The mechanosensitive ion channel Piezo1 modulates the migration and immune response of microglia.
Cell biology
Immunology
Molecular neuroscience
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
17 Feb 2023
17 Feb 2023
Historique:
received:
20
08
2022
revised:
28
11
2022
accepted:
12
01
2023
entrez:
17
2
2023
pubmed:
18
2
2023
medline:
18
2
2023
Statut:
epublish
Résumé
Microglia are the brain's resident immune cells, performing surveillance to promote homeostasis and healthy functioning. While microglial chemical signaling is well-studied, mechanical cues regulating their function are less well-understood. Here, we investigate the role of the mechanosensitive ion channel Piezo1 in microglia migration, pro-inflammatory cytokine production, and stiffness sensing. In Piezo1 knockout transgenic mice, we demonstrated the functional expression of Piezo1 in microglia and identified genes whose expression was consequently affected. Functional assays revealed that Piezo1 deficiency in microglia enhanced migration toward amyloid β-protein, and decreased levels of pro-inflammatory cytokines produced upon stimulation by lipopolysaccharide, both
Identifiants
pubmed: 36798430
doi: 10.1016/j.isci.2023.105993
pii: S2589-0042(23)00070-6
pmc: PMC9926228
doi:
Types de publication
Journal Article
Langues
eng
Pagination
105993Informations de copyright
© 2023 The Author(s).
Déclaration de conflit d'intérêts
The authors declare no competing interests.
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