Neurological soft signs are increased in major depressive disorder irrespective of treatment.
Antidepressant treatment
Electroconvulsive therapy
Major depressive disorder
Neurological soft signs
Journal
Journal of neural transmission (Vienna, Austria : 1996)
ISSN: 1435-1463
Titre abrégé: J Neural Transm (Vienna)
Pays: Austria
ID NLM: 9702341
Informations de publication
Date de publication:
04 2023
04 2023
Historique:
received:
23
11
2022
accepted:
11
02
2023
medline:
30
3
2023
pubmed:
22
2
2023
entrez:
21
2
2023
Statut:
ppublish
Résumé
The significance of neurological soft signs (NSS) in major depressive disorder (MDD) remains unclear and the stability of NSS in relation to antidepressant treatment has never been investigated. We hypothesized that NSS are relatively stable trait markers of MDD. We thus predicted that patients show more NSS than healthy controls, irrespective of illness duration and antidepressant treatment. To test this hypothesis, NSS were assessed in chronically depressed, medicated MDD patients before (n = 23) and after (n = 18) a series of electroconvulsive therapy (ECT). In addition, NSS were assessed once in acutely depressed, unmedicated MDD patients (n = 16) and healthy controls (n = 20). We found that both chronically depressed, medicated MDD patients and acutely depressed, unmedicated MDD patients showed more NSS than healthy controls. The degree of NSS in both patient groups did not differ. Importantly, we found no change in NSS after on average eleven sessions of ECT. Thus, the manifestation of NSS in MDD seems to be independent of illness duration and pharmacological and electroconvulsive antidepressant treatment. From a clinical perspective, our findings corroborate the neurological safety of ECT.
Identifiants
pubmed: 36801977
doi: 10.1007/s00702-023-02602-z
pii: 10.1007/s00702-023-02602-z
pmc: PMC10050027
doi:
Substances chimiques
Antidepressive Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
575-583Informations de copyright
© 2023. The Author(s).
Références
Am J Psychiatry. 1995 Feb;152(2):191-6
pubmed: 7840351
Acta Psychiatr Scand. 1988 Oct;78(4):505-9
pubmed: 3227971
Schizophr Res. 2000 Jun 16;43(2-3):109-16
pubmed: 10858629
Lancet. 2003 Mar 8;361(9360):799-808
pubmed: 12642045
Biol Psychiatry. 1984 May;19(5):703-19
pubmed: 6145453
Biol Psychiatry. 2010 Sep 15;68(6):568-77
pubmed: 20673880
Psychiatry Res. 2018 Mar;261:253-258
pubmed: 29329044
Prog Neuropsychopharmacol Biol Psychiatry. 2011 Jun 1;35(4):1074-9
pubmed: 21396423
Acta Psychiatr Scand. 2003 Aug;108(2):144-6
pubmed: 12823171
Biol Psychiatry Glob Open Sci. 2022 Jan;2(1):61-69
pubmed: 35419552
Psychol Med. 2022 Jun;52(8):1401-1410
pubmed: 35100527
Neurology. 2001 Aug 14;57(3):553-5
pubmed: 11502937
Schizophr Bull. 2021 Jan 23;47(1):118-127
pubmed: 32656567
Br J Psychiatry. 2006 Apr;188:366-73
pubmed: 16582064
Eur Psychiatry. 2012 Apr;27(3):192-9
pubmed: 20538431
Front Psychiatry. 2014 Dec 23;5:185
pubmed: 25566104
J Neuropsychiatry Clin Neurosci. 1993 Spring;5(2):183-8
pubmed: 8508036
Indian J Psychiatry. 1989 Jul;31(3):224-9
pubmed: 21927389
Am J Psychiatry. 2000 Apr;157(4):560-5
pubmed: 10739414
Am J Psychiatry. 1988 Jan;145(1):11-8
pubmed: 3276226
Schizophr Bull. 2005 Oct;31(4):962-77
pubmed: 15958818
Schizophr Bull. 2010 Nov;36(6):1089-104
pubmed: 19377058
Acta Psychiatr Scand. 2011 Jun;123(6):451-8
pubmed: 21219267
PeerJ. 2019 Nov 29;7:e8170
pubmed: 31803543
J Neuropsychiatry Clin Neurosci. 2005 Fall;17(4):472-7
pubmed: 16387985
J Neurol Neurosurg Psychiatry. 1996 Mar;60(3):326-32
pubmed: 8609512
Psychol Med. 2009 Mar;39(3):371-9
pubmed: 18578894
Biol Psychiatry. 2019 Mar 15;85(6):443-453
pubmed: 30470559
Biol Psychiatry. 2006 Feb 15;59(4):341-8
pubmed: 16169527
Front Psychiatry. 2020 Oct 20;11:533662
pubmed: 33192652
Front Psychiatry. 2018 Jan 08;8:272
pubmed: 29375401
J Clin Psychiatry. 2006 Apr;67(4):541-6
pubmed: 16669718
Br J Psychiatry Suppl. 2002 Sep;43:s50-7
pubmed: 12271801
Eur Arch Psychiatry Clin Neurosci. 2021 Dec;271(8):1465-1473
pubmed: 32417958
Psychiatry Res. 1989 Mar;27(3):335-50
pubmed: 2710870
Eur Neuropsychopharmacol. 2018 Nov;28(11):1185-1193
pubmed: 30170709
Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jun 3;43:72-8
pubmed: 23266480
World J Psychiatry. 2015 Jun 22;5(2):182-92
pubmed: 26110120
Schizophr Res. 1991 Dec;6(1):25-30
pubmed: 1786233
Br J Psychiatry. 2005 Apr;186:308-13
pubmed: 15802687
Arch Gen Psychiatry. 2006 May;63(5):571-6
pubmed: 16651514
J Nerv Ment Dis. 1979 Mar;167(3):161-5
pubmed: 438784
Arch Gen Psychiatry. 1985 Apr;42(4):342-51
pubmed: 3977551
Schizophr Res. 2012 Jan;134(1):27-32
pubmed: 22018942
Am J Psychiatry. 1997 Jan;154(1):4-17
pubmed: 8988952
Arch Gen Psychiatry. 2000 Feb;57(2):181-6
pubmed: 10665621
Acta Psychiatr Scand. 2004 Jul;110(1):29-35
pubmed: 15180777