Investigation of Shared Genetic Risk Factors Between Parkinson's Disease and Cancers.

Humans Male Female Parkinson Disease / epidemiology Genome-Wide Association Study Genetic Predisposition to Disease / genetics Polymorphism, Single Nucleotide / genetics Melanoma / epidemiology Prostatic Neoplasms Ovarian Neoplasms Risk Factors Lung Neoplasms
Parkinson's disease cancer genetic correlation pleiotropy polygenic risk score

Journal

Movement disorders : official journal of the Movement Disorder Society
ISSN: 1531-8257
Titre abrégé: Mov Disord
Pays: United States
ID NLM: 8610688

Informations de publication

Date de publication:
04 2023
Historique:
revised: 07 12 2022
received: 26 09 2022
accepted: 28 12 2022
medline: 18 4 2023
pubmed: 15 2 2023
entrez: 14 2 2023
Statut: ppublish

Résumé

Epidemiological studies that examined the association between Parkinson's disease (PD) and cancers led to inconsistent results, but they face a number of methodological difficulties. We used results from genome-wide association studies (GWASs) to study the genetic correlation between PD and different cancers to identify common genetic risk factors. We used individual data for participants of European ancestry from the Courage-PD (Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease; PD, N = 16,519) and EPITHYR (differentiated thyroid cancer, N = 3527) consortia and summary statistics of GWASs from iPDGC (International Parkinson Disease Genomics Consortium; PD, N = 482,730), Melanoma Meta-Analysis Consortium (MMAC), Breast Cancer Association Consortium (breast cancer), the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (prostate cancer), International Lung Cancer Consortium (lung cancer), and Ovarian Cancer Association Consortium (ovarian cancer) (N comprised between 36,017 and 228,951 for cancer GWASs). We estimated the genetic correlation between PD and cancers using linkage disequilibrium score regression. We studied the association between PD and polymorphisms associated with cancers, and vice versa, using cross-phenotypes polygenic risk score (PRS) analyses. We confirmed a previously reported positive genetic correlation of PD with melanoma (G We show evidence in favor of a contribution of pleiotropic genes to the association between PD and specific cancers. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.

Sections du résumé

BACKGROUND
Epidemiological studies that examined the association between Parkinson's disease (PD) and cancers led to inconsistent results, but they face a number of methodological difficulties.
OBJECTIVE
We used results from genome-wide association studies (GWASs) to study the genetic correlation between PD and different cancers to identify common genetic risk factors.
METHODS
We used individual data for participants of European ancestry from the Courage-PD (Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease; PD, N = 16,519) and EPITHYR (differentiated thyroid cancer, N = 3527) consortia and summary statistics of GWASs from iPDGC (International Parkinson Disease Genomics Consortium; PD, N = 482,730), Melanoma Meta-Analysis Consortium (MMAC), Breast Cancer Association Consortium (breast cancer), the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (prostate cancer), International Lung Cancer Consortium (lung cancer), and Ovarian Cancer Association Consortium (ovarian cancer) (N comprised between 36,017 and 228,951 for cancer GWASs). We estimated the genetic correlation between PD and cancers using linkage disequilibrium score regression. We studied the association between PD and polymorphisms associated with cancers, and vice versa, using cross-phenotypes polygenic risk score (PRS) analyses.
RESULTS
We confirmed a previously reported positive genetic correlation of PD with melanoma (G
CONCLUSIONS
We show evidence in favor of a contribution of pleiotropic genes to the association between PD and specific cancers. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.

