Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition.

Humans Female Animals Prospective Studies gamma-Linolenic Acid Fatty Acids Risk Factors Diet / adverse effects Endometrial Neoplasms / epidemiology
Diet Endometrial cancer Epidemiology Fatty acids

Journal

BMC cancer
ISSN: 1471-2407
Titre abrégé: BMC Cancer
Pays: England
ID NLM: 100967800

Informations de publication

Date de publication:
16 Feb 2023
Historique:
received: 29 06 2022
accepted: 06 02 2023
entrez: 16 2 2023
pubmed: 17 2 2023
medline: 22 2 2023
Statut: epublish

Résumé

Diet may impact important risk factors for endometrial cancer such as obesity and inflammation. However, evidence on the role of specific dietary factors is limited. We investigated associations between dietary fatty acids and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). This analysis includes 1,886 incident endometrial cancer cases and 297,432 non-cases. All participants were followed up for a mean of 8.8 years. Multivariable Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) of endometrial cancer across quintiles of individual fatty acids estimated from various food sources quantified through food frequency questionnaires in the entire EPIC cohort. The false discovery rate (q-values) was computed to control for multiple comparisons. Consumption of n-6 γ-linolenic acid was inversely associated with endometrial cancer risk (HR comparing 5th with 1st quintile Our results suggest that higher consumption of γ-linolenic acid and α-linoleic acid from plant sources may be associated with lower risk of endometrial cancer.

Sections du résumé

BACKGROUND BACKGROUND
Diet may impact important risk factors for endometrial cancer such as obesity and inflammation. However, evidence on the role of specific dietary factors is limited. We investigated associations between dietary fatty acids and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC).
METHODS METHODS
This analysis includes 1,886 incident endometrial cancer cases and 297,432 non-cases. All participants were followed up for a mean of 8.8 years. Multivariable Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) of endometrial cancer across quintiles of individual fatty acids estimated from various food sources quantified through food frequency questionnaires in the entire EPIC cohort. The false discovery rate (q-values) was computed to control for multiple comparisons.
RESULTS RESULTS
Consumption of n-6 γ-linolenic acid was inversely associated with endometrial cancer risk (HR comparing 5th with 1st quintile
CONCLUSION CONCLUSIONS
Our results suggest that higher consumption of γ-linolenic acid and α-linoleic acid from plant sources may be associated with lower risk of endometrial cancer.

Identifiants

DOI: 10.1186/s12885-023-10611-0 PMID: 36797668 PMC: PMC9936701
pubmed: 36797668
doi: 10.1186/s12885-023-10611-0
pii: 10.1186/s12885-023-10611-0
pmc: PMC9936701
doi:

Substances chimiques

gamma-Linolenic Acid 78YC2MAX4O
Fatty Acids 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

159

Subventions

Organisme : Institut National Du Cancer
ID : 2016-184
Organisme : ARC
ID : 2019-DOC4

Informations de copyright

© 2023. The Author(s).

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Auteurs

S G Yammine (SG)

Université Sorbonne Paris Nord and Université Paris Cité, INSERM, INRAE, CNAM, Center of Research in Epidemiology and StatisticS (CRESS) , Nutritional Epidemiology Research Team (EREN), F-93017, Bobigny, France. sahar.yammine@eren.smbh.univ-paris13.fr.

I Huybrechts (I)

International Agency for Research on Cancer, World Health Organization, Lyon, France.

C Biessy (C)

International Agency for Research on Cancer, World Health Organization, Lyon, France.

L Dossus (L)

International Agency for Research on Cancer, World Health Organization, Lyon, France.

S Panico (S)

Dipartimento di medicina clinica e chirurgia, Federico II University, Naples, Italy.

M J Sánchez (MJ)

Escuela Andaluza de Salud Pública (EASP), Granada, Spain.
Instituto de Investigación Biosanitaria ibs. GRANADA, Granada, Spain.
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain.

V Benetou (V)

Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Grèce.

R Turzanski-Fortner (R)

The German Cancer Research Center (DKFZ), Heidelberg, Germany.

V Katzke (V)

The German Cancer Research Center (DKFZ), Heidelberg, Germany.

A Idahl (A)

Department of Clinical Sciences, Obstetrics and Gynecology, Umeå University, Umeå, Sweden.

