Protective effects of melatonin against physical injuries to testicular tissue: A systematic review and meta-analysis of animal models.
heat
infertility
ischemia
melatonin
oxidative stress
reperfusion
rodents
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2023
2023
Historique:
received:
14
12
2022
accepted:
17
01
2023
entrez:
17
2
2023
pubmed:
18
2
2023
medline:
22
2
2023
Statut:
epublish
Résumé
Modern societies face infertility as a global challenge. There are certain environmental conditions and disorders that damage testicular tissue and may cause male infertility. Melatonin, as a potential antioxidant, may protect testicular tissue. Therefore, we conducted this systematic review and meta-analysis to evaluate the effects of melatonin in animal models against physical, heat, and ischemic damage to the testicular tissue. PubMed, Scopus, and Web of Science were systematically searched to identify animal trials evaluating the protective effect of melatonin therapy on rodent testicular tissue when it is exposed to physical, thermal, ischemic, or hypobaric oxygen stress. Random-effect modeling was used to estimate the standardized mean difference and 95% confidence intervals based on the pooled data. Additionally, the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) tool was used to assess the risk of bias. The study protocol was prospectively registered in PROSPERO (CRD42022354599). A total of 41 studies were eligible for review out of 10039 records. Studies employed direct heat, cryptorchidism, varicocele, torsion-detorsion, testicular vascular occlusion, hypobaric hypoxia, ischemia-reperfusion, stress by excessive or restraint activity, spinal cord injury, and trauma to induce stress in the subjects. The histopathological characteristics of testicular tissue were generally improved in rodents by melatonin therapy. Based on the pooled data, sperm count, morphology, forward motility, viability, Johnsen's biopsy score, testicular tissue glutathione peroxidase, and superoxide dismutase levels were higher in the melatonin treatment rodent arms. In contrast, the malondialdehyde level in testicular tissue was lower in the treatment rodent arms. The included studies suffered from a high risk of bias in most of the SYRCLE domains. This study concludes that melatonin therapy was associated with improved testicular histopathological characteristics, reproductive hormonal panel, and tissue markers of oxidative stress in male rodents with physical, ischemic, and thermal testicular injuries. In this regard, melatonin deserves scientific investigations as a potential protective drug against rodent male infertility. https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42022354599.
Sections du résumé
Background
Modern societies face infertility as a global challenge. There are certain environmental conditions and disorders that damage testicular tissue and may cause male infertility. Melatonin, as a potential antioxidant, may protect testicular tissue. Therefore, we conducted this systematic review and meta-analysis to evaluate the effects of melatonin in animal models against physical, heat, and ischemic damage to the testicular tissue.
Methods
PubMed, Scopus, and Web of Science were systematically searched to identify animal trials evaluating the protective effect of melatonin therapy on rodent testicular tissue when it is exposed to physical, thermal, ischemic, or hypobaric oxygen stress. Random-effect modeling was used to estimate the standardized mean difference and 95% confidence intervals based on the pooled data. Additionally, the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) tool was used to assess the risk of bias. The study protocol was prospectively registered in PROSPERO (CRD42022354599).
Results
A total of 41 studies were eligible for review out of 10039 records. Studies employed direct heat, cryptorchidism, varicocele, torsion-detorsion, testicular vascular occlusion, hypobaric hypoxia, ischemia-reperfusion, stress by excessive or restraint activity, spinal cord injury, and trauma to induce stress in the subjects. The histopathological characteristics of testicular tissue were generally improved in rodents by melatonin therapy. Based on the pooled data, sperm count, morphology, forward motility, viability, Johnsen's biopsy score, testicular tissue glutathione peroxidase, and superoxide dismutase levels were higher in the melatonin treatment rodent arms. In contrast, the malondialdehyde level in testicular tissue was lower in the treatment rodent arms. The included studies suffered from a high risk of bias in most of the SYRCLE domains.
Conclusion
This study concludes that melatonin therapy was associated with improved testicular histopathological characteristics, reproductive hormonal panel, and tissue markers of oxidative stress in male rodents with physical, ischemic, and thermal testicular injuries. In this regard, melatonin deserves scientific investigations as a potential protective drug against rodent male infertility.
Systematic review registration
https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42022354599.
