Utility of a haemoglobin test of gingival crevicular fluid: A multicentre, observational study.
bleeding on probing
gingival crevicular fluid
haemoglobin
periodontitis
supportive periodontal therapy
Journal
Oral diseases
ISSN: 1601-0825
Titre abrégé: Oral Dis
Pays: Denmark
ID NLM: 9508565
Informations de publication
Date de publication:
15 Feb 2023
15 Feb 2023
Historique:
revised:
06
12
2022
received:
27
07
2022
accepted:
12
02
2023
pubmed:
16
2
2023
medline:
16
2
2023
entrez:
15
2
2023
Statut:
aheadofprint
Résumé
The purpose of this study was to verify the accuracy and utility of clinical parameters (plaque index, gingival crevicular fluid volume, probing depth, clinical attachment level, bleeding on probing and gingival index) and biochemical parameters (aspartate aminotransferase, protein and haemoglobin) in a longitudinal analysis during the supportive periodontal therapy period. A total of 279 test sites of 128 patients were investigated clinically and biochemically. After the first examination of clinical and biochemical parameters, periodontal support treatments were administered immediately and performed once every three months up to the second examination. All of the clinical and biochemical parameters were significantly lower at the second examination than at the first, except for the plaque index and bleeding on probing. Of these parameters, in particular, aspartate aminotransferase and haemoglobin in the gingival crevicular fluid were significantly reduced compared to those of the first examination in both the ≤4 and ≥5 mm probing depth groups, and they clearly suggested that periodontitis tended to recover. Adding the haemoglobin test to the bleeding on probing test strongly improves the accuracy of measurement of clinical parameters after periodontal treatment.
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Grants-in-Aid from the Ministry of Education and Science Research Funds
ID : Grant Nos. 20K09964 and 20K09981
Informations de copyright
© 2023 The Authors. Oral Diseases published by Wiley Periodicals LLC.
Références
Ainamo, J., & Bay, I. (1975). Problems and proposals for recording gingivitis and plaque. International Dental Journal, 25(4), 229-235.
Armitage, G. C., Svanberg, G. K., & Löe, H. (1977). Microscopic evaluation of clinical measurements of connective tissue attachment levels. Journal of Clinical Periodontology, 4(3), 173-190. https://doi.org/10.1111/j.1600-051x.1977.tb02271.x
Badersten, A., Nilveus, R., & Egelberg, J. (1981). Effect of nonsurgical periodontal therapy I. Moderately advanced periodontitis. Journal of Clinical Periodontology, 8(1), 57-72. https://doi.org/10.1111/j.1600-051x.1981.tb02024.x
Badersten, A., Nilveus, R., & Egelberg, J. (1984). Effect of nonsurgical periodontal therapy II. Severely advanced periodontitis. Journal of Clinical Periodontology, 11(1), 63-76. https://doi.org/10.1111/j.1600-051x.1984.tb01309.x
Badersten, A., Nilveus, R., & Egelberg, J. (1985). Effect of nonsurgical periodontal therapy VII. Bleeding, suppuration and probing depth in sites with probing attachment loss. Journal of Clinical Periodontology, 12(6), 432-440. https://doi.org/10.1111/j.1600-051X.1985.tb01379.x
Caffesse, R. G., Sweeney, P. L., & Smith, B. A. (1986). Scaling and root planing with and without periodontal flap surgery. Journal of Clinical Periodontology, 13(3), 205-210. https://doi.org/10.1111/j.1600-051x.1986.tb01461.x
Claffey, N., Nylund, K., Kiger, R., Garrett, S., & Egerberg, J. (1990). Diagnostic predictability of score plaque, bleeding, suppuration and probing depth for attachment loss. 3 1/2 years of observation following initial periodontal therapy. Journal of Clinical Periodontology, 17(2), 108-114. https://doi.org/10.1111/j.1600-051x.1990.tb01071.x
Fowler, C., Garrett, S., Crigger, M., & Egelberg, J. (1982). Histologic probe position in treated and untreated human periodontal tissues. Journal of Clinical Periodontology, 9(5), 373-385. https://doi.org/10.1111/j.1600-051X.1982.tb02048.x
Hanioka, T., Matsuse, R., Shigemoto, Y., Ojima, M., & Shizukuishi, S. (2005). Relationship between periodontal disease status and combination of biochemical assays of gingival crevicular fluid. Journal of Periodontal Research, 40(4), 331-338. https://doi.org/10.1111/j.1600-0765.2005.00807.x
Heft, M. W., Perelmuter, S. H., Cooper, B. Y., Magnusson, I., & Clark, W. B. (1991). Relationship between gingival inflammation and painfulness of periodontal probing. Journal of Clinical Periodontology, 18(3), 213-215. https://doi.org/10.1111/j.1600-051X.1991.tb01137.x
Herbert, F. W., & Thomas, M. H. (2006). Color atlas of dental hygiene: Periodontology (pp. 242-243). Thieme.