Identifiants

DOI: 10.1002/mds.29337 PMID: 36788297 PMC: PMC10334300
pubmed: 36788297
doi: 10.1002/mds.29337
pmc: PMC10334300
mid: NIHMS1867494
doi:

Types de publication

Meta-Analysis Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

604-615

Subventions

Organisme : NCI NIH HHS
ID : R01 CA225662
Pays : United States
Organisme : Cancer Research UK
ID : C12292/A11174
Pays : United Kingdom
Organisme : NIH HHS
ID : U01-CA98233
Pays : United States
Organisme : Department of Health
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : U19 CA203654
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA188392
Pays : United States
Organisme : Cancer Research UK
ID : A8197/A16565
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C5047/A10692
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : U01 CA098758
Pays : United States
Organisme : NCI NIH HHS
ID : U19 CA148065
Pays : United States
Organisme : NCI NIH HHS
ID : NIH NCI U01 CA188392
Pays : United States
Organisme : Cancer Research UK
ID : C16913/A6135
Pays : United Kingdom
Organisme : NIH HHS
ID : NIH U19 CA203654
Pays : United States
Organisme : Susan G. Komen
Pays : United States
Organisme : Cancer Research UK
ID : C5047/A3354
Pays : United Kingdom
Organisme : NIH HHS
ID : U01-CA98710
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA098216
Pays : United States
Organisme : Cancer Research UK
ID : C5047/A33
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C5047/A7357
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C5047/A8384
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : R01 CA128978
Pays : United States
Organisme : Cancer Research UK
ID : C1287/A10118
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : U19 CA148537
Pays : United States
Organisme : NIH HHS
ID : X01HG007492
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA098233
Pays : United States
Organisme : NHGRI NIH HHS
Pays : United States
Organisme : NIH HHS
ID : CA128978
Pays : United States
Organisme : NCI NIH HHS
ID : U19 CA148112
Pays : United States
Organisme : Cancer Research UK
ID : C1281/A12014
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C1281
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C1287/A10710
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C1287/A16563
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 209057
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : U01 CA098710
Pays : United States

Informations de copyright

© 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.

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Auteurs

Pierre-Emmanuel Sugier (PE)

Université Paris-Saclay, UVSQ, Inserm, Gustave Roussy, Team "Exposome, Heredity, Cancer and Health", CESP, Villejuif, France.
Laboratoire de Mathématiques et de leurs Applications de Pau, E2S UPPA, CNRS, Pau, France.
ORCID: 0000-0002-5846-1104

Elise A Lucotte (EA)

Université Paris-Saclay, UVSQ, Inserm, Gustave Roussy, Team "Exposome, Heredity, Cancer and Health", CESP, Villejuif, France.

Cloé Domenighetti (C)

Université Paris-Saclay, UVSQ, Inserm, Gustave Roussy, Team "Exposome, Heredity, Cancer and Health", CESP, Villejuif, France.
ORCID: 0000-0001-6408-0351

Matthew H Law (MH)

Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Faculty of Health, Queensland University of Technology, Brisbane, Australia.

Mark M Iles (MM)

Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom.

Kevin Brown (K)

Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

Christopher Amos (C)

Institute for Clinical and Translational Research, Baylor Medical College of Medecine, Houston, Texas, USA.

James D McKay (JD)

International Agency for Research on Cancer, Lyon, France.

Rayjean J Hung (RJ)

Lunenfeld-Tanenbuaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.

Mojgan Karimi (M)

Université Paris-Saclay, UVSQ, Inserm, Gustave Roussy, Team "Exposome, Heredity, Cancer and Health", CESP, Villejuif, France.

Delphine Bacq-Daian (D)

Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, Evry, France.

Anne Boland-Augé (A)

Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, Evry, France.

Robert Olaso (R)

Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, Evry, France.

Jean-François Deleuze (JF)

Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, Evry, France.

Fabienne Lesueur (F)

Inserm, U900, Institut Curie, PSL University, Mines ParisTech, Paris, France.

Evgenia Ostroumova (E)

International Agency for Research on Cancer, Lyon, France.

Ausrele Kesminiene (A)

International Agency for Research on Cancer, Lyon, France.

Florent de Vathaire (F)

Université Paris-Saclay, UVSQ, Gustave Roussy, Inserm, Team "Epidemiology of radiations," CESP, Villejuif, France.

