On the interdependence of ketone body oxidation, glycogen content, glycolysis and energy metabolism in the heart.


Journal

The Journal of physiology
ISSN: 1469-7793
Titre abrégé: J Physiol
Pays: England
ID NLM: 0266262

Informations de publication

Date de publication:
04 2023
Historique:
received: 14 12 2022
accepted: 23 01 2023
medline: 3 4 2023
pubmed: 18 2 2023
entrez: 17 2 2023
Statut: ppublish

Résumé

In heart, glucose and glycolysis are important for anaplerosis and potentially therefore for d-β-hydroxybutyrate (βHB) oxidation. As a glucose store, glycogen may also furnish anaplerosis. We determined the effects of glycogen content on βHB oxidation and glycolytic rates, and their downstream effects on energetics, in the isolated rat heart. High glycogen (HG) and low glycogen (LG) containing hearts were perfused with 11 mM [5-

Identifiants

pubmed: 36799478
doi: 10.1113/JP284270
pmc: PMC10684314
doi:

Substances chimiques

NAD 0U46U6E8UK
Glycogen 9005-79-2
3-Hydroxybutyric Acid TZP1275679
Ketone Bodies 0
Glucose IY9XDZ35W2
Adenosine Triphosphate 8L70Q75FXE

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1207-1224

Commentaires et corrections

Type : CommentIn

Informations de copyright

© 2023 The Authors. The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society.

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Auteurs

Azrul Abdul Kadir (AA)

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.

Brianna J Stubbs (BJ)

Buck Institute for Research on Aging, Novato, CA, USA.

Cher-Rin Chong (CR)

Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, Australia.

Henry Lee (H)

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.

Mark Cole (M)

School of Life Sciences, University of Nottingham, Nottingham, UK.

Carolyn Carr (C)

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.

David Hauton (D)

Department of Chemistry, University of Oxford, Oxford, UK.

James McCullagh (J)

Department of Chemistry, University of Oxford, Oxford, UK.

Rhys D Evans (RD)

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.

Kieran Clarke (K)

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.

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