Molecular pathways that drive diabetic kidney disease.
Journal
The Journal of clinical investigation
ISSN: 1558-8238
Titre abrégé: J Clin Invest
Pays: United States
ID NLM: 7802877
Informations de publication
Date de publication:
15 02 2023
15 02 2023
Historique:
pubmed:
15
2
2023
medline:
17
2
2023
entrez:
14
2
2023
Statut:
epublish
Résumé
Kidney disease is a major driver of mortality among patients with diabetes and diabetic kidney disease (DKD) is responsible for close to half of all chronic kidney disease cases. DKD usually develops in a genetically susceptible individual as a result of poor metabolic (glycemic) control. Molecular and genetic studies indicate the key role of podocytes and endothelial cells in driving albuminuria and early kidney disease in diabetes. Proximal tubule changes show a strong association with the glomerular filtration rate. Hyperglycemia represents a key cellular stress in the kidney by altering cellular metabolism in endothelial cells and podocytes and by imposing an excess workload requiring energy and oxygen for proximal tubule cells. Changes in metabolism induce early adaptive cellular hypertrophy and reorganization of the actin cytoskeleton. Later, mitochondrial defects contribute to increased oxidative stress and activation of inflammatory pathways, causing progressive kidney function decline and fibrosis. Blockade of the renin-angiotensin system or the sodium-glucose cotransporter is associated with cellular protection and slowing kidney function decline. Newly identified molecular pathways could provide the basis for the development of much-needed novel therapeutics.
Identifiants
pubmed: 36787250
pii: 165654
doi: 10.1172/JCI165654
pmc: PMC9927939
doi:
pii:
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDDK NIH HHS
ID : P50 DK064236
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK087635
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK132630
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK076077
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK105821
Pays : United States
Références
Am J Kidney Dis. 2021 Apr;77(4 Suppl 1):A7-A8
pubmed: 33752804
Am J Pathol. 2010 Sep;177(3):1065-71
pubmed: 20651248
Nat Commun. 2018 Jun 1;9(1):2143
pubmed: 29858571
JAMA. 2015 Sep 1;314(9):884-94
pubmed: 26325557
J Am Soc Nephrol. 2012 Aug;23(8):1339-50
pubmed: 22797190
Am J Physiol Renal Physiol. 2008 May;294(5):F1185-94
pubmed: 18287402
Kidney Int Rep. 2021 Feb 03;6(4):1066-1080
pubmed: 33912757
Nat Genet. 2020 Feb;52(2):167-176
pubmed: 31959995
PLoS Genet. 2012 Sep;8(9):e1002921
pubmed: 23028342
Front Med (Lausanne). 2017 Jul 12;4:102
pubmed: 28748185
N Engl J Med. 2005 Dec 22;353(25):2643-53
pubmed: 16371630
Nat Commun. 2021 Apr 13;12(1):2190
pubmed: 33850129
Diabetologia. 1999 Nov;42(11):1341-4
pubmed: 10550418
J Clin Invest. 2011 Jun;121(6):2197-209
