From mouse to human: Accessing the biochemistry of vision in vivo by two-photon excitation.
In vivo retinal imaging
Optical nonlinear processes
Retina
Retinoid cycle
Two-photon SLO
Two-photon absorption
Two-photon excited fluorescence
Two-photon vision
Vision
Journal
Progress in retinal and eye research
ISSN: 1873-1635
Titre abrégé: Prog Retin Eye Res
Pays: England
ID NLM: 9431859
Informations de publication
Date de publication:
03 2023
03 2023
Historique:
received:
11
12
2022
revised:
03
02
2023
accepted:
06
02
2023
pubmed:
15
2
2023
medline:
11
3
2023
entrez:
14
2
2023
Statut:
ppublish
Résumé
The eye is an ideal organ for imaging by a multi-photon excitation approach, because ocular tissues such as the sclera, cornea, lens and neurosensory retina, are highly transparent to infrared (IR) light. The interface between the retina and the retinal pigment epithelium (RPE) is especially informative, because it reflects the health of the visual (retinoid) cycle and its changes in response to external stress, genetic manipulations, and drug treatments. Vitamin A-derived retinoids, like retinyl esters, are natural fluorophores that respond to multi-photon excitation with near IR light, bypassing the filter-like properties of the cornea, lens, and macular pigments. Also, during natural aging some retinoids form bisretinoids, like diretinoid-pyridiniumethanolamine (A2E), that are highly fluorescent. These bisretinoids appear to be elevated concurrently with aging. Vitamin A-derived retinoids and bisretinoidss are detected by two-photon ophthalmoscopy (2PO), using a new class of light sources with adjustable spatial, temporal, and spectral properties. Furthermore, the two-photon (2P) absorption of IR light by the visual pigments in rod and cone photoreceptors can initiate visual transduction by cis-trans isomerization of retinal, enabling parallel functional studies. Recently we overcame concerns about safety, data interpretation and complexity of the 2P-based instrumentation, the major roadblocks toward advancing this modality to the clinic. These imaging and retina-function assessment advancements have enabled us to conduct the first 2P studies with humans.
Identifiants
pubmed: 36787681
pii: S1350-9462(23)00009-5
doi: 10.1016/j.preteyeres.2023.101170
pmc: PMC10463242
mid: NIHMS1924269
pii:
doi:
Substances chimiques
Vitamin A
11103-57-4
Retinoids
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
101170Subventions
Organisme : NEI NIH HHS
ID : R01 EY009339
Pays : United States
Organisme : NEI NIH HHS
ID : R24 EY027283
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest K.P. is the Chief Scientific Officer of Polgenix Inc., and a consultant for Editas Medicine. K.P. is Chief Scientific Officer at Polgenix, Inc. K.P. is an inventor of U.S. patents 7,706,863 and 8,346,345, whose values may be affected by this publication. G.P. is an employee of Polgenix, Inc. M.W. declared no conflict of interest exists.
