Innate immune memory in cardiometabolic disease.
Atherosclerosis
Inflammation
Monocytes
Obesity
Trained immunity
Journal
Cardiovascular research
ISSN: 1755-3245
Titre abrégé: Cardiovasc Res
Pays: England
ID NLM: 0077427
Informations de publication
Date de publication:
17 02 2024
17 02 2024
Historique:
received:
04
07
2022
revised:
19
09
2022
accepted:
19
10
2022
medline:
19
2
2024
pubmed:
17
2
2023
entrez:
16
2
2023
Statut:
ppublish
Résumé
Low-grade systemic inflammation is a key pathophysiological component of atherosclerotic cardiovascular disease (CVD), and long-term activation of myeloid cells is thought to be crucial for these effects. Obesity and associated metabolic complications including hyperglycaemia and dyslipoproteinaemia can induce long-lasting inflammatory reprogramming of the innate immune cells and their bone marrow progenitors, which in turn contributes to atherosclerosis. In this review, we discuss the mechanisms through which innate immune cells undergo long-term changes in their functional, epigenetic, and metabolic characteristics upon even short-term exposure to endogenous ligands, a process also termed 'trained immunity'. Inappropriate induction of trained immunity leads to the development of long-lasting hyperinflammatory and proatherogenic changes in monocytes and macrophages, an important factor in the development of atherosclerosis and CVDs. Knowledge of the specific immune cells and the distinct intracellular molecular pathways involved in the induction of trained immunity will reveal novel pharmacological targets that could be used to prevent or treat CVDs in the future.
Identifiants
pubmed: 36795085
pii: 7043198
doi: 10.1093/cvr/cvad030
pmc: PMC10874278
doi:
Types de publication
Review
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2774-2786Subventions
Organisme : European Research Council
ID : 3310372
Pays : International
Organisme : Dutch Research Council
Pays : Netherlands
Informations de copyright
© The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology.
Déclaration de conflit d'intérêts
Conflict of interest: M.G.N. is scientif founder of TTxD and Lemba Therapeutics.
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