pubmed: 21606591
N Engl J Med. 2020 Oct 8;383(15):1436-1446
pubmed: 32970396
Nature. 2021 Jan;589(7841):281-286
pubmed: 33176333
J Am Soc Nephrol. 2019 Oct;30(10):2000-2016
pubmed: 31537649
Nat Commun. 2017 Sep 4;8(1):413
pubmed: 28871079
N Engl J Med. 1989 May 4;320(18):1161-5
pubmed: 2710189
Nat Commun. 2022 Jul 11;13(1):4018
pubmed: 35821371
Semin Nephrol. 2012 Jul;32(4):350-6
pubmed: 22958489
Kidney360. 2021 Feb 26;2(4):755-762
pubmed: 35373048
Br J Pharmacol. 2005 Jun;145(3):323-33
pubmed: 15765100
N Engl J Med. 1993 Sep 30;329(14):1035-6
pubmed: 8366905
DNA Cell Biol. 2009 Nov;28(11):543-53
pubmed: 19754268
Nat Med. 2018 Nov;24(11):1721-1731
pubmed: 30275566
Nat Med. 2015 Jan;21(1):37-46
pubmed: 25419705
J Am Soc Nephrol. 2021 Sep;32(9):2352-2361
pubmed: 34272327
J Am Soc Nephrol. 2017 Feb;28(2):557-574
pubmed: 27647854
Nephron. 2019;143(1):38-42
pubmed: 30947190
Nat Commun. 2019 Jun 5;10(1):2461
pubmed: 31165727
J Am Soc Nephrol. 2014 May;25(5):1050-62
pubmed: 24722437
Am J Physiol. 1998 Jul;275(1):F8-17
pubmed: 9688999
Diabetes. 2014 May;63(5):1748-62
pubmed: 24458354
Immunity. 2021 Nov 9;54(11):2632-2649.e6
pubmed: 34715018
Cell Res. 2019 May;29(5):347-364
pubmed: 30948788
Circulation. 2009 Jan 20;119(2):351-7
pubmed: 19095622
Adv Chronic Kidney Dis. 2014 May;21(3):281-6
pubmed: 24780456
Nat Genet. 2022 Jul;54(7):950-962
pubmed: 35710981
Cell Metab. 2020 Sep 1;32(3):404-419.e6
pubmed: 32726607
J Clin Invest. 2011 Jun;121(6):2181-96
pubmed: 21606597
Diabetes. 2017 Mar;66(3):763-778
pubmed: 27899487
Cell Death Differ. 2013 Jan;20(1):31-42
pubmed: 22743996
Proc Natl Acad Sci U S A. 2020 Nov 17;117(46):29013-29024
pubmed: 33144501
J Am Soc Nephrol. 2011 Oct;22(10):1863-75
pubmed: 21868496
Kidney Int. 2019 Oct;96(4):957-970
pubmed: 31402170
Kidney Int. 2018 Aug;94(2):326-345
pubmed: 29861058
J Am Soc Nephrol. 2019 Apr;30(4):546-562
pubmed: 30858225
Am J Kidney Dis. 2012 Aug;60(2):197-206
pubmed: 22464876
JCI Insight. 2017 Jul 20;2(14):
pubmed: 28724797
Hypertension. 2017 May;69(5):870-878
pubmed: 28320854
J Clin Invest. 2016 Nov 1;126(11):4072-4075
pubmed: 27760046
N Engl J Med. 2006 Jan 12;354(2):131-40
pubmed: 16407508
Kidney Int. 2008 Jul;74(1):22-36
pubmed: 18418356
J Am Soc Nephrol. 2018 Jan;29(1):81-91
pubmed: 28993506
Nat Immunol. 2022 Jun;23(6):947-959
pubmed: 35552540
Commun Biol. 2022 Jun 13;5(1):580
pubmed: 35697829
N Engl J Med. 2008 Mar 13;358(11):1129-36
pubmed: 18337603
Metabolism. 2021 Nov;124:154890
pubmed: 34560098
Am J Physiol Cell Physiol. 2005 Oct;289(4):C959-70
pubmed: 15930146
Kidney Int. 2005 Jan;67(1):157-66
pubmed: 15610239
Kidney Int. 2018 Jun;93(6):1330-1343
pubmed: 29477240
Kidney Int. 2014 May;85(5):1214-24
pubmed: 24429397
Kidney Int. 2022 Mar;101(3):510-526
pubmed: 34856312
Front Endocrinol (Lausanne). 2020 Jun 19;11:359
pubmed: 32655493
Kidney Int. 2005 Oct;68(4):1648-59