Références
Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):15123-8
pubmed: 17848510
Int J Retina Vitreous. 2016 Apr 8;2:12
pubmed: 27847630
J Clin Invest. 2022 Jan 18;132(2):
pubmed: 34847075
Transl Vis Sci Technol. 2020 Jul 07;9(8):7
pubmed: 32855854
Proc Natl Acad Sci U S A. 2020 Aug 18;117(33):19629-19638
pubmed: 32759209
Ophthalmology. 1998 Mar;105(3):412-6
pubmed: 9499769
Nat Biotechnol. 2003 Nov;21(11):1369-77
pubmed: 14595365
J Clin Invest. 2013 Dec;123(12):5119-34
pubmed: 24231350
Chem Rev. 2014 Jan 8;114(1):194-232
pubmed: 23905688
J Biol Chem. 2009 May 29;284(22):15173-83
pubmed: 19304658
Inflamm Allergy Drug Targets. 2011 Dec;10(6):497-508
pubmed: 21999177
J Cell Biol. 2004 Aug 16;166(4):447-53
pubmed: 15314061
Am J Ophthalmol Case Rep. 2022 Oct 13;28:101724
pubmed: 36324628
Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13658-63
pubmed: 16150724
J Opt Soc Am A Opt Image Sci Vis. 2007 May;24(5):1457-67
pubmed: 17429493
Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7951-7956
pubmed: 30944223
Biomed Opt Express. 2020 Sep 15;11(10):5586-5602
pubmed: 33149973
J Lipid Res. 2010 Feb;51(2):247-61
pubmed: 19666736
Science. 2011 Jun 10;332(6035):1307-12
pubmed: 21659602
Nat Med. 2010 Dec;16(12):1444-9
pubmed: 21076393
Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13138-13143
pubmed: 27729536
J Biol Chem. 2004 Mar 12;279(11):10422-32
pubmed: 14684738
J Opt Soc Am. 1963 Jun;53:765-6
pubmed: 13998626
Biomed Opt Express. 2020 Dec 17;12(1):462-479
pubmed: 33659083
J Biol Chem. 2019 Dec 13;294(50):19137-19154
pubmed: 31694912
Nat Protoc. 2011 Sep 08;6(10):1500-20
pubmed: 21959234
Proc Natl Acad Sci U S A. 2022 Nov 08;119(45):e2213911119
pubmed: 36322748
J Biol Chem. 2021 Jan-Jun;296:100072
pubmed: 33187985
Vision Res. 2003 Dec;43(28):2983-90
pubmed: 14611934
Nat Genet. 1998 Dec;20(4):344-51
pubmed: 9843205
J Opt Soc Am A Opt Image Sci Vis. 2003 Nov;20(11):2010-5
pubmed: 14620328
Invest Ophthalmol Vis Sci. 2009 Nov;50(11):5435-43
pubmed: 19553623
Eye (Lond). 2018 Jun;32(6):1010-1020
pubmed: 29398697
Nature. 1960 Oct 8;188:114-8
pubmed: 13724150
J Biol Chem. 2011 May 13;286(19):17248-58
pubmed: 21454509
J Clin Invest. 2015 Jul 1;125(7):2781-94
pubmed: 26075817
Opt Lett. 1994 Jun 1;19(11):780-2
pubmed: 19844443
J Gen Physiol. 1952 Nov;36(2):269-315
pubmed: 13011282
Br J Ophthalmol. 2011 Feb;95(2):162-5
pubmed: 20494915
Cell. 2005 Aug 12;122(3):449-59
pubmed: 16096063
Sci Rep. 2016 Sep 07;6:32223
pubmed: 27599635
Nat Biomed Eng. 2021 Feb;5(2):169-178
pubmed: 33077938
Nat Genet. 2000 Nov;26(3):270-1
pubmed: 11062461
Eur J Histochem. 2014 Dec 12;58(4):2461
pubmed: 25578980
Biochemistry. 2012 Feb 28;51(8):1625-37
pubmed: 22324807
Sci Adv. 2021 Apr 28;7(18):
pubmed: 33910906
Biomed Opt Express. 2012 Apr 1;3(4):715-34