G Skeie (G)

Faculty of Health Sciences, Department of Community Medicine, UiT The Arctic University of Norway, N - 9037, Tromsø, Norway.

K Standahl Olsen (KS)

Faculty of Health Sciences, Department of Community Medicine, UiT The Arctic University of Norway, N - 9037, Tromsø, Norway.

A Tjønneland (A)

Danish Cancer Society Research Center, Copenhagen, Denmark.
Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

J Halkjaer (J)

Danish Cancer Society Research Center, Copenhagen, Denmark.

S Colorado-Yohar (S)

Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain.
Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia.

A K Heath (AK)

Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, United Kingdom.

E Sonestedt (E)

Department of Clinical Sciences Malmö, Lund University, Sweden.

H Sartor (H)

Department of Clinical Sciences Malmö, Lund University, Sweden.

M B Schulze (MB)

Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam- Rehbruecke, Nuthetal, Germany.
Institute of Nutritional Science, University of Potsdam, Potsdam, Germany.

D Palli (D)

Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy.

M Crous-Bou (M)

Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO) - Bellvitge Biomedical Research Institute (IDIBELL). L'Hospitalet de Llobregat, 08908, Barcelona, Spain.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, 02115, Boston, MA, USA.

A Dorronsoro (A)

Ministry of Health of the Basque Government, Sub-Directorate for Public Health and Addictions of Gipuzkoa, San Sebastian, Spain.

K Overvad (K)

Department of Public Health, Aarhus University, Aarhus, Denmark.

A Barricarte Gurrea (AB)

Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
Navarra Public Health Institute, Pamplona, Spain.
Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.

G Severi (G)

Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC, Australia.
Centre for Research in Epidemiology and Population Health, INSERM U1018, Université Paris-Saclay, Villejuif, France.
Human Genetics Foundation, Turin, Italy.

R C H Vermeulen (RCH)

Julius Center for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands.
Institute for Risk Assessment Sciences (IRAS), Department of Population Health Sciences, Utrecht University, Utrecht, The Netherlands.

T M Sandanger (TM)

Faculty of Health Sciences, Department of Community Medicine, UiT The Arctic University of Norway, N - 9037, Tromsø, Norway.

R C Travis (RC)

Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.

T Key (T)

Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.

P Amiano (P)

Ministry of Health of the Basque Government, Sub-Directorate for Public Health and Addictions of Gipuzkoa, San Sebastian, Spain.

B Van Guelpen (B)

Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Wallenberg Centre for Molecular Medicine, Umeå University, Umeå, Sweden.

M Johansson (M)

International Agency for Research on Cancer, World Health Organization, Lyon, France.

M Sund (M)

Department of Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden.

R Tumino (R)

Cancer Registry and Histopathology Department, Provincial Health Authority (ASP 7), Ragusa, Italy.

N Wareham (N)

MRC Epidemiology Unit, University of Cambridge, Cambridge, England, U.K.

C Sacerdote (C)

Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital, Via Santena 7, 10126, Turin, Italy.

V Krogh (V)

Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale Dei Tumori Di, Milano, Italy.

P Brennan (P)

International Agency for Research on Cancer, World Health Organization, Lyon, France.

E Riboli (E)

Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, United Kingdom.

E Weiderpass (E)

International Agency for Research on Cancer, World Health Organization, Lyon, France.

M J Gunter (MJ)

International Agency for Research on Cancer, World Health Organization, Lyon, France.

V Chajès (V)

International Agency for Research on Cancer, World Health Organization, Lyon, France.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Dietary fatty acids and endometrial cancer...
questionsmedicales.fr › Eucaryotes › Animaux › Dietary fatty acids and endometrial cancer...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Dietary fatty acids and endometrial cancer...
questionsmedicales.fr › Lipides › Acides gras › Acides gras insaturés › Acides gras omega-6 › Acide gamma linolénique › Dietary fatty acids and endometrial cancer...
questionsmedicales.fr › Lipides › Acides gras › Dietary fatty acids and endometrial cancer...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Dietary fatty acids and endometrial cancer...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Régime alimentaire › Dietary fatty acids and endometrial cancer...
questionsmedicales.fr › Maladies urogénitales › Tumeurs de l'appareil urogénital › Tumeurs de l'appareil génital féminin › Tumeurs de l'utérus › Tumeurs de l'endomètre › Dietary fatty acids and endometrial cancer...