pubmed: 16164642
Semin Nephrol. 2020 Mar;40(2):199-205
pubmed: 32303282
Am J Pathol. 2001 Aug;159(2):599-608
pubmed: 11485918
Metabolomics. 2020 Jan 10;16(1):11
pubmed: 31925564
Pathology. 2017 Apr;49(3):247-258
pubmed: 28291548
N Engl J Med. 2019 Jun 13;380(24):2295-2306
pubmed: 30990260
Kidney Int. 2020 Nov;98(5):1079-1081
pubmed: 33126968
Nephron Exp Nephrol. 2009;111(4):e73-9
pubmed: 19293596
Trends Cell Biol. 2022 Oct;32(10):841-853
pubmed: 35473814
Nat Med. 2017 Jun;23(6):753-762
pubmed: 28436957
Cell Res. 2021 Feb;31(2):107-125
pubmed: 33268902
J Am Soc Nephrol. 2021 Nov;32(11):2863-2876
pubmed: 34348909
Kidney Int. 2009 Jul;76(2):145-8
pubmed: 19404275
Semin Nephrol. 2012 Jul;32(4):319-26
pubmed: 22958486
Proc Natl Acad Sci U S A. 2016 May 24;113(21):E3002-11
pubmed: 27162351
Circulation. 2020 Jun 2;141(22):1800-1812
pubmed: 32479196
Kidney Int. 2017 Jul;92(1):140-153
pubmed: 28318634
Nat Rev Nephrol. 2020 Apr;16(4):206-222
pubmed: 31942046
Pediatr Nephrol. 2016 Jul;31(7):1047-54
pubmed: 26490951
Lancet Diabetes Endocrinol. 2020 Apr;8(4):301-312
pubmed: 32135136
Am J Physiol. 1988 Mar;254(3 Pt 2):F407-16
pubmed: 3348418
Nat Cell Biol. 2018 Sep;20(9):1013-1022
pubmed: 30154567
Diabetes. 2006 Jan;55(1):225-33
pubmed: 16380497
Am J Physiol Renal Physiol. 2002 Apr;282(4):F585-91
pubmed: 11880318
Nat Commun. 2022 Sep 6;13(1):5253
pubmed: 36068241
Nat Rev Dis Primers. 2015 Jul 30;1:15018
pubmed: 27188921
Diabetologia. 2018 Oct;61(10):2098-2107
pubmed: 30132034
Kidney Int. 2022 Oct;102(4):766-779
pubmed: 35779608
Nat Genet. 2021 Sep;53(9):1322-1333
pubmed: 34385711
J Am Soc Nephrol. 2009 Dec;20(12):2503-12
pubmed: 19729434
Cell Rep. 2019 Oct 29;29(5):1261-1273.e6
pubmed: 31665638
Cell Metab. 2022 Jul 5;34(7):1064-1078.e6
pubmed: 35709763
J Clin Invest. 2019 Jul 22;129(8):3387-3400
pubmed: 31329164
Cell Signal. 2010 Nov;22(11):1615-25
pubmed: 20466059
J Am Soc Nephrol. 2011 Oct;22(10):1846-55
pubmed: 21921143
Kidney Int. 2011 Jun;79(12):1312-21
pubmed: 21389970
J Clin Invest. 2018 Jan 2;128(1):483-499
pubmed: 29227285
Sci Rep. 2020 Jun 22;10(1):10018
pubmed: 32572055
Sci Signal. 2017 Apr 11;10(474):
pubmed: 28400537
J Am Soc Nephrol. 2013 Feb;24(2):268-82
pubmed: 23334396
Am J Hum Genet. 2017 Jun 1;100(6):940-953
pubmed: 28575649
J Am Soc Nephrol. 2015 Feb;26(2):258-69
pubmed: 25060060
N Engl J Med. 2020 Dec 03;383(23):2219-2229
pubmed: 33264825
Kidney Int. 1998 Dec;54(6):1872-8
pubmed: 9853252
Nat Rev Nephrol. 2017 Apr;13(4):213-225
pubmed: 28163307
J Clin Invest. 2019 May 7;129(7):2807-2823
pubmed: 31063459
J Am Soc Nephrol. 2018 Apr;29(4):1223-1237
pubmed: 29440279
Genome Res. 2008 Mar;18(3):404-11
pubmed: 18230805
Am J Physiol Renal Physiol. 2013 Mar 1;304(5):F614-22
pubmed: 23283998
Am J Pathol. 2011 May;178(5):2205-14
pubmed: 21514434
Nephrol Dial Transplant. 2015 Oct;30(10):1706-11
