Exercise-induced microbial changes in preventing type 2 diabetes.

body fat diabetes gut microbiota handgrip maximum oxygen intake

Journal

Science China. Life sciences
ISSN: 1869-1889
Titre abrégé: Sci China Life Sci
Pays: China
ID NLM: 101529880

Informations de publication

Date de publication:
09 Feb 2023
Historique:
received: 08 11 2022
accepted: 10 01 2023
entrez: 16 2 2023
pubmed: 17 2 2023
medline: 17 2 2023
Statut: aheadofprint

Résumé

The metabolic benefits associated with long-term physical activity are well appreciated and growing evidence suggests that it involves the gut microbiota. Here we re-evaluated the link between exercise-induced microbial changes and those associated with prediabetes and diabetes. We found that the relative abundances of substantial amounts of diabetes-associated metagenomic species associated negatively with physical fitness in a Chinese athlete students cohort. We additionally showed that those microbial changes correlated more with handgrip strength, a simple but valuable biomarker suggestive of the diabetes states, than maximum oxygen intake, one of the key surrogates for endurance training. Moreover, the causal relationships among exercise, risks for diabetes, and gut microbiota were explored based on mediation analysis. We propose that the protective roles of exercise against type 2 diabetes are mediated, at least partly, by the gut microbiota.

Identifiants

DOI: 10.1007/s11427-022-2272-3 PMID: 36795181
pubmed: 36795181
doi: 10.1007/s11427-022-2272-3
pii: 10.1007/s11427-022-2272-3
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2023. Science China Press.

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Auteurs

Ting Yao (T)

School of Exercise and Health, Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, 200438, China.
Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi'an Jiaotong University School of Medicine, Xi'an, 710061, China.

Hui Wang (H)

Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism & Integrative Biology, Fudan University, Shanghai, 200433, China.

Kaiqing Lin (K)

School of Exercise and Health, Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, 200438, China.

Ruwen Wang (R)

School of Exercise and Health, Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, 200438, China.

Shanshan Guo (S)

School of Exercise and Health, Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, 200438, China.

Peijie Chen (P)

School of Exercise and Health, Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, 200438, China.

Hao Wu (H)

State Key Laboratory of Genetic Engineering, Human Phenome Institute, Fudan Microbiome Center, and Department of Bariatric and Metabolic Surgery, Huashan Hospital, Fudan University, Shanghai, 201203, China. hao_w@fudan.edu.cn.

Tiemin Liu (T)

School of Exercise and Health, Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, 200438, China. tiemin_liu@fudan.edu.cn.
Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism & Integrative Biology, Fudan University, Shanghai, 200433, China. tiemin_liu@fudan.edu.cn.
State Key Laboratory of Genetic Engineering, Department of Endocrinology and Metabolism, Human Phenome Institute, and School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. tiemin_liu@fudan.edu.cn.

Ru Wang (R)

School of Exercise and Health, Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, 200438, China. wangru@sus.edu.cn.

Classifications MeSH