Ito, H., Numabe, Y., Hashimoto, S., Sekino, S., Murakashi, E., Ishiguro, I., Sasaki, D., Yaegashi, T., Takai, H., Mezawa, M., Ogata, Y., Watanabe, H., Hagiwara, S., Izumi, Y., Hiroshima, Y., Kido, J. I., Nagata, T., & Kunimatsu, K. (2016). Correlation between gingival crevicular fluid hemoglobin content and periodontal clinical parameters. Journal of Periodontology, 87(11), 1314-1319. https://doi.org/10.1902/jop.2016.160092
Ito, H., Numabe, Y., Hashimoto, S., Uehara, S., Wu, Y. H., & Ogawa, T. (2020). Usefulness of hemoglobin examination in gingival crevicular fluid during supportive periodontal therapy to diagnose the pre-symptomatic state in periodontal disease. Clinical Oral Investigations, 25, 487-495. https://doi.org/10.1007/s00784-020-03396-0
Ito, H., Numabe, Y., Sekino, S., Murakashi, E., Iguchi, I., Hashimoto, S., Sasaki, D., Yaegashi, T., Kunimatsu, K., Takai, H., Mezawa, M., Ogata, Y., Watanabe, H., Hagiwara, S., Izumi, Y., Hiroshima, Y., Kido, J., & Nagata, T. (2014). Evaluation of bleeding on probing and gingival crevicular fluid enzyme activity for detection of periodontally active sites during supportive periodontal therapy. Odontology, 102, 50-56. https://doi.org/10.1007/s10266-012-0090-1
Lang, N. P., Joss, A., Orsanic, T., Gusberti, F. A., & Siegrist, B. E. (1986). Bleeding on probing. A predictor for progression of periodontal disease? Journal of Clinical Periodontology, 13(6), 590-596. https://doi.org/10.1111/j.1600-051x.1986.tb00852.x
Listgarten, M. A. (1980). Periodontal probing: What does it mean? Journal of Clinical Periodontology, 7(3), 165-176. https://doi.org/10.1111/j.1600-051X.1980.tb01960.x
Löe, H. (1967). The gingival index, the plaque index and the retention index systems. Journal of Periodontology, 38(6), 610-616. https://doi.org/10.1902/jop.1967.38.6_part2.610
Mäkinen, K. K., Sewón, L., & Mäkinen, P. L. (1996). Analysis in gingival crevicular fluid of two oligopeptides derived from human hemoglobin β-chain. Journal of Periodontal Research, 31(1), 43-46. https://doi.org/10.1111/j.1600-0765.1996.tb00462.x
Page, R. C., & Kornman, K. S. (1997). The pathogenesis of human periodontitis: An introduction. Periodontology, 2000(14), 9-11. https://doi.org/10.1111/j.1600-0757.1997.tb00189.x
Silness, J., & Löe, H. (1964). Periodontal disease in pregnancy II. Correlation between oral hygiene and periodontal condition. Acta Odontologica Scandinavica, 22(1), 112-135. https://doi.org/10.3109/00016356408993968
Takeuchi-Hatanaka, K., Yasuda, T., Naruishi, K., Katsuragi-Fuke, K., Inubushi, J., Ootsuki, H., Maeda, H., & Takashiba, S. (2016). Effects of new over-the-counter periodontal ointment-containing applicator with single-tuft brush on cytokine levels in gingival crevicular fluid during supportive periodontal therapy phase: A randomized double-blind clinical trial. Journal of Periodontal Research, 51(3), 321-331. https://doi.org/10.1111/jre.12311
Tonetti, M. S., Greenwell, H., & Korman, K. S. (2018). Staging and grading of periodontitis: Framework and proposal of a new classification and case definition. Journal of Clinical Periodontology, 45(Suppl 20), S149-S161. https://doi.org/10.1111/jcpe.12945
Waerhaug, J. (1978). Healing of the dento-epithelial junction following subgingival plaque control. II: As observed on extracted teeth. Journal of Periodontology, 49(3), 119-134. https://doi.org/10.1902/jop.1978.49.3.119