α-Synuclein Aggregation Inhibitory Procerolides and Diphenylalkanes from the Ascidian

Animals Humans alpha-Synuclein / metabolism Urochordata / metabolism Parkinson Disease / metabolism

Journal

Journal of natural products
ISSN: 1520-6025
Titre abrégé: J Nat Prod
Pays: United States
ID NLM: 7906882

Informations de publication

Date de publication:
24 03 2023
Historique:
pubmed: 15 2 2023
medline: 28 3 2023
entrez: 14 2 2023
Statut: ppublish

Résumé

The aggregation of the neuronal protein α-synuclein (α-syn) is intrinsically linked to the development and progression of Parkinson's disease (PD). Recently we screened the MeOH extracts from 283 marine invertebrates for α-syn binding activity using an affinity mass spectrometry (MS) binding assay and found that the extract of the ascidian

Identifiants

DOI: 10.1021/acs.jnatprod.2c01140 PMID: 36787528
pubmed: 36787528
doi: 10.1021/acs.jnatprod.2c01140
doi:

Substances chimiques

alpha-Synuclein 0
Procera 0
butenolide 8KXK25H388

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

533-540

Auteurs

Dale W Prebble (DW)

School of Environment and Science, Griffith University (Gold Coast campus), Parklands Drive, Southport, QLD 4222, Australia.
Griffith Institute for Drug Discovery, Griffith University (Brisbane Innovation Park), Don Young Road, Nathan, QLD 4111, Australia.

Darren C Holland (DC)

School of Environment and Science, Griffith University (Gold Coast campus), Parklands Drive, Southport, QLD 4222, Australia.
Griffith Institute for Drug Discovery, Griffith University (Brisbane Innovation Park), Don Young Road, Nathan, QLD 4111, Australia.
ORCID: 0000-0002-2498-6084

Joshua B Hayton (JB)

School of Environment and Science, Griffith University (Gold Coast campus), Parklands Drive, Southport, QLD 4222, Australia.
Griffith Institute for Drug Discovery, Griffith University (Brisbane Innovation Park), Don Young Road, Nathan, QLD 4111, Australia.

Francesca Ferretti (F)

School of Environment and Science, Griffith University (Gold Coast campus), Parklands Drive, Southport, QLD 4222, Australia.
Griffith Institute for Drug Discovery, Griffith University (Brisbane Innovation Park), Don Young Road, Nathan, QLD 4111, Australia.

Laurence K Jennings (LK)

School of Environment and Science, Griffith University (Gold Coast campus), Parklands Drive, Southport, QLD 4222, Australia.
Griffith Institute for Drug Discovery, Griffith University (Brisbane Innovation Park), Don Young Road, Nathan, QLD 4111, Australia.
ORCID: 0000-0002-1313-0360

Jack Everson (J)

Institute for Glycomics, Griffith University (Gold Coast campus), Parklands Drive, Southport, QLD 4222, Australia.

Mingming Xu (M)

Griffith Institute for Drug Discovery, Griffith University (Brisbane Innovation Park), Don Young Road, Nathan, QLD 4111, Australia.
ORCID: 0000-0002-8158-2879

Milton J Kiefel (MJ)

Institute for Glycomics, Griffith University (Gold Coast campus), Parklands Drive, Southport, QLD 4222, Australia.
ORCID: 0000-0003-1030-1440

George D Mellick (GD)

School of Environment and Science, Griffith University (Gold Coast campus), Parklands Drive, Southport, QLD 4222, Australia.
Griffith Institute for Drug Discovery, Griffith University (Brisbane Innovation Park), Don Young Road, Nathan, QLD 4111, Australia.
ORCID: 0000-0002-7211-4651

Anthony R Carroll (AR)

School of Environment and Science, Griffith University (Gold Coast campus), Parklands Drive, Southport, QLD 4222, Australia.
Griffith Institute for Drug Discovery, Griffith University (Brisbane Innovation Park), Don Young Road, Nathan, QLD 4111, Australia.
ORCID: 0000-0001-7695-8301

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › α-Synuclein Aggregation Inhibitory...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › α-Synuclein Aggregation Inhibitory...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines associées à la maladie de Parkinson › alpha-Synucléine › α-Synuclein Aggregation Inhibitory...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Chordés invertébrés › Urochordata › α-Synuclein Aggregation Inhibitory...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Maladie de Parkinson › α-Synuclein Aggregation Inhibitory...