Inhomogeneous mechanotransduction defines the spatial pattern of apoptosis-induced compensatory proliferation.
YAP
apoptosis
cell division
compensatory proliferation
mechanotransduction
tissue homeostasis
Journal
Developmental cell
ISSN: 1878-1551
Titre abrégé: Dev Cell
Pays: United States
ID NLM: 101120028
Informations de publication
Date de publication:
27 02 2023
27 02 2023
Historique:
received:
20
09
2021
revised:
09
07
2022
accepted:
26
01
2023
pubmed:
22
2
2023
medline:
3
3
2023
entrez:
21
2
2023
Statut:
ppublish
Résumé
The number of cells in tissues is controlled by cell division and cell death, and its misregulation could lead to pathological conditions such as cancer. To maintain the cell numbers, a cell-elimination process called apoptosis also stimulates the proliferation of neighboring cells. This mechanism, apoptosis-induced compensatory proliferation, was originally described more than 40 years ago. Although only a limited number of the neighboring cells need to divide to compensate for the apoptotic cell loss, the mechanisms that select cells to divide have remained elusive. Here, we found that spatial inhomogeneity in Yes-associated protein (YAP)-mediated mechanotransduction in neighboring tissues determines the inhomogeneity of compensatory proliferation in Madin-Darby canine kidney (MDCK) cells. Such inhomogeneity arises from the non-uniform distribution of nuclear size and the non-uniform pattern of mechanical force applied to neighboring cells. Our findings from a mechanical perspective provide additional insight into how tissues precisely maintain homeostasis.
Identifiants
pubmed: 36800994
pii: S1534-5807(23)00036-9
doi: 10.1016/j.devcel.2023.01.005
pmc: PMC7614677
mid: EMS177290
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
267-277.e5Subventions
Organisme : European Research Council
ID : 101019835
Pays : International
Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
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