Identifiants
pubmed: 36798664
doi: 10.3389/fendo.2023.1123999
pmc: PMC9927015
doi:
Substances chimiques
Melatonin
JL5DK93RCL
Types de publication
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1123999Informations de copyright
Copyright © 2023 Dehdari Ebrahimi, Shojaei-Zarghani, Taherifard, Dastghaib, Parsa, Mohammadi, Sabet Sarvestani, Moayedfard, Hosseini, Safarpour, Sadeghi, Azarpira and Safarpour.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Zygote. 2010 Aug;18(3):257-64
pubmed: 20109269
J Pediatr Surg. 2009 Sep;44(9):1754-8
pubmed: 19735821
Reprod Biol Endocrinol. 2014 May 07;12:33
pubmed: 24885775
Andrologia. 2018 Apr;50(3):
pubmed: 29044638
Annu Rev Pharmacol Toxicol. 2016;56:361-83
pubmed: 26514204
Biochem Pharmacol. 2022 Dec;206:115265
pubmed: 36183803
Molecules. 2018 Feb 24;23(2):
pubmed: 29495303
Control Clin Trials. 1986 Sep;7(3):177-88
pubmed: 3802833
Tissue Cell. 2022 Dec;79:101904
pubmed: 36058048
J Biomed Sci. 2015 Jul 24;22:61
pubmed: 26205951
Nig Q J Hosp Med. 2008 Jul-Sep;18(3):149-52
pubmed: 19062479
Endocr Rev. 2009 Apr;30(2):119-32
pubmed: 19176467
Front Endocrinol (Lausanne). 2022 Oct 11;13:1022989
pubmed: 36303864
Free Radic Res. 2020 Jan;54(1):1-26
pubmed: 31868060
Stem Cell Res Ther. 2021 Jun 29;12(1):370
pubmed: 34187560
J Pineal Res. 2004 Jan;36(1):1-9
pubmed: 14675124
Saudi Med J. 2007 Feb;28(2):288-9
pubmed: 17268715
J Pediatr Urol. 2016 Dec;12(6):410.e1-410.e7
pubmed: 27595505
Neuro Endocrinol Lett. 2003 Jun-Aug;24(3-4):170-2
pubmed: 14523352
Exp Ther Med. 2020 Jul;20(1):235-242
pubmed: 32509010
Fertil Steril. 2006 Aug;86(2):332-8
pubmed: 16764873
Front Endocrinol (Lausanne). 2022 Aug 03;13:895095
pubmed: 35992124
Biomed Pharmacother. 2021 Jun;138:111481
pubmed: 33752059
Toxicol Lett. 2019 Jun 15;308:24-33
pubmed: 30910607
Eur Rev Med Pharmacol Sci. 2012 May;16(5):582-8
pubmed: 22774397
Biochem J. 2011 Jun 15;436(3):687-98
pubmed: 21470189
Fertil Steril. 2014 Dec;102(6):1518-27
pubmed: 25458618
Endocrine. 2010 Jun;37(3):479-88
pubmed: 20960172
BMJ. 2021 Mar 29;372:n71
pubmed: 33782057
Acta Med Iran. 2014;52(7):496-504
pubmed: 25135257
West Afr J Med. 2007 Oct-Dec;26(4):312-5
pubmed: 18705433
Drug Metab Dispos. 2005 Apr;33(4):489-94
pubmed: 15616152
Sci Rep. 2017 Aug 29;7(1):9599
pubmed: 28851995
Fertil Steril. 2010 Mar 15;93(5):1545-9
pubmed: 19328481
Urology. 2012 Oct;80(4):899-906
pubmed: 22950989
Mol Cell Endocrinol. 2012 Apr 4;351(2):152-66
pubmed: 22245784
Zhonghua Nan Ke Xue. 2019 Apr;25(5):309-314
pubmed: 32216211
J Pediatr Surg. 2017 Apr;52(4):582-586
pubmed: 27899171
Fertil Steril. 2008 May;89(5 Suppl):1468-73
pubmed: 17681337
Int J Gen Med. 2020 Feb 05;13:29-41
pubmed: 32104049
Syst Biol Reprod Med. 2017 Dec;63(6):370-381
pubmed: 28846448
J Pediatr Surg. 2008 Oct;43(10):1873-8
pubmed: 18926224
J Pharm Pharmacol. 2018 Mar;70(3):291-306
pubmed: 29168173
Neurobiol Dis. 2013 Jul;55:26-35
pubmed: 23537713
Braz J Med Biol Res. 2009 Jul;42(7):621-8
pubmed: 19578641
Neuro Endocrinol Lett. 2003 Feb-Apr;24(1-2):86-90
pubmed: 12743540
J Pediatr Surg. 2004 Aug;39(8):1238-41
pubmed: 15300535
Urol Res. 2004 Jun;32(3):204-8
