Neurotrophins: are they involved in immune tolerance in pregnancy?
brain-derived neurotrophic factor
immune tolerance
natural killer cells
nerve growth factors
placenta
trophoblast
Journal
American journal of reproductive immunology (New York, N.Y. : 1989)
ISSN: 1600-0897
Titre abrégé: Am J Reprod Immunol
Pays: Denmark
ID NLM: 8912860
Informations de publication
Date de publication:
04 2023
04 2023
Historique:
revised:
06
01
2023
received:
29
09
2022
accepted:
08
02
2023
pubmed:
17
2
2023
medline:
15
3
2023
entrez:
16
2
2023
Statut:
ppublish
Résumé
In this review, an attempt was made to substantiate the possibility for neurotrophins to be involved in the development of immune tolerance based on data accumulated on neurotrophin content and receptor expression in the trophoblast and immune cells, in particular, in natural killer cells. Numerous research results are reviewed to show that the expression and localization of neurotrophins along with their high-affinity tyrosine kinase receptors and low-affinity p75NTR receptor in the mother-placenta-fetus system indicate the important role of neurotrophins as binding molecules in regulating the crosstalk between the nervous, endocrine, and immune systems in pregnancy. An imbalance between these systems can occur with tumor growth and pathological processes observed in pregnancy complications and fetal development anomalies.
Substances chimiques
Nerve Growth Factors
0
Brain-Derived Neurotrophic Factor
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13694Informations de copyright
© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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