Social determinants and distance from certified treatment centers are associated with initiation of esketamine nasal spray among patients with challenging-to-treat major depressive disorder.
Journal
Medicine
ISSN: 1536-5964
Titre abrégé: Medicine (Baltimore)
Pays: United States
ID NLM: 2985248R
Informations de publication
Date de publication:
17 Feb 2023
17 Feb 2023
Historique:
entrez:
17
2
2023
pubmed:
18
2
2023
medline:
22
2
2023
Statut:
ppublish
Résumé
Indicated for treatment-resistant depression or major depression with suicidal ideation, esketamine (ESK) is self-administered under supervision at certified treatment centers. Our study was to determine if social determinants of health and distance were associated with ESK utilization. We conducted a retrospective cohort study among 308 US adults initiating ESK between October 11, 2019 and December 31, 2020 and 1540 propensity-score matched controls with treatment-resistant depression or major depression with suicidal ideation. Adjusting for demographics, prior health care utilization and comorbidities, social determinant variables and distance were regressed separately on each outcome: ESK initiation, failure to complete induction (8 treatments in 45 days), and discontinuation within 6 months. ESK initiation was associated with higher population density (odds ratio [OR]: 2.12), American Indian, Alaska Native, Native Hawaiian, Other Pacific Islander (OR: 3.19), and mental health (OR: 1.55) and primary care providers (OR: 1.55) per capita. Lower likelihood of ESK initiation was associated with living > 7.2 miles from a treatment center (OR: 0.75), living in rural areas (OR: 0.64), and percent non-Hispanic African American (OR: 0.58) and Hispanic (OR: 0.40). Health care providers should tailor patient engagement strategies to mitigate potential barriers to initiating and continuing appropriate treatment. Failing to complete induction was associated with substance use disorder and longer distance to treatment center was associated with discontinuation (hazard ratio: 1.48), as was percent Asian population (hazard ratio: 1.37). Prior psychiatric care and residence in counties with high rates of primary care providers per capita, unemployment, and high school graduation were associated with both higher likelihood of completing induction and lower likelihood of discontinuation.
Identifiants
pubmed: 36800597
doi: 10.1097/MD.0000000000032895
pii: 00005792-202302170-00028
pmc: PMC9935983
doi:
Substances chimiques
Nasal Sprays
0
Esketamine
50LFG02TXD
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e32895Informations de copyright
Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.
Références
Kessler RC, Barber C, Birnbaum HG, et al. Depression in the workplace: effects on short-term disability. Health Aff (Millwood). 1999;18:163–71.
Mancuso CA, Peterson MG, Charlson ME. Effects of depressive symptoms on health-related quality of life in asthma patients. J Gen Intern Med. 2000;15:301–10.
Ruo B, Rumsfeld JS, Hlatky MA, et al. Depressive symptoms and health-related quality of life: the heart and soul study. JAMA. 2003;290:215–21.
Frojd SA, Nissinen ES, Pelkonen MU, et al. Depression and school performance in middle adolescent boys and girls. J Adolesc. 2008;31:485–98.
Cai H, Jin Y, Liu S, et al. Prevalence of suicidal ideation and planning in patients with major depressive disorder: a meta-analysis of observation studies. J Affect Disord. 2021;293:148–58.
Hiranyatheb T, Nakawiro D, Wongpakaran T, et al. The impact of residual symptoms on relapse and quality of life among Thai depressive patients. Neuropsychiatr Dis Treat. 2016;12:3175–81.
Nil R, Lutolf S, Seifritz E. Residual symptoms and functionality in depressed outpatients: a one-year observational study in Switzerland with escitalopram. J Affect Disord. 2016;197:245–50.
Pigott HE, Leventhal AM, Alter GS, et al. Efficacy and effectiveness of antidepressants: current status of research. Psychother Psychosom. 2010;79:267–79.
Zhdanava M, Pilon D, Ghelerter I, et al. The prevalence and national burden of treatment-resistant depression and major depressive disorder in the United States. J Clin Psychiatry. 2021;82:20m13699.
Le Cook B, Trinh NH, Li Z, et al. Trends in racial-ethnic disparities in access to mental health care, 2004-2012. Psychiatr Serv. 2017;68:9–16.
Le Cook B, Zuvekas SH, Carson N, et al. Assessing racial/ethnic disparities in treatment across episodes of mental health care. Health Serv Res. 2014;49:206–29.
Jones AL, Cochran SD, Leibowitz A, et al. Racial, ethnic, and nativity differences in mental health visits to primary care and specialty mental health providers: analysis of the medical expenditures panel survey, 2010-2015. Health care (Basel). 2018;6:29.
Lee SY, Xue QL, Spira AP, et al. Racial and ethnic differences in depressive subtypes and access to mental health care in the United States. J Affect Disord. 2014;155:130–7.
Munasinghe S, Page A, Mannan H, et al. Determinants of treatment non-attendance among those referred to primary mental health care services in Western Sydney, Australia: a retrospective cohort study. BMJ Open. 2020;10:e039858.
