A Medicinal Chemistry Perspective on Excitatory Amino Acid Transporter 2 Dysfunction in Neurodegenerative Diseases.
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
23 02 2023
23 02 2023
Historique:
pubmed:
15
2
2023
medline:
25
2
2023
entrez:
14
2
2023
Statut:
ppublish
Résumé
The excitatory amino acid transporter 2 (EAAT2) plays a key role in the clearance and recycling of glutamate - the major excitatory neurotransmitter in the mammalian brain. EAAT2 loss/dysfunction triggers a cascade of neurodegenerative events, comprising glutamatergic excitotoxicity and neuronal death. Nevertheless, our current knowledge regarding EAAT2 in neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and Alzheimer's disease (AD), is restricted to post-mortem analysis of brain tissue and experimental models. Thus, detecting EAAT2 in the living human brain might be crucial to improve diagnosis/therapy for ALS and AD. This perspective article describes the role of EAAT2 in physio/pathological processes and provides a structure-activity relationship of EAAT2-binders, bringing two perspectives: therapy (activators) and diagnosis (molecular imaging tools).
Identifiants
pubmed: 36787643
doi: 10.1021/acs.jmedchem.2c01572
pmc: PMC9969404
doi:
Substances chimiques
Excitatory Amino Acid Transporter 2
0
Glutamic Acid
3KX376GY7L
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2330-2346Subventions
Organisme : Wellcome Trust
ID : WT203148/Z/16/Z
Pays : United Kingdom
Commentaires et corrections
Type : ErratumIn
Références
Nat Commun. 2022 Jun 9;13(1):3329
pubmed: 35680945
Eur J Pharmacol. 1999 Dec 15;386(2-3):263-70
pubmed: 10618478
ACS Med Chem Lett. 2022 Sep 19;13(10):1628-1633
pubmed: 36262387
Bioorg Med Chem Lett. 2005 Nov 15;15(22):4985-8
pubmed: 16165356
Exp Brain Res. 2021 Nov;239(11):3277-3287
pubmed: 34463828
J Med Chem. 2018 Sep 13;61(17):7741-7753
pubmed: 30011368
N Engl J Med. 1992 May 28;326(22):1464-8
pubmed: 1349424
Hum Mol Genet. 2010 Aug 1;19(15):3053-67
pubmed: 20494921
J Neuropathol Exp Neurol. 1997 Apr;56(4):440-54
pubmed: 9100675
Alzheimers Dement. 2018 Apr;14(4):535-562
pubmed: 29653606
Front Synaptic Neurosci. 2020 Aug 18;12:37
pubmed: 32973483
J Cell Physiol. 2011 Oct;226(10):2484-93
pubmed: 21792905
J Biol Chem. 2011 Jan 28;286(4):2785-94
pubmed: 21098017
Brain Res Bull. 2010 Mar 16;81(4-5):424-7
pubmed: 19772901
Neuron. 2018 Jun 27;98(6):1080-1098
pubmed: 29953871
Neuroscience. 2006 Feb;137(3):843-51
pubmed: 16297566
Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):4155-60
pubmed: 9108121
J Neurosci. 2017 Jun 21;37(25):6132-6148
pubmed: 28559377
J Med Chem. 2014 Feb 13;57(3):1023-32
pubmed: 24456310
Q J Nucl Med Mol Imaging. 2017 Dec;61(4):414-428
pubmed: 28750497
Neuroscience. 2005;133(3):667-78
pubmed: 15890455
Lancet Neurol. 2014 Nov;13(11):1083-1091
pubmed: 25297012
Mol Neurobiol. 2015;51(3):1322-33
pubmed: 25064054
Nat Rev Neurosci. 2002 Sep;3(9):748-55
pubmed: 12209123
Nat Commun. 2022 Aug 11;13(1):4714
pubmed: 35953475
J Neuroinflammation. 2018 Jan 05;15(1):5
