MS4A4A modifies the risk of Alzheimer disease by regulating lipid metabolism and immune response in a unique microglia state.

Journal

medRxiv : the preprint server for health sciences
Titre abrégé: medRxiv
Pays: United States
ID NLM: 101767986

Informations de publication

Date de publication:
08 Feb 2023
Historique:
pubmed: 18 2 2023
medline: 18 2 2023
entrez: 17 2 2023
Statut: epublish

Résumé

Genome-wide association studies (GWAS) have identified many modifiers of Alzheimer disease (AD) risk enriched in microglia. Two of these modifiers are common variants in the

Identifiants

DOI: 10.1101/2023.02.06.23285545 PMID: 36798226 PMC: PMC9934804
pubmed: 36798226
doi: 10.1101/2023.02.06.23285545
pmc: PMC9934804
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NIA NIH HHS
ID : R56 AG067764
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG062734
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG058501
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS127211
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS118146
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG032438
Pays : United States

Auteurs

Shih-Feng You (SF)

Department of Psychiatry, Washington University in St. Louis School of Medicine, USA.

Logan Brase (L)

Department of Psychiatry, Washington University in St. Louis School of Medicine, USA.

Fabia Filipello (F)

Department of Psychiatry, Washington University in St. Louis School of Medicine, USA.

Abhirami K Iyer (AK)

Department of Psychiatry, Washington University in St. Louis School of Medicine, USA.

Jorge Del-Aguila (J)

Department of Psychiatry, Washington University in St. Louis School of Medicine, USA.

June He (J)

Department of Psychiatry, Washington University in St. Louis School of Medicine, USA.

Ricardo D'Oliveira Albanus (R)

Department of Psychiatry, Washington University in St. Louis School of Medicine, USA.

John Budde (J)

Department of Psychiatry, Washington University in St. Louis School of Medicine, USA.

Joanne Norton (J)

Department of Psychiatry, Washington University in St. Louis School of Medicine, USA.

Jen Gentsch (J)

Department of Psychiatry, Washington University in St. Louis School of Medicine, USA.

Nina M Dräger (NM)

Institute for Neurodegenerative Diseases, Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.

Sydney M Sattler (SM)

Institute for Neurodegenerative Diseases, Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.

Martin Kampmann (M)

Institute for Neurodegenerative Diseases, Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.

Laura Piccio (L)

Department of Psychiatry, Washington University in St. Louis School of Medicine, USA.
Charles Perkins Centre and Brain and Mind Centre, School of Medical Sciences, University of Sydney, Sydney, NSW, Australia.

John C Morris (JC)

Department of Neurology, Washington University in St. Louis School of Medicine, USA.
The Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, Missouri, USA.

Richard J Perrin (RJ)

Department of Neurology, Washington University in St. Louis School of Medicine, USA.
The Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, Missouri, USA.
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.

Eric McDade (E)

Department of Neurology, Washington University in St. Louis School of Medicine, USA.

Steven M Paul (SM)

Department of Psychiatry, Washington University in St. Louis School of Medicine, USA.

Anil G Cashikar (AG)

Department of Psychiatry, Washington University in St. Louis School of Medicine, USA.

Bruno A Benitez (BA)

Department of Neurology, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.

Oscar Harari (O)

Department of Psychiatry, Washington University in St. Louis School of Medicine, USA.
The Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, Missouri, USA.

Celeste M Karch (CM)

Department of Psychiatry, Washington University in St. Louis School of Medicine, USA.
The Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, Missouri, USA.
NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, Missouri, USA.

Classifications MeSH