12, 1412.
G. Cheng, D. Zhu, K. Huang, T. G. Caranasos, J. Mol. Cell. Cardiol. 2022, 169, 113.
M. Monguió-Tortajada, C. Prat-Vidal, D. Martínez-Falguera, A. Teis, C. Soler-Botija, Y. Courageux, M. Munizaga-Larroudé, M. Moron-Font, A. Bayes-Genis, F. E. Borràs, S. Roura, C. Gálvez-Montón, Theranostics 2022, 12, 4656.
L. García-Prat, M. Martínez-Vicente, E. Perdiguero, L. Ortet, J. Rodríguez-Ubreva, E. Rebollo, V. Ruiz-Bonilla, S. Gutarra, E. Ballestar, A. L. Serrano, M. Sandri, P. Muñoz-Cánoves, Nature 2016, 529, 37.
P. Abreu, A. J. Kowaltowski, J. Cachexia Sarcopenia Muscle 2020, 11, 1661.
L. Zhang, Z. Xue, J. Yan, J. Wang, Q. Liu, H. Jiang, Cell Proliferation 2019, 52, e12573.
B. Xia, M. Lin, W. Dong, H. Chen, B. Li, X. Zhang, Y. Hou, G. Lou, J. Biochem. Mol. Toxicol. 2018, 32, e22168.
L. Zhang, C. Ma, X. Wang, J. Bai, S. He, J. Zhang, W. Xin, Y. Li, Y. Jiang, J. Li, D. Zhu, Eur. J. Pharmacol. 2020, 888, 173485.
Z.-W. Luo, F.-X.-Z. Li, Y.-W. Liu, S.-S. Rao, H. Yin, J. Huang, C.-Y. Chen, Y. Hu, Y. Zhang, Y.-J. Tan, L.-Q. Yuan, T.-H. Chen, H.-M. Liu, J. Cao, Z.-Z. Liu, Z.-X. Wang, H. Xie, Nanoscale 2019, 11, 20884.
Y. Wang, J. Yao, L. Cai, T. Liu, X. Wang, Y. Zhang, Z. Zhou, T. Li, M. Liu, R. Lai, X. Liu, Int. J. Nanomed. 2020, 15, 7967.
J. Jin, F. Qian, D. Zheng, W. He, J. Gong, Q. He, Int. J. Nanomed. 2021, 16, 3565.
Q. Yuan, X. Wang, L. Liu, Y. Cai, X. Zhao, H. Ma, Y. Zhang, Stem Cells Dev. 2020, 29, 1038.
J. Wang, Q. Jiang, O. D. Faleti, C.-M. Tsang, M. Zhao, G. Wu, S.-W. Tsao, M. Fu, Y. Chen, T. Ding, T. Chong, Y. Long, X. Yang, Y. Zhang, Y. Cai, H. Li, M. Peng, X. Lyu, X. Li, Mol. Ther.-Nucleic Acids 2020, 22, 153.
X. Wang, H. Zhang, M. Bai, T. Ning, S. Ge, T. Deng, R. Liu, L. Zhang, G. Ying, Y. Ba, Mol. Ther. 2018, 26, 774.
A. Stamatikos, E. Knight, L. Vojtech, L. Bi, B. K. Wacker, C. Tang, D. A. Dichek, Hum. Gene Ther. 2020, 31, 219.
S. Shafei, M. Khanmohammadi, R. Heidari, H. Ghanbari, V. T. Nooshabadi, S. Farzamfar, M. Akbariqomi, N. S. Sanikhani, M. Absalan, G. Tavoosidana, J. Biomed. Mater. Res., Part A 2020, 108, 545.
Y. Zhang, Z. Cai, Y. Shen, Q. Lu, W. Gao, X. Zhong, K. Yao, J. Yuan, H. Liu, J. Nanobiotechnol. 2021, 19, 271.
B. Li, J. Yang, R. Wang, J. Li, X. Li, X. Zhou, S. Qiu, R. Weng, Z. Wu, C. Tang, P. Li, Ann. Transl. Med. 2020, 8, 1498.
J. Gan, L. Sun, G. Chen, W. Ma, Y. Zhao, L. Sun, Adv. Healthcare Mater. 2022, 89, 2201105.
S. Yang, B. Zhu, P. Yin, L. Zhao, Y. Wang, Z. Fu, R. Dang, J. Xu, J. Zhang, N. Wen, ACS Biomater. Sci. Eng. 2020, 6, 1590.
a) Y. Zhou, X.-L. Zhang, S.-T. Lu, N.-Y. Zhang, H.-J. Zhang, J. Zhang, J. Zhang, Stem Cell Res. Ther. 2022, 13, 407;
b) J. Yang, Z. Chen, D. Pan, H. Li, J. Shen, Int. J. Nanomed. 2020, 15, 5911;
c) D. Su, H.-I. Tsai, Z. Xu, F. Yan, Y. Wu, Y. Xiao, X. Liu, Y. Wu, S. Parvanian, W. Zhu, J. E. Eriksson, D. Wang, H. Zhu, H. Chen, F. Cheng, J. Extracell. Vesicles 2019, 9, 1709262.
A. Musarò, S. Carosio, Methods Mol. Biol. 2017, 1553, 155.
W. Guo, K. V. Spiller, J. Tang, C. M. Karner, M. J. Hilton, C. Wu, Stem Cell Res. 2021, 53, 102317.
S. Tyanova, T. Temu, J. Cox, Nat. Protoc. 2016, 11, 2301.