pubmed: 22574260
Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):E5445-54
pubmed: 25453064
JCI Insight. 2018 Sep 6;3(17):
pubmed: 30185665
Ann Transl Med. 2021 Aug;9(15):1270
pubmed: 34532407
Nefrologia. 2017 Nov - Dec;37(6):653-655
pubmed: 29122213
Nat Med. 2014 Jul;20(7):785-9
pubmed: 24952647
J Opt Soc Am A Opt Image Sci Vis. 2007 May;24(5):1250-65
pubmed: 17429471
Diagnostics (Basel). 2022 Mar 21;12(3):
pubmed: 35328313
Science. 1990 Apr 6;248(4951):73-6
pubmed: 2321027
Am J Ophthalmol. 1980 Dec;90(6):810-6
pubmed: 7446668
J Ophthalmol. 2012;2012:786870
pubmed: 22523653
J Opt Soc Am. 1976 Apr;66(4):339-41
pubmed: 1262982
Biomed Opt Express. 2016 Jun 20;7(7):2671-91
pubmed: 27446697
PLoS Med. 2005 Nov;2(11):e333
pubmed: 16250670
Int Ophthalmol. 2009 Aug;29(4):289-91
pubmed: 18825317
Invest Ophthalmol Vis Sci. 2019 Jul 1;60(8):3054-3063
pubmed: 31348823
Annu Rev Biophys. 2021 May 6;50:575-593
pubmed: 33957055
J Biol Chem. 2008 Sep 26;283(39):26684-93
pubmed: 18658157
Invest Ophthalmol Vis Sci. 2021 Dec 1;62(15):23
pubmed: 34935882
Prog Retin Eye Res. 2017 Sep;60:120-143
pubmed: 28673870
Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8162-7
pubmed: 15917330
J Vis. 2017 Mar 1;17(3):10
pubmed: 28355623
Drug Des Devel Ther. 2013 Aug 05;7:711-22
pubmed: 23990705
Invest Ophthalmol Vis Sci. 1995 Mar;36(3):718-29
pubmed: 7890502
Microsc Res Tech. 2007 May;70(5):410-9
pubmed: 17393496
J Biol Chem. 2016 Dec 23;291(52):26937-26949
pubmed: 27875314
J Opt Soc Am. 1947 Jul;37(7):546-54
pubmed: 20256359
J Biol Chem. 1964 Dec;239:4073-6
pubmed: 14247650
Nat Chem Biol. 2015 Jan;11(1):26-32
pubmed: 25383759
Hum Mol Genet. 2015 Jun 1;24(11):3220-37
pubmed: 25712131
Pharmaceutics. 2019 Jul 31;11(8):
pubmed: 31370346
J Microsc. 2010 Apr 1;238(1):1-20
pubmed: 20384833
Annu Rev Vis Sci. 2021 Sep 15;7:665-692
pubmed: 34102066
Nature. 1968 Aug 24;219(5156):800-7
pubmed: 4876934
Pflugers Arch. 2007 Aug;454(5):805-19
pubmed: 17226052
Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):E1428-37
pubmed: 24706832
Opt Express. 2006 Jan 23;14(2):487-97
pubmed: 19503363
J Biomed Opt. 2018 Sep;23(9):1-20
pubmed: 30182580
Biomed Eng Online. 2006 Jun 06;5:36
pubmed: 16756664
Methods Enzymol. 2000;316:313-24
pubmed: 10800683
Methods Mol Biol. 2015;1232:273-90
pubmed: 25331141
Ophthalmology. 2017 Nov;124(11):1690-1711
pubmed: 28655539
Methods Mol Biol. 2010;652:247-61
pubmed: 20552433
Proc Natl Acad Sci U S A. 2020 Sep 8;117(36):22532-22543
pubmed: 32848058
J Refract Surg. 2002 Sep-Oct;18(5):S652-60
pubmed: 12361175
Appl Opt. 1988 Mar 15;27(6):1064-8
pubmed: 20531520
Prog Retin Eye Res. 2012 Mar;31(2):121-35
pubmed: 22209824
Anal Chem. 2022 Oct 18;94(41):14185-14194
pubmed: 36190014
Biochim Biophys Acta. 2016 Nov;1858(11):2625-2635