Pascal Guénel (P)

Université Paris-Saclay, UVSQ, Inserm, Gustave Roussy, Team "Exposome, Heredity, Cancer and Health", CESP, Villejuif, France.

Ashwin Ashok Kumar Sreelatha (AAK)

Centre for Genetic Epidemiology, Institute for Clinical Epidemiology and Applied Biometry, University of Tubingen, Tübingen, Germany.

Claudia Schulte (C)

Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tubingen, Tübingen, Germany.
German Center for Neurodegenerative Diseases, Tübingen, Germany.
ORCID: 0000-0003-4006-1265

Sandeep Grover (S)

Centre for Genetic Epidemiology, Institute for Clinical Epidemiology and Applied Biometry, University of Tubingen, Tübingen, Germany.
ORCID: 0000-0003-2615-4916

Patrick May (P)

Translational Neuroscience, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-Belval, Luxembourg.
ORCID: 0000-0001-8698-3770

Dheeraj R Bobbili (DR)

Translational Neuroscience, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-Belval, Luxembourg.
ORCID: 0000-0002-1368-9623

Milena Radivojkov-Blagojevic (M)

Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany.

Peter Lichtner (P)

Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany.

Andrew B Singleton (AB)

Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.
Center For Alzheimer's and Related Dementias, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.

Dena G Hernandez (DG)

Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.

Connor Edsall (C)

Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.

George D Mellick (GD)

Griffith Institute for Drug Discovery, Griffith University, Nathan, Australia.

Alexander Zimprich (A)

Department of Neurology, Medical University of Vienna, Vienna, Austria.
ORCID: 0000-0002-1668-5177

Walter Pirker (W)

Department of Neurology, Klinik Ottakring, Vienna, Austria.

Ekaterina Rogaeva (E)

Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.

Anthony E Lang (AE)

Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Toronto, Ontario, Canada.
Division of Neurology, University of Toronto, Toronto, Ontario, Canada.
Krembil Brain Institute, Toronto, Ontario, Canada.
ORCID: 0000-0003-1229-3667

Sulev Koks (S)

Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Murdoch, Australia.
Perron Institute for Neurological and Translational Science, Nedlands, Australia.

Pille Taba (P)

Department of Neurology and Neurosurgery, University of Tartu, Tartu, Estonia.
Neurology Clinic, Tartu University Hospital, Tartu, Estonia.

Suzanne Lesage (S)

Department of Neurology, Sorbonne Université, Institut du Cerveau-Paris Brain Institute-ICM, INSERM, CNRS, Assistance Publique Hôpitaux de Paris, Paris, France.

Alexis Brice (A)

Department of Neurology, Sorbonne Université, Institut du Cerveau-Paris Brain Institute-ICM, INSERM, CNRS, Assistance Publique Hôpitaux de Paris, Paris, France.

Jean-Christophe Corvol (JC)

Department of Neurology, Sorbonne Université, Institut du Cerveau-Paris Brain Institute-ICM, INSERM, CNRS, Assistance Publique Hôpitaux de Paris, Paris, France.
Assistance Publique Hôpitaux de Paris, Department of Neurology, CIC Neurosciences, Paris, France.
ORCID: 0000-0001-7325-0199

Marie-Christine Chartier-Harlin (MC)

Université de Lille, Inserm, CHU Lille, UMR-S 1172, LilNCog, Centre de Recherche Lille Neurosciences & Cognition, Lille, France.

Eugénie Mutez (E)

Université de Lille, Inserm, CHU Lille, UMR-S 1172, LilNCog, Centre de Recherche Lille Neurosciences & Cognition, Lille, France.
ORCID: 0000-0002-5947-0432

Kathrin Brockmann (K)

Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tubingen, Tübingen, Germany.
German Center for Neurodegenerative Diseases, Tübingen, Germany.
ORCID: 0000-0002-7515-8596

Angela B Deutschländer (AB)

Department of Neurology, Ludwig Maximilians University of Munich, Munich, Germany.
Department of Neurology, Max Planck Institute of Psychiatry, Munich, Germany.
ORCID: 0000-0003-2152-9926

Georges M Hadjigeorgiou (GM)

Department of Neurology and Department of Clinical Genomics, Mayo Clinic Florida, Jacksonville, Florida, USA.
Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, University Hospital of Larissa, Larissa, Greece.
Department of Neurology, Medical School, University of Cyprus, Nicosia, Cyprus.

