Hepatic PTP4A1 ameliorates high-fat diet-induced hepatosteatosis and hyperglycemia by the activation of the CREBH/FGF21 axis.
CREBH
FGF21
PTP4A1
glucose homeostasis
hepatosteatosis
Journal
Theranostics
ISSN: 1838-7640
Titre abrégé: Theranostics
Pays: Australia
ID NLM: 101552395
Informations de publication
Date de publication:
2023
2023
Historique:
received:
30
09
2022
accepted:
18
01
2023
entrez:
16
2
2023
pubmed:
17
2
2023
medline:
18
2
2023
Statut:
epublish
Résumé
Precise regulation of kinases and phosphatases is crucial for human metabolic homeostasis. This study aimed to investigate the roles and molecular mechanisms of protein tyrosine phosphatase type IVA1 (PTP4A1) in regulating hepatosteatosis and glucose homeostasis.
Identifiants
pubmed: 36793871
doi: 10.7150/thno.79434
pii: thnov13p1076
pmc: PMC9925322
doi:
Substances chimiques
fibroblast growth factor 21
0
Cyclic AMP Response Element-Binding Protein
0
Protein Tyrosine Phosphatases
EC 3.1.3.48
Glucose
IY9XDZ35W2
PTP4A1 protein, human
EC 3.1.3.48
Membrane Proteins
0
Cell Cycle Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1076-1090Informations de copyright
© The author(s).
Déclaration de conflit d'intérêts
Competing Interests: The authors have declared that no competing interest exists.
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