The adjunctive effect of a resorbable membrane to a xenogeneic bone replacement graft in the reconstructive surgical therapy of peri-implantitis: A randomized clinical trial.
barrier membrane
bone regeneration
clinical trial
peri-implant defect
peri-implantitis
reconstructive therapy
Journal
Journal of clinical periodontology
ISSN: 1600-051X
Titre abrégé: J Clin Periodontol
Pays: United States
ID NLM: 0425123
Informations de publication
Date de publication:
06 2023
06 2023
Historique:
revised:
17
01
2023
received:
14
11
2022
accepted:
14
02
2023
medline:
16
5
2023
pubmed:
22
2
2023
entrez:
21
2
2023
Statut:
ppublish
Résumé
To evaluate the potential adjunctive effect of a resorbable collagen membrane covering a xenogeneic bone replacement graft in the reconstructive surgical therapy of peri-implantitis. Forty-three patients (43 implants) diagnosed with peri-implantitis associated with intra-bony defects were treated with a surgical reconstructive approach that included a xenogeneic bone substitute material. Additionally, resorbable collagen membranes were placed over the grafting material at sites randomly allocated to the test group; conversely, no membranes were placed in the control group. Clinical outcomes, namely probing pocket depth (PPD), bleeding and suppuration on probing (BoP and SoP), marginal mucosal level (REC) and keratinized mucosa width (KMW), were recorded at baseline and 6 and 12 months after surgery. Radiographic marginal bone levels (MBLs) and patient-reported outcomes (PROs) were assessed at baseline and 12 months. A composite outcome (success) was evaluated at 12 months, which included the absence of BoP/SoP, PPD ≤5 mm and reduction of buccal marginal mucosal level (buccal REC) of ≤1 mm. At 12 months, no implants were lost and treatment success was observed at 36.8% and 45.0% of implants in the test and control groups, respectively (p = .61). Similarly, there were no significant differences between groups in terms of changes of PPD, BoP/SoP, KMW, MBL or buccal REC. Post-surgical complications were observed in the test group only (e.g., soft tissue dehiscence, exposure of particulate bone graft and/or resorbable membrane). Longer surgical times (~10 min; p < .05) and higher levels of self-reported pain at 2 weeks (p < .01) were observed in the test group. This study failed to demonstrate the presence of added clinical or radiographic benefits of the use of a resorbable membrane to cover a bone substitute material within the reconstructive surgical therapy of peri-implantitis associated with intra-bony defects.
Substances chimiques
Bone Substitutes
0
Collagen
9007-34-5
Dental Implants
0
Types de publication
Randomized Controlled Trial
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
765-783Informations de copyright
© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Références
Baima, G., Citterio, F., Romandini, M., Romano, F., Mariani, G., Buduneli, N., & Aimetti, M. (2022). Surface decontamination protocols for surgical treatment of peri-implantitis: A systematic review with meta- analysis. Clinical Oral Implants Research, 33(11), 1069-1086.
Berglundh, J., Romandini, M., Derks, J., Sanz, M., & Berglundh, T. (2021). Clinical findings and history of bone loss at implant sites. Clinical Oral Implants Research, 32(3), 314-323. https://doi.org/10.1111/clr.13701
Carcuac, O., Derks, J., Abrahamsson, I., Wennström, J. L., & Berglundh, T. (2020). Risk for recurrence of disease following surgical therapy of peri-implantitis-a prospective longitudinal study. Clinical Oral Implants Research, 31(11), 1072-1077. https://doi.org/10.1111/clr.13653
Cortellini, P., Tonetti, M. S., Lang, N. P., Suvan, J. E., Zucchelli, G., Vangsted, T., Silvestri, M., Rossi, R., McClain, P., Fonzar, A., Dubravec, D., & Adriaens, P. (2001). The simplified papilla preservation flap in the regenerative treatment of deep Intrabony defects: Clinical outcomes and postoperative morbidity. Journal of Periodontology, 72, 1702-1712. https://doi.org/10.1902/jop.2001.72.12.1702
de Tapia, B., Valles, C., Ribeiro-Amaral, T., et al. (2019). The adjunctive effect of a titanium brush in implant surface decontamination at peri-implantitis surgical regenerative interventions: A randomized controlled clinical trial. Journal of Clinical Periodontology, 46, 586-596. https://doi.org/10.1111/jcpe.13095
Derks, J., Ortiz-Vigón, A., Guerrero, A., Donati, M., Bressan, E., Ghensi, P., Schaller, D., Tomasi, C., Karlsson, K., Abrahamsson, I., Ichioka, Y., Dionigi, C., Regidor, E., & Berglundh, T. (2022). Reconstructive surgical therapy of peri-implantitis: A multicenter randomized controlled clinical trial. Clinical Oral Implants Research, 33, 921-944. https://doi.org/10.1111/clr.13972
