[New models to study human embryonic development].
Du nouveau dans les modèles d’étude de l’embryon humain.
Journal
Medecine sciences : M/S
ISSN: 1958-5381
Titre abrégé: Med Sci (Paris)
Pays: France
ID NLM: 8710980
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
entrez:
17
2
2023
pubmed:
18
2
2023
medline:
22
2
2023
Statut:
ppublish
Résumé
Since 2021, assisted reproductive technologies (ART) are available to infertile couples, but also to single women and female couples. The process of in vitro fertilization (IVF) has allowed to cross the threshold of 5 million births worldwide, between 1978 and 2013. However, the failure rate per each IVF cycle is estimated to be around 75%. Therefore, there is a need to better understand human embryonic development in order to improve the success rate of IVF. Study models have evolved significantly in recent years: development of embryo culture, sequencing of the transcriptome of individualized cells, discovery of culture conditions for naive pluripotent stem cells and generation of blastoids. Here, we review these recent advances in human embryo modeling that establish a new knowledge base for improving ART. Du nouveau dans les modèles d’étude de l’embryon humain. Depuis 2021, l’assistance médicale à la procréation (AMP) est accessible aux couples infertiles, mais aussi aux femmes seules et aux couples de femmes. Le processus de fécondation in vitro (FIV) a permis de franchir le seuil de cinq millions de naissances dans le monde, entre 1978 et 2013. Cependant, le taux d’échec à chaque cycle est évalué à environ 75 %. Il est donc nécessaire de mieux comprendre le développement embryonnaire humain afin d’améliorer le taux de succès des FIV. Les modèles d’étude ont beaucoup évolué ces dernières années : mise au point de la culture embryonnaire, séquençage du transcriptome de cellules individualisées, découverte des conditions de culture de cellules souches pluripotentes naïves et génération de blastoïdes. Nous revenons dans cette revue sur ces avancées récentes concernant la modélisation de l’embryon humain, qui établissent un nouveau socle de connaissances pour améliorer l’AMP.
Autres résumés
Type: Publisher
(fre)
Du nouveau dans les modèles d’étude de l’embryon humain.
Identifiants
pubmed: 36799747
doi: 10.1051/medsci/2023018
pii: msc220234
doi:
Types de publication
Review
English Abstract
Journal Article
Langues
fre
Sous-ensembles de citation
IM
Pagination
129-136Informations de copyright
© 2023 médecine/sciences – Inserm.
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