Association Between Metformin Use and Cognitive and Physical Function in Persons with HIV and Diabetes.
HIV
aging
frailty
metformin
physical function
Journal
AIDS research and human retroviruses
ISSN: 1931-8405
Titre abrégé: AIDS Res Hum Retroviruses
Pays: United States
ID NLM: 8709376
Informations de publication
Date de publication:
06 2023
06 2023
Historique:
pmc-release:
01
06
2024
medline:
7
6
2023
pubmed:
17
2
2023
entrez:
16
2
2023
Statut:
ppublish
Résumé
Older persons with HIV (PWH) experience high rates of cognitive impairment and frailty, and accelerated decline in physical function compared with the general population. Metformin use has been associated with beneficial effects on cognitive and physical function among older adults without HIV. The relationship between metformin use on these outcomes in PWH has not been evaluated. AIDS Clinical Trials Group (ACTG) A5322 is an observational cohort study of older PWH with annual assessments for cognition and frailty, including measures of physical function (e.g., gait speed and grip strength). Participants with diabetes who were prescribed antihyperglycemic medications were included in this analysis to evaluate the association between metformin and functional outcomes. Cross-sectional, longitudinal, and time-to-event models were used to evaluate the relationship between metformin exposure with cognitive, physical function, and frailty outcomes. Ninety-eight PWH met inclusion criteria and were included in at least one model. No significant associations between metformin use, frailty, physical, or cognitive function were noted in unadjusted or adjusted cross-sectional, longitudinal, or time-to-event models (
Identifiants
pubmed: 36792952
doi: 10.1089/AID.2022.0129
pmc: PMC10278023
doi:
Substances chimiques
Metformin
9100L32L2N
Types de publication
Observational Study
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
302-309Subventions
Organisme : NIAID NIH HHS
ID : UM1 AI106701
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI069432
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI069471
Pays : United States
Organisme : NIAID NIH HHS
ID : K24 AI120834
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI068634
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG059988
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL146201
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002384
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI068636
Pays : United States
Organisme : NIA NIH HHS
ID : R03 AG067980
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI069494
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI069423
Pays : United States
Références
AIDS. 2022 Apr 1;36(5):637-646
pubmed: 34999609
J Infect Dis. 2017 Jan 15;215(2):228-237
pubmed: 27799351
J Clin Endocrinol Metab. 2016 Apr;101(4):1754-61
pubmed: 26900641
J Alzheimers Dis. 2014;41(1):61-8
pubmed: 24577463
Arch Intern Med. 2005 May 23;165(10):1179-84
pubmed: 15911733
Acta Med Indones. 2014 Jul;46(3):183-8
pubmed: 25348180
Gerontol Geriatr Med. 2020 Jun 15;6:2333721420924956
pubmed: 32596419
BMJ Open Diabetes Res Care. 2017 Jan 5;5(1):e000304
pubmed: 28191320
Clin Infect Dis. 2019 Jan 1;68(1):131-138
pubmed: 29788039
Sci Rep. 2015 Jan 30;5:8145
pubmed: 25634597
AIDS. 2014 Aug 24;28(13):1939-43
pubmed: 24992000
J Gerontol A Biol Sci Med Sci. 2007 Nov;62(11):1279-86
pubmed: 18000149
EBioMedicine. 2021 Mar;65:103270
pubmed: 33662832
Aging Cell. 2013 Jun;12(3):489-98
pubmed: 23521863
AIDS. 2017 Oct 23;31(16):2287-2294
pubmed: 28991026
Obesity (Silver Spring). 2019 Jul;27(7):1099-1106
pubmed: 31116012
Diabetes Care. 2000 Sep;23(9):1272-7
pubmed: 10977018
Clin Infect Dis. 2017 Jul 01;65(1):83-91
pubmed: 28369402
J Gerontol A Biol Sci Med Sci. 2001 Mar;56(3):M158-66
pubmed: 11253157
Clin Infect Dis. 2011 Dec;53(11):1130-9
pubmed: 21998280
Cell Death Dis. 2014 May 08;5:e1209
pubmed: 24810045
J Acquir Immune Defic Syndr. 2015 Dec 1;70(4):370-6
pubmed: 26102450
J Infect Dis. 2017 Mar 15;215(6):933-937
pubmed: 28453849
Acta Med Indones. 2017 Apr;49(2):118-127
pubmed: 28790226
J Alzheimers Dis. 2016;51(2):501-14
pubmed: 26890736
Exerc Sport Sci Rev. 2016 Jan;44(1):4-11
pubmed: 26583801
BMC Geriatr. 2009 Nov 19;9:49
pubmed: 19922671
Nat Med. 2015 May;21(5):506-11
pubmed: 25849133
AIDS. 2016 Nov 13;30(17):2645-2652
pubmed: 27603294
AIDS. 2018 Aug 24;32(13):1849-1860
pubmed: 29746300
Ann Fam Med. 2019 Jul;17(4):352-362
pubmed: 31285213
Aging (Albany NY). 2020 Oct 18;12(20):19852-19866
pubmed: 33071237
AIDS. 2007 Sep 12;21(14):1915-21
pubmed: 17721099
J Neurovirol. 2005 Dec;11(6):503-11
pubmed: 16338744
Endocr Metab Immune Disord Drug Targets. 2015;15(3):196-205
pubmed: 25772174
Neurology. 2019 Mar 19;92(12):e1344-e1353
pubmed: 30787163
BMC Public Health. 2006 Nov 14;6:282
pubmed: 17105659
HIV Clin Trials. 2008 Jul-Aug;9(4):269-82
pubmed: 18753121
Annu Rev Med. 2011;62:141-55
pubmed: 21090961
Diabetes Care. 2003 Dec;26(12):3257-63
pubmed: 14633811
Pathog Immun. 2020 Jun 17;5(1):143-174
pubmed: 32856008
J Clin Endocrinol Metab. 2019 Oct 1;104(10):4837-4847
pubmed: 30920623
Antivir Ther. 2018;23(2):179-190
pubmed: 28933703
J Am Geriatr Soc. 2013 May;61(5):769-75
pubmed: 23617584
Aging Cell. 2018 Aug;17(4):e12765
pubmed: 29659168
Immunity. 2013 Oct 17;39(4):633-45
pubmed: 24138880
Cell Metab. 2016 Jun 14;23(6):1060-1065
pubmed: 27304507
Aging Cell. 2019 Dec;18(6):e13039
pubmed: 31557380
J Biol Chem. 2017 May 19;292(20):8436-8446
pubmed: 28373282
J Gerontol A Biol Sci Med Sci. 2014 Oct;69(10):1299-305
pubmed: 24899525