Derks, J., Schaller, D., Håkansson, J., Wennström, J. L., Tomasi, C., & Berglundh, T. (2016). Peri-implantitis - Onset and pattern of progression. Journal of Clinical Periodontology, 43, 383-388. https://doi.org/10.1111/jcpe.12535
Derks, J., Ichioka, Y., Dionigi, C., Trullenque-Eriksson, A., Berglundh, J., Tomasi, C., & Graziani, F. (2022). Prevention and management of peri-implant mucositis and peri-implantitis: A systematic review of outcome measures used in clinical studies in the last 10 years. Journal of Clinical Periodontology, 1-12. https://doi.org/10.1111/jcpe.13608
Galarraga-Vinueza, M. E., Obreja, K., Magini, R., Sculean, A., Sader, R., & Schwarz, F. (2020). Volumetric assessment of tissue changes following combined surgical therapy of peri-implantitis: A pilot study. Journal of Clinical Periodontology, 47, 1159-1168. https://doi.org/10.1111/jcpe.13335
Isehed, C., Holmlund, A., Renvert, S., Svenson, B., Johansson, I., & Lundberg, P. (2016). Effectiveness of enamel matrix derivative on the clinical and microbiological outcomes following surgical regenerative treatment of peri-implantitis. A randomized controlled trial. Journal of Clinical Periodontology, 43(10), 863-873. https://doi.org/10.1111/jcpe.12583
Isehed, C., Svenson, B., Lundberg, P., & Holmlund, A. (2018). Surgical treatment of peri-implantitis using enamel matrix derivative, an RCT: 3- and 5-year follow-up. Journal of Clinical Periodontology, 45, 744-753. https://doi.org/10.1111/jcpe.12894
Jepsen, K., Jepsen, S., Laine, M. L., Anssari Moin, D., Pilloni, A., Zeza, B., & Renvert, S. (2016). Reconstruction of peri-implant osseous defects: A multicenter randomized trial. Journal of Dental Research, 95(1), 58-66. https://doi.org/10.1177/0022034515610056
Karlsson, K., Derks, J., Håkansson, J., Wennström, J. L., Petzold, M., & Berglundh, T. (2019). Interventions for peri-implantitis and their effects on further bone loss: A retrospective analysis of a registry-based cohort. Journal of Clinical Periodontology, 46(8), 872-879. https://doi.org/10.1111/jcpe.13129
Khoury, F., & Buchmann, R. (2001). Surgical therapy of peri-implant disease: A 3-year follow-up study of cases treated with 3 different techniques of bone regeneration. Journal of Periodontology, 72(11), 1498-1508. https://doi.org/10.1902/jop.2001.72.11.1498
La Monaca, G., Pranno, N., Annibali, S., Cristalli, M. P., & Polimeni, A. (2018). Clinical and radiographic outcomes of a surgical reconstructive approach in the treatment of peri-implantitis lesions: A 5-year prospective case series. Clinical Oral Implants Research, 00, 1-13. https://doi.org/10.1111/clr.13369
Monje, A., Pons, R., Insua, A., Nart, J., Wang, H.-L., & Schwarz, F. (2019). Morphology and severity of peri-implantitis bone defects. Clinical Implant Dentistry and Related Research, 21, 635-643. https://doi.org/10.1111/cid.12791
Monje, A., Pons, R., Roccuzzo, A., Salvi, G. E., & Nart, J. (2020). Reconstructive therapy for the management of peri-implantitis via submerged guided bone regeneration: A prospective case series. Clinical Implant Dentistry and Related Research, 22, 1-9. https://doi.org/10.1111/cid.12913
Monje, A., Pons, R., Vilarrasa, J., Nart, J., & Wang, H.-L. (2022). Significance of barrier membrane on the reconstructive therapy of peri-implantitis: A randomized controlled trial. Journal of Periodontology, 1-13. https://doi.org/10.1002/JPER.22-0511
Renvert, S., Giovannoli, J.-L., RoosJansåker, A.-M., & Rinke, S. (2021). Surgical treatment of peri-implantitis with or without a deproteinized bovine bone mineral and a native bilayer collagen membrane: A randomized clinical trial. Journal of Clinical Periodontology, 48, 1-10. https://doi.org/10.1111/jcpe.13513
Renvert, S., Roos-Jansåker, A.-M., & Persson, G. R. (2018). Surgical treatment of peri-implantitis lesions with or without the use of a bone substitute-A randomized clinical trial. Journal of Clinical Periodontology, 45, 1266-1274. https://doi.org/10.1111/jcpe.129
Rodrigo, D., Sanz-Sanchez, I., Figuero, E., Llodra, J. C., Bravo, M., Caffesse, R. G., Vallcorba, N., Guerrero, A., & Herrera, D. (2018). Prevalence and risk indicators of peri-implant diseases in Spain. Journal of Clinical Periodontology, 45(12), 1510-1520. https://doi.org/10.1111/jcpe.13017
Romandini, M., Berglundh, J., Derks, J., Sanz, M., & Berglundh, T. (2021). Diagnosis of peri- implantitis in the absence of baseline data: A diagnostic accuracy study. Clinical Oral Implants Research, 32, 297-313. https://doi.org/10.1111/clr.13700
