The BAF chromatin complex component SMARCC1 does not mediate GLI transcriptional repression of Hedgehog target genes in limb buds.
Journal
bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187
Informations de publication
Date de publication:
17 Jul 2023
17 Jul 2023
Historique:
pubmed:
18
2
2023
medline:
18
2
2023
entrez:
17
2
2023
Statut:
epublish
Résumé
Transcriptional responses to the Hedgehog (HH) signaling pathway are primarily modulated by GLI repression in the mouse limb. Previous studies suggested a role for the BAF chromatin remodeling complex in mediating GLI repression. Consistent with this possibility, the core BAF complex protein SMARCC1 is present at most active limb enhancers including the majority of GLI enhancers. However, in contrast to GLI repression which reduces chromatin accessibility, SMARCC1 maintains chromatin accessibility at most enhancers, including those bound by GLI. Moreover, SMARCC1 binding at GLI-regulated enhancers occurs independently of GLI3. Consistent with previous studies, some individual GLI target genes are mis-regulated in
Identifiants
pubmed: 36798239
doi: 10.1101/2023.02.03.527038
pmc: PMC9934545
pii:
doi:
Types de publication
Preprint
Langues
eng
Subventions
Organisme : NIDCR NIH HHS
ID : F31 DE027597
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD073151
Pays : United States
Commentaires et corrections
Type : UpdateIn
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