Efthimios Dardiotis (E)

Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, University Hospital of Larissa, Larissa, Greece.

Leonidas Stefanis (L)

1st Department of Neurology, Eginition Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Center of Clinical Research, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
ORCID: 0000-0003-3569-8990

Athina Maria Simitsi (AM)

1st Department of Neurology, Eginition Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Enza Maria Valente (EM)

Department of Molecular Medicine, University of Pavia, Pavia, Italy.
Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Mondino Foundation, Pavia, Italy.
ORCID: 0000-0002-0600-6820

Simona Petrucci (S)

UOC Medical Genetics and Advanced Cell Diagnostics, S. Andrea University Hospital, Rome, Italy.
Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.

Letizia Straniero (L)

Department of Biomedical Sciences, Humanitas University, Milan, Italy.

Anna Zecchinelli (A)

Parkinson Institute, Azienda Socio Sanitaria Territoriale (ASST) Gaetano Pini/CTO, Milan, Italy.

Gianni Pezzoli (G)

Parkinson Institute, Fontazione Grigioni-Via Zuretti, Milan, Italy.

Laura Brighina (L)

Department of Neurology, San Gerardo Hospital, Monza, Italy.
Department of Medicine and Surgery and Milan Center for Neuroscience, University of Milano Bicocca, Milan, Italy.

Carlo Ferrarese (C)

Department of Neurology, San Gerardo Hospital, Monza, Italy.
Department of Medicine and Surgery and Milan Center for Neuroscience, University of Milano Bicocca, Milan, Italy.

Grazia Annesi (G)

Institute for Biomedical Research and Innovation, National Research Council, Cosenza, Italy.

Andrea Quattrone (A)

Institute of Neurology, Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy.
Department of Medical and Surgical Sciences, Neuroscience Research Center, Magna Graecia University, Catanzaro, Italy.

Monica Gagliardi (M)

Department of Medical and Surgical Sciences, Neuroscience Research Center, Magna Graecia University, Catanzaro, Italy.

Hirotaka Matsuo (H)

Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Saitama, Japan.

Akiyoshi Nakayama (A)

Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Saitama, Japan.

Nobutaka Hattori (N)

Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.

Kenya Nishioka (K)

Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.

Sun Ju Chung (SJ)

Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
ORCID: 0000-0003-4118-8233

Yun Joong Kim (YJ)

Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea.

Pierre Kolber (P)

Neurology, Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg.

Bart P C van de Warrenburg (BPC)

Department of Neurology, Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands.

Bastiaan R Bloem (BR)

Department of Neurology, Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands.

Jan Aasly (J)

Department of Neurology, St. Olav's Hospital and Norwegian University of Science and Technology, Trondheim, Norway.

Mathias Toft (M)

Department of Neurology, Oslo University Hospital, Oslo, Norway.
ORCID: 0000-0002-6723-6865

Lasse Pihlstrøm (L)

Department of Neurology, Oslo University Hospital, Oslo, Norway.

Leonor Correia Guedes (LC)

Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
Department of Neurosciences and Mental Health, Neurology, Hospital de Santa Maria, Centro Hospitalar Universitario Lisboa Norte (CHULN), Lisbon, Portugal.

Joaquim J Ferreira (JJ)

Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
Department of Neurosciences and Mental Health, Neurology, Hospital de Santa Maria, Centro Hospitalar Universitario Lisboa Norte (CHULN), Lisbon, Portugal.
Laboratory of Clinical Pharmacology and Therapeutics, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
ORCID: 0000-0003-3950-5113

Soraya Bardien (S)

Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa.
ORCID: 0000-0002-3508-3438

Jonathan Carr (J)

Division of Neurology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa.