Romandini, M., Cordaro, M., Donno, S., & Cordaro, L. (2019). Discrepancy between patient satisfaction and biologic complication rate in patients rehabilitated with overdentures and not participating in a structured maintenance program after 7 to 12 years of loading. The International Journal of Oral & Maxillofacial Implants, 34(5), 1143-1151. https://doi.org/10.11607/jomi.7465
Romandini, M., Laforí, A., Pedrinaci, I., Baima, G., Ferrarotti, F., Lima, C., Paternó Holtzman, L., Aimetti, M., Cordaro, L., & Sanz, M. (2022). Effect of sub-marginal instrumentation before surgical treatment of peri-implantitis: A multi-Centre randomized clinical trial. Journal of Clinical Periodontology, Online ahead of print, 49, 1334-1345. https://doi.org/10.1111/jcpe.13713
Romandini, M., Lima, C., Pedrinaci, I., Araoz, A., Costanza Soldini, M., & Sanz, M. (2021). Prevalence and risk/protective indicators of peri-implant diseases: A university-representative cross-sectional study. Clinical Oral Implants Research, 32(1), 112-122. https://doi.org/10.1111/clr.13684
Romandini, M., Lima, C., Pedrinaci, I., Araoz, A., Soldini, C., & Sanz, M. (2021). Clinical signs, symptoms, perceptions, and impact on quality of life in patients suffering from peri-implant diseases: A university-representative cross- sectional study. Clinical Oral Implants Research, 32(1), 100-111. https://doi.org/10.1111/clr.13683
Romandini, M., Pedrinaci, I., Lima, C., Soldini, M. C., Araoz, A., & Sanz, M. (2021). Prevalence and risk/protective indicators of buccal soft tissue dehiscence around dental implants. Journal of Clinical Periodontology, 95(9), 995-999. https://doi.org/10.1111/jcpe.13417
Roos-Jansåker, A. M., Lindahl, C., Persson, G. R., & Renvert, S. (2011). Long-term stability of surgical bone regenerative procedures of peri-implantitis lesions in a prospective case-control study over 3 years. Journal of Clinical Periodontology, 38(6), 590-597. https://doi.org/10.1111/j.1600-051X.2011.01729.x
Roos-Jansåker, A. M., Persson, G. R., Lindahl, C., & Renvert, S. (2014). Surgical treatment of peri-implantitis using a bone substitute with or without a resorbable membrane: A 5-year follow-up. Journal of Clinical Periodontology, 41(11), 1108-1114. https://doi.org/10.1111/jcpe.12308
Roos-Jansåker, A. M., Renvert, H., Lindahl, C., & Renvert, S. (2007). Surgical treatment of peri-implantitis using a bone substitute with or without a resorbable membrane: A prospective cohort study. Journal of Clinical Periodontology, 34, 625-632. https://doi.org/10.1111/j.1600-051X.2007.01102.x
Sanz-Sánchez, I., Ortiz-Vigón, A., Sanz-Martín, I., Figuero, E., & Sanz, M. (2015). Effectiveness of lateral bone augmentation on the alveolar crest dimension: A systematic review and meta-analysis. Journal of Dental Research, 94(9 Suppl), 128 S-42 S. https://doi.org/10.1177/0022034515594780
Schulz, K. F., Altman, D. G., Moher, D., & CONSORT Group. (2010). CONSORT 2010 statement: Updated guidelines for reporting parallel group randomized trials. Trials, 11, 32.
Tomasi, C., & Derks, J. (2012). Clinical research of peri-implant diseases-quality of reporting, case definitions and methods to study incidence, prevalence and risk factors of peri-implant diseases. Journal of Clinical Periodontology, 39(Suppl 12), 207-223. https://doi.org/10.1111/j.1600-051X.2011.01831.x
Tomasi, C., Regidor, E., Ortiz-Vigón, A., & Derks, J. (2019). Efficacy of reconstructive surgical therapy at peri-implantitis-related bone defects. A systematic review and meta-analysis. Journal of Clinical Periodontology, 46, 340-356. https://doi.org/10.1111/jcpe.13070
Verket, A., Koldsland, O. C., Bunaes, D., Lie, S. A., & Romandini, M. (2023). Non-surgical therapy of peri-implant mucositis - Mechanical/physical approaches: A systematic review. Journal of Clinical Periodontology, 1-11. https://doi.org/10.1111/jcpe.13789
Vignoletti, F., Di Domenico, G. L., Di Martino, M., Montero, E., & de Sanctis, M. (2019). Prevalence and risk indicators of peri- implantitis in a sample of university-based dental patients in Italy: A cross-sectional study. Journal of Clinical Periodontology, 46(5), 597-605. https://doi.org/10.1111/jcpe.13111
Wohlfahrt, J. C., Lyngstadaas, S. P., Ronold, H. J., Saxegaard, E., Ellingsen, J. E., Karlsson, S., & Aass, A. M. (2012). Porous titanium granules in the surgical treatment of peri-implant osseous defects: A randomized clinical trial. International Journal of Oral and Maxillofacial Implants, 27(2), 401-410.