pubmed: 29304807
J Neurochem. 1976 Jan;26(1):141-7
pubmed: 1255165
Curr Biol. 2000 Feb 24;10(4):207-10
pubmed: 10704415
J Alzheimers Dis. 2011;26(3):447-55
pubmed: 21677376
J Nucl Med. 1979 Apr;20(4):350-7
pubmed: 43884
Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10955-9
pubmed: 1279699
J Gen Physiol. 2007 Jun;129(6):527-39
pubmed: 17535962
Neurochem Int. 2012 Jan;60(1):31-8
pubmed: 22080156
J Neurosci. 2002 Dec 1;22(23):10153-62
pubmed: 12451116
Neuron. 1996 Mar;16(3):675-86
pubmed: 8785064
J Neurochem. 2014 Mar;128(5):641-9
pubmed: 24224925
J Clin Invest. 2014 Mar;124(3):1255-67
pubmed: 24569372
Cold Spring Harb Perspect Med. 2011 Sep;1(1):a006189
pubmed: 22229116
Nat Commun. 2016 Nov 11;7:13441
pubmed: 27834383
Neurobiol Aging. 2011 Mar;32(3):553.e1-11
pubmed: 20416976
Eur J Neurol. 2018 Jan;25(1):59-70
pubmed: 28872215
J Neurosci Nurs. 2001 Oct;33(5):245-53
pubmed: 11668883
Life Sci. 2019 Dec 1;238:116969
pubmed: 31628912
Neurosci Lett. 1998 Jan 23;241(1):68-70
pubmed: 9502218
Brain. 2021 Dec 31;144(12):3742-3755
pubmed: 34145880
Eur J Pharmacol. 2004 Nov 28;505(1-3):145-9
pubmed: 15556147
Prog Neurobiol. 1990;35(4):245-96
pubmed: 1980745
J Exp Med. 2015 Mar 9;212(3):319-32
pubmed: 25711212
Neurobiol Learn Mem. 2021 Sep;183:107480
pubmed: 34153453
Acta Neuropathol. 2022 Jul;144(1):81-106
pubmed: 35596783
ACS Chem Neurosci. 2020 Feb 5;11(3):406-417
pubmed: 31909584
Neuroscience. 2009 Sep 15;162(4):1055-71
pubmed: 19328838
J Alzheimers Dis. 2011;24(2):287-300
pubmed: 21297271
J Med Chem. 2022 Sep 8;65(17):11703-11725
pubmed: 35984707
ACS Chem Neurosci. 2016 May 18;7(5):534-9
pubmed: 26918289
Int J Mol Sci. 2022 Oct 11;23(20):
pubmed: 36292973
Behav Brain Res. 2005 Jan 30;156(2):233-9
pubmed: 15582109
Nature. 1992 Dec 3;360(6403):467-71
pubmed: 1280334
Neurochem Int. 2012 Sep;61(4):523-30
pubmed: 22421531
NMR Biomed. 2011 Oct;24(8):943-57
pubmed: 21882281
Mol Pharmacol. 1997 Jul;52(1):6-15
pubmed: 9224806
Science. 1994 Jun 17;264(5166):1772-5
pubmed: 8209258
J Neurochem. 1977 May;28(5):1145-6
pubmed: 864464
Mol Pharmacol. 2007 Nov;72(5):1228-37
pubmed: 17646426
Nature. 2009 Dec 17;462(7275):880-5
pubmed: 19924125
Lancet. 2017 Nov 4;390(10107):2084-2098
pubmed: 28552366
J Neurochem. 2001 Oct;79(2):297-302
pubmed: 11677257
Sci Adv. 2021 Mar 3;7(10):
pubmed: 33658209
Nature. 2007 Jan 25;445(7126):387-93
pubmed: 17230192
Brain Res. 2010 Feb 26;1316:27-34
pubmed: 20026319
Ann Neurol. 1995 Jul;38(1):73-84
pubmed: 7611729
Front Mol Neurosci. 2017 Dec 19;10:427
pubmed: 29311817
Brain Res Bull. 1998;45(3):233-8
pubmed: 9510415
J Cell Sci. 2004 Oct 15;117(Pt 22):5417-26
pubmed: 15466883
J Med Chem. 2016 Oct 13;59(19):8771-8786
pubmed: 27636002
J Biol Chem. 2007 Nov 2;282(44):32480-90
pubmed: 17823119
J Neurochem. 1998 Sep;71(3):1315-20
pubmed: 9721758
Neurosci Lett. 2011 Jun 22;497(2):139-43
pubmed: 21569822
Eur J Pharmacol. 2008 Jan 14;578(2-3):171-6
pubmed: 18036519
Neurochem Int. 2002 Nov;41(5):313-8
pubmed: 12176072
Neurotherapeutics. 2010 Oct;7(4):471-81