pubmed: 26050268
N Engl J Med. 2021 Dec 9;385(24):2252-2263
pubmed: 34449181
J Clin Invest. 2010 Apr;120(4):1056-68
pubmed: 20335659
Kidney Int. 2018 Jun;93(6):1417-1431
pubmed: 29709239
Clin Sci (Lond). 2022 Jan 28;136(2):167-180
pubmed: 35048962
Clin Nephrol. 2019 Jul;92(1):25-35
pubmed: 31079598
Cell Metab. 2012 Feb 8;15(2):186-200
pubmed: 22326220
Cell Rep. 2019 Apr 30;27(5):1551-1566.e5
pubmed: 31042480
Nat Rev Nephrol. 2020 Jun;16(6):317-336
pubmed: 32152499
Am J Physiol Renal Physiol. 2020 Jan 1;318(1):F248-F259
pubmed: 31790302
Nat Commun. 2021 Aug 23;12(1):5078
pubmed: 34426578
Nat Rev Immunol. 2022 Jul 25;:
pubmed: 35879417
PLoS One. 2013;8(1):e55027
pubmed: 23359116
Diabetes. 2012 Jan;61(1):208-16
pubmed: 22106160
PLoS One. 2018 Apr 23;13(4):e0195172
pubmed: 29684044
Cell Metab. 2019 Oct 1;30(4):784-799.e5
pubmed: 31474566
J Diabetes Res. 2017;2017:7242384
pubmed: 28695133
Lancet. 2019 May 11;393(10184):1937-1947
pubmed: 30995972
Cell Death Dis. 2020 Nov 20;11(11):994
pubmed: 33219209
Diabetologia. 2022 Jan;65(1):140-149
pubmed: 34686904
J Am Soc Nephrol. 2010 Apr;21(4):556-63
pubmed: 20167701
Nat Med. 2019 May;25(5):805-813
pubmed: 31011203
Cell Metab. 2021 Feb 2;33(2):379-394.e8
pubmed: 33301705
Semin Nephrol. 2018 Mar;38(2):121-126
pubmed: 29602395
Lancet Diabetes Endocrinol. 2021 Oct;9(10):653-662
pubmed: 34425083
JCI Insight. 2019 Jun 6;4(11):
pubmed: 31167971
J Am Soc Nephrol. 2016 Dec;27(12):3653-3665
pubmed: 27032892
Nat Metab. 2020 Aug;2(8):732-743
pubmed: 32694833
Am J Pathol. 1995 May;146(5):1065-72
pubmed: 7747801
Nat Commun. 2017 Nov 3;8(1):1286
pubmed: 29097680
JCI Insight. 2021 Oct 8;6(19):
pubmed: 34473647
AAPS J. 2019 Dec 5;22(1):8
pubmed: 31807911
J Clin Invest. 2016 Nov 1;126(11):4205-4218
pubmed: 27760051
Diabetes Care. 2022 Dec 1;45(12):3075-3090
pubmed: 36189689
Kidney Int Rep. 2018 Sep 18;4(1):94-102
pubmed: 30596172
Nat Med. 2008 Mar;14(3):290-8
pubmed: 18311147
Diabetes. 2018 Jul;67(7):1414-1427
pubmed: 29703844
Nat Commun. 2021 Apr 15;12(1):2277
pubmed: 33859189
J Clin Invest. 2021 Mar 1;131(5):
pubmed: 33465052
N Engl J Med. 2021 Sep 2;385(10):896-907
pubmed: 34215025
J Am Soc Nephrol. 2022 Jan;33(1):225-237
pubmed: 34732509
Nat Metab. 2020 Aug;2(8):744-762
pubmed: 32694834
J Am Soc Nephrol. 2017 Nov;28(11):3312-3322
pubmed: 28751525
Cell Commun Signal. 2020 Jul 8;18(1):105
pubmed: 32641054
J Clin Invest. 2014 Apr;124(4):1608-21
pubmed: 24590287
Nat Commun. 2019 Apr 23;10(1):1835
pubmed: 31015435
Curr Diab Rep. 2019 Aug 30;19(10):91
pubmed: 31471761
J Am Soc Nephrol. 2018 Jul;29(7):1939-1947
pubmed: 29777021
J Am Soc Nephrol. 2017 Apr;28(4):1023-1039
pubmed: 28143897
Annu Rev Physiol. 1985;47:85-101
pubmed: 3888090
Clin J Am Soc Nephrol. 2020 Dec 31;16(1):37-47
pubmed: 33380473
JCI Insight. 2020 Aug 6;5(15):
pubmed: 32614804
JCI Insight. 2019 Nov 1;4(21):
pubmed: 31573977