pubmed: 15205854
Front Physiol. 2014 Oct 06;5:377
pubmed: 25339906
Asian J Androl. 2014 Mar-Apr;16(2):314-8
pubmed: 24407181
Exp Mol Pathol. 2010 Dec;89(3):314-20
pubmed: 20670623
Biopreserv Biobank. 2022 Aug;20(4):374-383
pubmed: 35984941
World J Mens Health. 2014 Apr;32(1):1-17
pubmed: 24872947
J Urol. 2010 Aug;184(2):790-6
pubmed: 20639057
J Urol. 2004 Jan;171(1):501-3
pubmed: 14665963
Molecules. 2018 Feb 17;23(2):
pubmed: 29462985
J Exp Bot. 2022 Jan 27;73(3):727-741
pubmed: 34652437
Andrologia. 2017 Sep;49(7):
pubmed: 27595881
Folia Med (Plovdiv). 2022 Feb 28;64(1):75-83
pubmed: 35851886
Biochem Soc Trans. 2015 Aug;43(4):621-6
pubmed: 26551702
Res Pharm Sci. 2019 Jun;14(3):201-208
pubmed: 31160897
Biology (Basel). 2021 Mar 20;10(3):
pubmed: 33804600
Int J Reprod Biomed. 2017 Mar;15(3):141-146
pubmed: 28580446
Biol Reprod. 2021 Jun 4;104(6):1322-1336
pubmed: 33709108
Stem Cell Res Ther. 2017 Oct 17;8(1):233
pubmed: 29041987
Pharmacol Res. 2020 Nov;161:105210
pubmed: 33007423
Asian J Androl. 2015 Jul-Aug;17(4):633-9
pubmed: 25999358
Int J Endocrinol. 2012;2012:637825
pubmed: 22315592
Cell Tissue Res. 2018 Apr;372(1):149-159
pubmed: 29196809
Cochrane Database Syst Rev. 2019 Oct 3;10:ED000142
pubmed: 31643080
Zool Res. 2021 Jul 18;42(4):514-524
pubmed: 34254745
Chem Biol Interact. 2008 Nov 25;176(2-3):121-8
pubmed: 18723006
Animals (Basel). 2021 May 12;11(5):
pubmed: 34066291
Biol Res. 2011;44(2):161-7
pubmed: 22513419
Br J Pharmacol. 2016 Sep;173(18):2702-25
pubmed: 27314810
Reprod Biol Endocrinol. 2022 Jul 18;20(1):105
pubmed: 35850689
Drug Discov Today. 2014 Sep;19(9):1410-8
pubmed: 24792719
Theriogenology. 2018 Jan 15;106:170-177
pubmed: 29073541
Life (Basel). 2022 Mar 30;12(4):
pubmed: 35455002
Urol J. 2018 Nov 17;15(6):387-396
pubmed: 30178446
Vitam Horm. 2023;121:197-246
pubmed: 36707135
Neuroendocrinology. 2022;112(2):115-129
pubmed: 33774638
Br J Pharmacol. 2022 Jul;179(13):3363-3381
pubmed: 35064582
Andrologia. 2002 Dec;34(6):391-6
pubmed: 12472624
Curr Mol Med. 2015;15(4):299-311
pubmed: 25941822
Syst Rev. 2016 Dec 5;5(1):210
pubmed: 27919275
Biomed Pharmacother. 2018 Dec;108:515-523
pubmed: 30243084
BMC Med Res Methodol. 2014 Mar 26;14:43
pubmed: 24667063
Anim Reprod Sci. 2014 Jun 10;147(1-2):10-6
pubmed: 24768045
World J Mens Health. 2021 Oct;39(4):760-775
pubmed: 33663027
Biomol Ther (Seoul). 2023 Jan 1;31(1):97-107
pubmed: 36097885
Mol Hum Reprod. 2020 Feb 29;26(2):65-79
pubmed: 31943111
Fertil Steril. 2011 Jun;95(7):2290-6
pubmed: 21497337
Andrologia. 2018 Aug;50(6):e13033
pubmed: 29740842
J Pineal Res. 2016 Oct;61(3):253-78
pubmed: 27500468
Biochem Genet. 2017 Dec;55(5-6):395-409
pubmed: 29094225
J Pineal Res. 2010 Sep;49(2):149-55
pubmed: 20524970
Curr Res Physiol. 2021 Mar 27;4:119-124
pubmed: 34746831
Cell Mol Life Sci. 2017 Nov;74(21):3863-3881
pubmed: 28864909
Curr Neuropharmacol. 2010 Sep;8(3):194-210
pubmed: 21358970
Reprod Toxicol. 2022 Oct;113:18-29
pubmed: 35952901
Fundam Clin Pharmacol. 2005 Jun;19(3):365-72
pubmed: 15910661
Cryobiology. 2020 Aug;95:1-8
pubmed: 32001217
Fertil Steril. 2007 Jul;88(1):188-92
pubmed: 17307171