pubmed: 20880509
Prog Neurobiol. 2007 Apr;81(5-6):253-71
pubmed: 17169479
Sci Rep. 2018 Jan 24;8(1):1550
pubmed: 29367720
ACS Chem Neurosci. 2016 Jun 15;7(6):767-75
pubmed: 26991242
Mol Neurodegener. 2016 Jan 12;11:5
pubmed: 26759118
Nature. 2004 Oct 14;431(7010):811-8
pubmed: 15483603
J Neurochem. 2021 Jun;157(6):1946-1962
pubmed: 33619759
Proc Natl Acad Sci U S A. 2019 Oct 22;116(43):21800-21811
pubmed: 31591195
Eur J Pharmacol. 1991 Feb 26;194(1):131-2
pubmed: 1676372
PLoS One. 2013 Apr 17;8(4):e61177
pubmed: 23613806
J Biol Chem. 2013 Oct 4;288(40):28975-86
pubmed: 23955341
Front Mol Neurosci. 2018 Aug 15;11:281
pubmed: 30158854
J Neurochem. 2015 Sep;134(6):982-1007
pubmed: 26096891
J Neurosci Res. 1999 Jan 15;55(2):218-29
pubmed: 9972824
Am J Clin Nutr. 2009 Sep;90(3):867S-874S
pubmed: 19571220
J Neurosci. 1994 Sep;14(9):5559-69
pubmed: 7521911
Brain Commun. 2022 Aug 18;4(5):fcac199
pubmed: 36072646
Mol Pharmacol. 1999 Dec;56(6):1095-104
pubmed: 10570036
Ann Neurol. 2001 May;49(5):643-9
pubmed: 11357955
NPJ Schizophr. 2017 Sep 21;3(1):32
pubmed: 28935880
Chem Rev. 2023 Jan 11;123(1):105-229
pubmed: 36399832
Mol Pharmacol. 2004 Apr;65(4):1008-15
pubmed: 15044631
Brain. 2019 Oct 1;142(10):3116-3128
pubmed: 31504212
Front Aging Neurosci. 2019 Jul 24;11:176
pubmed: 31396074
Nat Chem. 2018 Jun;10(6):673-683
pubmed: 29736006
Front Cell Neurosci. 2021 Sep 13;15:702824
pubmed: 34588956
J Biol Chem. 2002 Aug 16;277(33):29847-55
pubmed: 12015317
Neurochem Int. 2016 Sep;98:19-28
pubmed: 27129805
Neuroscientist. 2002 Dec;8(6):562-73
pubmed: 12467378
ACS Chem Neurosci. 2019 Aug 21;10(8):3437-3453
pubmed: 31257852
J Clin Invest. 2019 May 21;129(8):3103-3120
pubmed: 31112137
Neuropharmacology. 2011 Jan;60(1):172-81
pubmed: 20708631
J Physiol. 2006 Nov 15;577(Pt 1):221-34
pubmed: 16973698
ACS Chem Neurosci. 2020 Jun 3;11(11):1573-1596
pubmed: 32343555
FEBS Lett. 2009 Jul 7;583(13):2194-200
pubmed: 19527721
Neuron. 1998 Mar;20(3):589-602
pubmed: 9539131
Hum Mol Genet. 2009 Sep 1;18(17):3217-26
pubmed: 19483195
Am J Pathol. 2011 Sep;179(3):1373-84
pubmed: 21777559
Mov Disord. 2017 Nov;32(11):1547-1556
pubmed: 28631864
Br J Anaesth. 2006 Aug;97(2):192-5
pubmed: 16793777
Acta Neuropathol Commun. 2020 Jul 8;8(1):102
pubmed: 32641150
J Neurosci Res. 2015 Jun;93(6):930-7
pubmed: 25601490
J Neurochem. 1984 Jan;42(1):1-11
pubmed: 6139418
Nature. 1995 Jun 15;375(6532):599-603
pubmed: 7791878
ASN Neuro. 2013 Oct 07;5(4):273-82
pubmed: 24059854
Drug Discov Today. 2003 Oct 15;8(20):927-33
pubmed: 14554156
J Neurochem. 2015 Apr;133(2):199-210
pubmed: 25626691
Front Neurosci. 2022 Aug 10;16:952096
pubmed: 36033606
J Neurosci. 1995 Mar;15(3 Pt 1):1835-53
pubmed: 7891138
World J Psychiatry. 2018 Jun 28;8(2):51-63
pubmed: 29988908
J Neurochem. 2020 Nov;155(4):348-369
pubmed: 32320074
Nat Neurosci. 2021 Mar;24(3):312-325
pubmed: 33589835
J Neurosci. 2015 Apr 1;35(13):5260-70
pubmed: 25834051
Glia. 2014 Aug;62(8):1270-83
pubmed: 24782323
Glia. 2012 Jul;60(7):1024-36
pubmed: 22488924