Munasinghe S, Page A, Mannan H, et al. Determinants of treatment disengagement among those at risk of suicide referred to primary mental health care services in Western Sydney, Australia. Aust N Z J Psychiatry. 2021;55:277–88.
Sentell T, Shumway M, Snowden L. Access to mental health treatment by English language proficiency and race/ethnicity. J Gen Intern Med. 2007;22(Suppl 2):289–93.
Packness A, Halling A, Simonsen E, et al. Are perceived barriers to accessing mental health care associated with socioeconomic position among individuals with symptoms of depression? questionnaire-results from the Lolland-Falster health study, a rural Danish population study. BMJ Open. 2019;9:e023844.
Kelly C, Hulme C, Farragher T, et al. Are differences in travel time or distance to health care for adults in global north countries associated with an impact on health outcomes? a systematic review. BMJ Open. 2016;6:e013059.
Murphy J, Elliot M, Ravindrarajah R, et al. Investigating the impact of distance on the use of primary care extended hours. Int J Popul Data Sci. 2021;6:1401.
Lubloy A. Factors affecting the uptake of new medicines: a systematic literature review. BMC Health Serv Res. 2014;14:469.
SPRAVATO™ (Esketamine) Nasal Spray [Package Insert]. Lakewood, NJ: Renaissance Lakewood LLC. 2019.
American Psychiatric Association. Practice guidelines for the treatment of major depressive disorder. 2010. Available at: https://psychiatryonline.org/pb/assets/raw/sitewide/practice_guidelines/guidelines/mdd.pdf . [Access date August 1, 2019].
Amos T, Tandon N, Lefebvre P, et al. Direct and indirect cost burden and change of employment status in treatment-resistant depression: a matched-cohort study using a U.S. commercial claims database. J Clin Psychiatry. 2018;79:17m11725.
Breslau J, Cefalu M, Wong EC, et al. Racial/ethnic differences in perception of need for mental health treatment in a US national sample. Soc Psychiatry Psychiatr Epidemiol. 2017;52:929–37.
Green JG, McLaughlin KA, Fillbrunn M, et al. Barriers to mental health service use and predictors of treatment drop out: racial/ethnic variation in a population-based study. Adm Policy Ment Health. 2020;47:606–16.
Breslau J, Wong EC, Burnam MA, et al. Distress, impairment, and racial/ethnic differences in perceived need for mental health treatment in a nationally representative sample. Psychiatry. 2020;83:149–60.
Augsberger A, Yeung A, Dougher M, et al. Factors influencing the underutilization of mental health services among Asian American women with a history of depression and suicide. BMC Health Serv Res. 2015;15:542.
Yang KG, Rodgers CRR, Lee E, et al. Disparities in mental health care utilization and perceived need among Asian Americans: 2012-2016. Psychiatr Serv. 2020;71:21–7.
Hines AL, Cooper LA, Shi L. Racial and ethnic differences in mental health care utilization consistent with potentially effective care: the role of patient preferences. Gen Hosp Psychiatry. 2017;46:14–9.
Nordbo EC, Nordh H, Raanaas RK, et al. GIS-derived measures of the built environment determinants of mental health and activity participation in childhood and adolescence: a systematic review. Landsc Urban Plan. 2018;177:19–37.
Evans GW. The built environment and mental health. J Urban Health. 2003;80:536–55.
Renalds A, Smith TH, Hale PJ. A systematic review of built environment and health. Fam Community Health. 2010;33:68–78.
McCarthy JF, Blow FC. Older patients with serious mental illness: sensitivity to distance barriers for outpatient care. Med Care. 2004;42:1073–80.
Packness A, Waldorff FB, Christensen RD, et al. Impact of socioeconomic position and distance on mental health care utilization: a nationwide Danish follow-up study. Soc Psychiatry Psychiatr Epidemiol. 2017;52:1405–13.
Upadhyay N, Aparasu R, Rowan PJ, et al. The association between geographic access to providers and the treatment quality of pediatric depression. J Affect Disord. 2019;253:162–70.
Cummings JR, Allen L, Clennon J, et al. Geographic access to specialty mental health care across high- and low income US communities. JAMA Psychiatry. 2017;74:476–84.
Hasin DS, Sarvet AL, Meyers JL, et al. Epidemiology of adult DSM-5 major depressive disorder and its specifiers in the United States. JAMA Psychiatry. 2018;75:336–46.
Kim EJ, Abrahams S, Uwemedimo O, et al. Prevalence of social determinants of health and associations of social needs among United States adults, 2011-2014. J Gen Intern Med. 2020;35:1608–9.
Sorkin DH, Nguyen H, Ngo-Metzger Q. Assessing the mental health needs and barriers to care among a diverse sample of Asian American older adults. J Gen Intern Med. 2011;26:595–602.
Voelker J, Cai Q, Daly E, et al. Mental health care resource utilization and barriers to receiving mental health services among US adults with a major depressive episode and suicidal ideation or behavior with intent. J Clin Psychiatry. 2021;82:20m13842.
Fortney J, Rost K, Zhang M, et al. The impact of geographic accessibility on the intensity and quality of depression treatment. Med Care. 1999;37:884–93.