Immune cell counts in cerebrospinal fluid predict cognitive function in aging and neurodegenerative disease.
aging
cerebrospinal fluid
cognition
executive function
inflammation
neurodegeneration
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
08 2023
08 2023
Historique:
revised:
29
11
2022
received:
17
08
2022
accepted:
22
12
2022
pmc-release:
01
08
2024
medline:
11
8
2023
pubmed:
16
2
2023
entrez:
15
2
2023
Statut:
ppublish
Résumé
Immune dysfunction is important in aging and neurodegeneration; lacking clinically available tools limits research translation. We tested associations of cerebral spinal fluid (CSF) monocyte-to-lymphocyte ratio (MLR)-innate immune activation surrogate-with cognition in an aging and dementia cohort, hypothesizing that elevated MLR is associated with poorer executive functioning. CSF MLR was calculated in well-characterized, genotyped participants enrolled in studies of aging and dementia at University of California, San Francisco Memory and Aging Center (n = 199, mean age 57.5 years, SD 11.9). Linear models tested associations with episodic memory and executive function (verbal fluency, speeded set-shifting). Aging was associated with higher CSF monocyte, lower lymphocyte counts, and higher MLRs (p < 0.001). MLR was associated with verbal fluency (p < 0.05) only. Using clinical labs, we show an inverse association between CSF MLR and executive function in aging and dementia, supporting the utility of clinical labs in capturing associations between innate immune dysfunction and neurodegeneration.
Identifiants
pubmed: 36791265
doi: 10.1002/alz.12956
pmc: PMC10425564
mid: NIHMS1863205
doi:
Substances chimiques
Biomarkers
0
Amyloid beta-Peptides
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
3339-3349Subventions
Organisme : NIA NIH HHS
ID : P50 AG023501
Pays : United States
Organisme : CSRD VA
ID : IK2 CX002180
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG032289
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG019724
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG057234
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG032289
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG023481
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG062422
Pays : United States
Informations de copyright
© 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
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