J Neuropathol Exp Neurol. 2010 Jul;69(7):667-76
pubmed: 20535038
Sci Rep. 2018 Jan 26;8(1):1712
pubmed: 29374250
Mol Pharmacol. 1997 May;51(5):809-15
pubmed: 9145919
Neuropathol Appl Neurobiol. 2022 Feb;48(1):e12753
pubmed: 34297416
J Nutr. 2000 Apr;130(4S Suppl):1007S-15S
pubmed: 10736372
Neural Plast. 2019 Sep 9;2019:1247276
pubmed: 31582965
Brain Res Mol Brain Res. 1997 Dec 1;52(1):17-31
pubmed: 9450673
J Neurochem. 1979 Jan;32(1):121-7
pubmed: 759563
Bioorg Med Chem Lett. 2007 Mar 15;17(6):1651-4
pubmed: 17267220
J Neurosci. 2006 Jan 11;26(2):644-54
pubmed: 16407562
Trends Pharmacol Sci. 1998 Aug;19(8):328-34
pubmed: 9745361
Brain. 2017 Jul 1;140(7):1825-1828
pubmed: 29177498
Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1604-9
pubmed: 11818550
J Neurotrauma. 2016 Jun 1;33(11):1073-83
pubmed: 26200170
J Neurol Neurosurg Psychiatry. 2017 Jul;88(7):537
pubmed: 28209650
Front Neurosci. 2019 Sep 10;13:951
pubmed: 31551700
Exp Neurol. 2000 Jun;163(2):381-7
pubmed: 10833311
Mol Cell Neurosci. 2009 Apr;40(4):463-73
pubmed: 19340933
J Med Chem. 2008 Jul 24;51(14):4085-92
pubmed: 18578477
J Biol Chem. 1996 Jun 28;271(26):15303-6
pubmed: 8663435
Br J Pharmacol. 2003 Nov;140(5):839-46
pubmed: 14517179
Bioorg Med Chem Lett. 2011 Oct 1;21(19):5774-7
pubmed: 21875806
J Biol Chem. 2020 Mar 27;295(13):4359-4366
pubmed: 32079674
Ann N Y Acad Sci. 1999;890:385-99
pubmed: 10668444
Int J Biochem Cell Biol. 2017 Apr;85:75-84
pubmed: 28189841
J Biomol Screen. 2010 Jul;15(6):653-62
pubmed: 20508255
Ann Neurol. 1996 Nov;40(5):759-66
pubmed: 8957017
J Neurosci. 2004 Feb 4;24(5):1136-48
pubmed: 14762132
Front Cell Neurosci. 2017 Mar 21;11:80
pubmed: 28377696
J Parkinsons Dis. 2022;12(1):295-314
pubmed: 34719508
ACS Chem Neurosci. 2018 Mar 21;9(3):522-534
pubmed: 29140675
Adv Neurobiol. 2017;16:297-314
pubmed: 28828617
Sci Rep. 2018 Jun 7;8(1):8718
pubmed: 29880815
Neurobiol Dis. 2006 Mar;21(3):556-67
pubmed: 16274998
J Neurosci. 2009 Oct 14;29(41):12957-69
pubmed: 19828810
EMBO Rep. 2006 Sep;7(9):940-6
pubmed: 16906128
J Biol Chem. 2005 Oct 14;280(41):34924-32
pubmed: 16079146
JAMA. 2015 May 19;313(19):1939-49
pubmed: 25988463
J Neuroinflammation. 2014 Mar 06;11:42
pubmed: 24597481
Exp Neurol. 2017 Jun;292:145-153
pubmed: 28342750
Mol Pharmacol. 1998 Feb;53(2):195-201
pubmed: 9463476
Mol Pharmacol. 2005 Oct;68(4):974-82
pubmed: 16014807
J Neurol. 1999 Dec;246(12):1140-4
pubmed: 10653305
Science. 1997 Jun 13;276(5319):1699-702
pubmed: 9180080
Neuroscience. 1997 Jun;78(4):929-33
pubmed: 9174061
EJNMMI Radiopharm Chem. 2021 Oct 9;6(1):34
pubmed: 34628570
Brain Res Brain Res Rev. 1998 May;26(2-3):230-5
pubmed: 9651535
Front Aging Neurosci. 2018 Apr 26;10:122
pubmed: 29755340
Neuropathol Appl Neurobiol. 2022 Aug;48(5):e12811
pubmed: 35274343
J Neurosci. 1998 Nov 1;18(21):8751-7
pubmed: 9786982
Neurochem Int. 2003 Sep-Oct;43(4-5):371-80
pubmed: 12742081
J Neurochem. 2010 May;113(4):978-89
pubmed: 20193040
J Alzheimers Dis. 2018;66(4):1731-1743
pubmed: 30452416
J Neurosci. 2014 Jun 4;34(23):7886-98
pubmed: 24899711