Colorectal adenosquamous carcinoma: genomic profiling of a rare histotype of colorectal cancer.
Adenosquamous carcinoma
Colorectal carcinoma
Next-generation sequencing
Journal
Virchows Archiv : an international journal of pathology
ISSN: 1432-2307
Titre abrégé: Virchows Arch
Pays: Germany
ID NLM: 9423843
Informations de publication
Date de publication:
May 2023
May 2023
Historique:
received:
12
09
2022
accepted:
08
02
2023
revised:
23
12
2022
medline:
5
5
2023
pubmed:
16
2
2023
entrez:
15
2
2023
Statut:
ppublish
Résumé
Colorectal adenosquamous carcinoma (ASC) is exceedingly rare, comprising less than 0.1% of all colorectal malignancies, and is characterized by an aggressive disease course, with a higher metastatic rate and worse outcome than conventional colorectal adenocarcinoma. A comprehensive molecular profile of this group of neoplasms is still lacking. A total of 22 cases of colorectal ASCs (with 22 primary lesions and 7 metastases matched with 4 primaries) were subject to NGS targeting 67 cancer-related genes (VariantPlex solid tumor; Archer). Mismatch repair (MMR), p53, and
Identifiants
pubmed: 36790480
doi: 10.1007/s00428-023-03517-6
pii: 10.1007/s00428-023-03517-6
pmc: PMC10156896
doi:
Substances chimiques
Proto-Oncogene Proteins B-raf
EC 2.7.11.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
879-885Subventions
Organisme : Regione del Veneto
ID : NET-2016-02363853
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : AIRC 5 per mille 2019 (ID. 22759 program)
Informations de copyright
© 2023. The Author(s).
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