pubmed: 27480804
Sci Rep. 2022 Feb 4;12(1):1961
pubmed: 35121766
Invest Ophthalmol Vis Sci. 2003 Feb;44(2):826-38
pubmed: 12556419
Retina. 2021 Jun 1;41(6):1302-1308
pubmed: 33323904
J Biol Chem. 2013 Nov 29;288(48):34484-93
pubmed: 24129572
Opt Lett. 2007 Mar 15;32(6):659-61
pubmed: 17308593
Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):7075-80
pubmed: 12756303
Bioconjug Chem. 2021 Mar 17;32(3):572-583
pubmed: 33677964
J Cell Biol. 2004 Feb 2;164(3):373-83
pubmed: 14745001
Invest Ophthalmol Vis Sci. 2000 Oct;41(11):3569-75
pubmed: 11006254
J Med Chem. 2021 Jun 24;64(12):8287-8302
pubmed: 34081480
Mol Pharmacol. 2015;87(3):477-91
pubmed: 25538117
Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12413-8
pubmed: 16116091
Biomed Opt Express. 2022 Mar 17;13(4):2186-2201
pubmed: 35519256
Proc Natl Acad Sci U S A. 1992 Feb 15;89(4):1271-5
pubmed: 1741380
Annu Rev Biochem. 2006;75:743-67
pubmed: 16756510
Percept Psychophys. 1999 Jan;61(1):87-106
pubmed: 10070202
Nat Methods. 2006 Oct;3(10):781-2
pubmed: 16990808
Biomed Opt Express. 2015 Aug 13;6(9):3352-61
pubmed: 26417507
Invest Ophthalmol Vis Sci. 2014 Jun 26;55(7):4438-47
pubmed: 24970255
N Engl J Med. 1999 Apr 8;340(14):1063-70
pubmed: 10194235
Ophthalmology. 2005 Jun;112(6):1048-53
pubmed: 15885778
Science. 2006 Sep 15;313(5793):1642-5
pubmed: 16902090
J Biol Chem. 2015 Feb 20;290(8):4941-4952
pubmed: 25538233
Invest Ophthalmol Vis Sci. 2016 Feb;57(2):759-70
pubmed: 26927569
Retina. 2010 Jul-Aug;30(7):1090-4
pubmed: 20616686
Sci Adv. 2020 Sep 9;6(37):
pubmed: 32917686
J Am Chem Soc. 2008 Oct 29;130(43):14076-7
pubmed: 18831587
J Biomed Opt. 2009 Sep-Oct;14(5):054041
pubmed: 19895142
Prog Retin Eye Res. 2001 Jul;20(4):469-529
pubmed: 11390257
Invest Ophthalmol Vis Sci. 2015 May;56(5):3393-406
pubmed: 26024124
Nat Rev Drug Discov. 2016 Jun;15(6):385-403
pubmed: 26775688
Invest Ophthalmol Vis Sci. 2020 Sep 1;61(11):34
pubmed: 32945842
Nat Genet. 1997 Mar;15(3):236-46
pubmed: 9054934
Transl Vis Sci Technol. 2021 Feb 5;10(2):11
pubmed: 34003895
Can J Ophthalmol. 2013 Oct;48(5):350-7
pubmed: 24093179
J Biol Chem. 1999 Feb 5;274(6):3834-41
pubmed: 9920938
J Biol Chem. 2012 Feb 10;287(7):5059-69
pubmed: 22184108
Eye (Lond). 2012 Feb;26 Suppl 1:S2-21
pubmed: 22302094
Biomed Opt Express. 2020 Sep 15;11(10):5603-5617
pubmed: 33149974
Neuroscience. 2019 Sep 15;416:100-108
pubmed: 31400484
Biomed Opt Express. 2019 Aug 09;10(9):4551-4567
pubmed: 31565509
Nat Chem Biol. 2011 Dec 25;8(2):170-8
pubmed: 22198730
Opt Express. 2012 Jun 4;20(12):12729-41
pubmed: 22714302
Biomed Opt Express. 2010 Dec 17;2(1):139-48
pubmed: 21326644
J Biol Chem. 2018 Dec 14;293(50):19400-19410
pubmed: 30352873
Biomed Opt Express. 2013 Oct 18;4(11):2527-39
pubmed: 24298413