Eduardo Tolosa (E)

Parkinson's Disease & Movement Disorders Unit, Neurology Service, Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.
Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED: CB06/05/0018-ISCIII), Barcelona, Spain.
ORCID: 0000-0002-3781-0854

Mario Ezquerra (M)

Lab of Parkinson's disease and Other Neurodegenerative Movement Disorders, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain.
ORCID: 0000-0003-3246-6641

Pau Pastor (P)

Unit of Neurodegenerative Diseases, Department of Neurology, University Hospital Germans Trias i Pujol, Barcelona, Spain.

Monica Diez-Fairen (M)

Fundació per la Recerca Biomèdica i Social Mútua Terrassa, Barcelona, Spain.
Movement Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Barcelona, Spain.

Karin Wirdefeldt (K)

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Nancy Pedersen (N)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Caroline Ran (C)

Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Andrea C Belin (AC)

Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Andreas Puschmann (A)

Lund University, Skåne University Hospital, Department of Clinical Sciences Lund, Neurology, Lund, Sweden.

Emil Ygland Rödström (EY)

Lund University, Skåne University Hospital, Department of Clinical Sciences Lund, Neurology, Lund, Sweden.

Carl E Clarke (CE)

University of Birmingham and Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, United Kingdom.

Karen E Morrison (KE)

Faculty of Medicine, Health and Life Sciences, Queens University, Belfast, United Kingdom.

Manuela Tan (M)

Department of Neurology, Oslo University Hospital, Oslo, Norway.
ORCID: 0000-0001-5835-669X

Dimitri Krainc (D)

Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

Lena F Burbulla (LF)

German Center for Neurodegenerative Diseases, Tübingen, Germany.
Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Metabolic Biochemistry, Biomedical Center, Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.
Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.

Matt J Farrer (MJ)

Department of Neurology, McKnight Brain Institute, University of Florida, Gainesville, Florida, USA.

Rejko Kruger (R)

Translational Neuroscience, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-Belval, Luxembourg.
Neurology, Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg.
Parkinson's Research Clinic, Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg.
Transversal Translational Medicine, Luxembourg Institute of Health, Strassen, Luxembourg.

Thomas Gasser (T)

Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tubingen, Tübingen, Germany.
German Center for Neurodegenerative Diseases, Tübingen, Germany.

Manu Sharma (M)

Centre for Genetic Epidemiology, Institute for Clinical Epidemiology and Applied Biometry, University of Tubingen, Tübingen, Germany.
Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tubingen, Tübingen, Germany.
ORCID: 0000-0002-1260-5416

Thérèse Truong (T)

Université Paris-Saclay, UVSQ, Inserm, Gustave Roussy, Team "Exposome, Heredity, Cancer and Health", CESP, Villejuif, France.

Alexis Elbaz (A)

Université Paris-Saclay, UVSQ, Inserm, Gustave Roussy, Team "Exposome, Heredity, Cancer and Health", CESP, Villejuif, France.
ORCID: 0000-0001-9724-5490

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Investigation of Shared Genetic Risk Factors...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Maladie de Parkinson › Investigation of Shared Genetic Risk Factors...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Investigation of Shared Genetic Risk Factors...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Investigation of Shared Genetic Risk Factors...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Investigation of Shared Genetic Risk Factors...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Naevus et mélanomes › Mélanome › Investigation of Shared Genetic Risk Factors...
questionsmedicales.fr › Maladies urogénitales › Tumeurs de l'appareil urogénital › Tumeurs de l'appareil génital mâle › Tumeurs de la prostate › Investigation of Shared Genetic Risk Factors...
questionsmedicales.fr › Maladies endocriniennes › Troubles gonadiques › Maladies ovariennes › Tumeurs de l'ovaire › Investigation of Shared Genetic Risk Factors...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Investigation of Shared Genetic Risk Factors...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Investigation of Shared Genetic Risk Factors...