ApoE Alzheimer's Disease Aβ-amyloid plaque morphology varies according to APOE isotype.
Alzheimer’s disease (AD)
Cerebral amyloid angiopathy (CAA)
apolipoprotein E (APOE, gene; apoE, protein)
hyperspectral fluorescence imaging
luminescent conjugated oligothiophene (LCO)
neurofibrillary tangle (NFT)
plaque
Journal
Research square
Titre abrégé: Res Sq
Pays: United States
ID NLM: 101768035
Informations de publication
Date de publication:
08 Feb 2023
08 Feb 2023
Historique:
pubmed:
18
2
2023
medline:
18
2
2023
entrez:
17
2
2023
Statut:
epublish
Résumé
The apolipoprotein E ( We have employed hyperspectral fluorescence imaging with an amyloidspecific, conformation-sensing probe, p-FTAA, to elucidate protein aggregate structure and morphology in fresh frozen prefrontal cortex samples from human postmortem AD brain tissue samples from patients homozygous for either As expected These data support the hypothesis that one mechanism by which the
Sections du résumé
Background
UNASSIGNED
The apolipoprotein E (
Methods
UNASSIGNED
We have employed hyperspectral fluorescence imaging with an amyloidspecific, conformation-sensing probe, p-FTAA, to elucidate protein aggregate structure and morphology in fresh frozen prefrontal cortex samples from human postmortem AD brain tissue samples from patients homozygous for either
Results
UNASSIGNED
As expected
Conclusions
UNASSIGNED
These data support the hypothesis that one mechanism by which the
Identifiants
pubmed: 36798327
doi: 10.21203/rs.3.rs-2524641/v1
pmc: PMC9934766
pii:
doi:
Types de publication
Preprint
Langues
eng