Ionic mononuclear [Fe] and heterodinuclear [Fe,Ru] bis(diphenylphosphino)alkane complexes: Synthesis, spectroscopy, DFT structures, cytotoxicity, and biomolecular interactions.

Humans Female Cell Line, Tumor Ovarian Neoplasms / drug therapy Spectrum Analysis DNA / chemistry Ruthenium / chemistry Antineoplastic Agents / chemistry Coordination Complexes / chemistry
Cytotoxic DNA-binding Glutathione coordination Metallodrug Ruthenium

Journal

Journal of inorganic biochemistry
ISSN: 1873-3344
Titre abrégé: J Inorg Biochem
Pays: United States
ID NLM: 7905788

Informations de publication

Date de publication:
05 2023
Historique:
received: 11 11 2022
revised: 01 02 2023
accepted: 01 02 2023
pubmed: 22 2 2023
medline: 22 3 2023
entrez: 21 2 2023
Statut: ppublish

Résumé

Iron(II) and Ru(II) half-sandwich compounds encompass some promising pre-clinical anticancer agents whose efficacy may be tuned by structural modification of the coordinated ligands. Here, we combine two such bioactive metal centres in cationic bis(diphenylphosphino)alkane-bridged heterodinuclear [Fe

Identifiants

DOI: 10.1016/j.jinorgbio.2023.112156 PMID: 36801621
pubmed: 36801621
pii: S0162-0134(23)00038-7
doi: 10.1016/j.jinorgbio.2023.112156
pii:
doi:

Substances chimiques

4-cymene 1G1C8T1N7Q
DNA 9007-49-2
Ruthenium 7UI0TKC3U5
Antineoplastic Agents 0
Coordination Complexes 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

112156

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Matylda Odachowski (M)

Maastricht Science Programme, Faculty of Science and Engineering, Maastricht University, Paul Henri Spaaklaan 1, 6229 EN Maastricht, The Netherlands.

Robin Neven (R)

Maastricht Science Programme, Faculty of Science and Engineering, Maastricht University, Paul Henri Spaaklaan 1, 6229 EN Maastricht, The Netherlands.

Giuditta Perversi (G)

Maastricht Science Programme, Faculty of Science and Engineering, Maastricht University, Paul Henri Spaaklaan 1, 6229 EN Maastricht, The Netherlands.

Dario Romano (D)

King Abdullah University of Science and Technology, Department of Chemical Sciences, Division of Physical Sciences and Engineering, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia.

Cathryn A Slabber (CA)

Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, PO WITS 2050 Johannesburg, South Africa.

Mouna Hadiji (M)

Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH1015 Lausanne, Switzerland.

Maarten Honing (M)

Maastricht Multimodal Molecular Imaging (M4i) Institute, Division of Imaging Mass Spectrometry Maastricht University, Universiteitssingel 50, 6229ER Maastricht, The Netherlands.

Yuandi Zhao (Y)

Maastricht Multimodal Molecular Imaging (M4i) Institute, Division of Imaging Mass Spectrometry Maastricht University, Universiteitssingel 50, 6229ER Maastricht, The Netherlands.

Orde Q Munro (OQ)

Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, PO WITS 2050 Johannesburg, South Africa. Electronic address: orde.munro@wits.ac.za.

Burgert Blom (B)

Maastricht Science Programme, Faculty of Science and Engineering, Maastricht University, Paul Henri Spaaklaan 1, 6229 EN Maastricht, The Netherlands. Electronic address: burgert.blom@maastrichtuniversity.nl.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Ionic mononuclear [Fe] and heterodinuclear...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Ionic mononuclear [Fe] and heterodinuclear...
questionsmedicales.fr › Maladies endocriniennes › Troubles gonadiques › Maladies ovariennes › Tumeurs de l'ovaire › Ionic mononuclear [Fe] and heterodinuclear...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Ionic mononuclear [Fe] and heterodinuclear...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › Ionic mononuclear [Fe] and heterodinuclear...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Ruthénium › Ionic mononuclear [Fe] and heterodinuclear...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Ionic mononuclear [Fe] and heterodinuclear...
questionsmedicales.fr › Composés chimiques organiques › Complexes de coordination › Ionic mononuclear [Fe] and heterodinuclear...